A Multifactorial Weight Reduction Programme for Children with Overweight and Asthma: A Randomized Controlled Trial

Maartje Willeboordse, Kim van de Kant, Frans E S Tan, Sandra Mulkens, Julia Schellings, Yvonne Crijns, Liesbeth van der Ploeg, Constant P van Schayck, Edward Dompeling

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
112 Downloads (Pure)

Abstract

BACKGROUND: There is increasing evidence that obesity is related to asthma development and severity. However, it is largely unknown whether weight reduction can influence asthma management, especially in children.

OBJECTIVE: To determine the effects of a multifactorial weight reduction intervention on asthma management in overweight/obese children with (a high risk of developing) asthma.

METHODS: An 18-month weight-reduction randomized controlled trial was conducted in 87 children with overweight/obesity and asthma. Every six months, measurements of anthropometry, lung function, lifestyle parameters and inflammatory markers were assessed. Analyses were performed with linear mixed models for longitudinal analyses.

RESULTS: After 18 months, the body mass index-standard deviation score decreased by -0.14±0.29 points (p<0.01) in the intervention group and -0.12±0.34 points (p<0.01) in the control group. This change over time did not differ between groups (p>0.05). Asthma features (including asthma control and asthma-related quality of life) and lung function indices (static and dynamic) improved significantly over time in both groups. The FVC% predicted improved over time by 10.1 ± 8.7% in the intervention group (p<0.001), which was significantly greater than the 6.1 ± 8.4% in the control group (p<0.05).

CONCLUSIONS & CLINICAL RELEVANCE: Clinically relevant improvements in body weight, lung function and asthma features were found in both the intervention and control group, although some effects were more pronounced in the intervention group (FVC, asthma control, and quality of life). This implies that a weight reduction intervention could be clinically beneficial for children with asthma.

TRIAL REGISTRATION: ClinicalTrials.gov NCT00998413.

Original languageEnglish
Article numbere0157158
Number of pages14
JournalPLOS ONE
Volume11
Issue number6
DOIs
Publication statusPublished - 13 Jun 2016

Keywords

  • QUALITY-OF-LIFE
  • CHILDHOOD OVERWEIGHT
  • INCIDENT ASTHMA
  • DUTCH CHILDREN
  • OBESE CHILDREN
  • LUNG-FUNCTION
  • RISK
  • INTERVENTION
  • METAANALYSIS
  • ADOLESCENTS

Cite this

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title = "A Multifactorial Weight Reduction Programme for Children with Overweight and Asthma: A Randomized Controlled Trial",
abstract = "BACKGROUND: There is increasing evidence that obesity is related to asthma development and severity. However, it is largely unknown whether weight reduction can influence asthma management, especially in children.OBJECTIVE: To determine the effects of a multifactorial weight reduction intervention on asthma management in overweight/obese children with (a high risk of developing) asthma.METHODS: An 18-month weight-reduction randomized controlled trial was conducted in 87 children with overweight/obesity and asthma. Every six months, measurements of anthropometry, lung function, lifestyle parameters and inflammatory markers were assessed. Analyses were performed with linear mixed models for longitudinal analyses.RESULTS: After 18 months, the body mass index-standard deviation score decreased by -0.14±0.29 points (p<0.01) in the intervention group and -0.12±0.34 points (p<0.01) in the control group. This change over time did not differ between groups (p>0.05). Asthma features (including asthma control and asthma-related quality of life) and lung function indices (static and dynamic) improved significantly over time in both groups. The FVC{\%} predicted improved over time by 10.1 ± 8.7{\%} in the intervention group (p<0.001), which was significantly greater than the 6.1 ± 8.4{\%} in the control group (p<0.05).CONCLUSIONS & CLINICAL RELEVANCE: Clinically relevant improvements in body weight, lung function and asthma features were found in both the intervention and control group, although some effects were more pronounced in the intervention group (FVC, asthma control, and quality of life). This implies that a weight reduction intervention could be clinically beneficial for children with asthma.TRIAL REGISTRATION: ClinicalTrials.gov NCT00998413.",
keywords = "QUALITY-OF-LIFE, CHILDHOOD OVERWEIGHT, INCIDENT ASTHMA, DUTCH CHILDREN, OBESE CHILDREN, LUNG-FUNCTION, RISK, INTERVENTION, METAANALYSIS, ADOLESCENTS",
author = "Maartje Willeboordse and {van de Kant}, Kim and Tan, {Frans E S} and Sandra Mulkens and Julia Schellings and Yvonne Crijns and Ploeg, {Liesbeth van der} and {van Schayck}, {Constant P} and Edward Dompeling",
year = "2016",
month = "6",
day = "13",
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A Multifactorial Weight Reduction Programme for Children with Overweight and Asthma : A Randomized Controlled Trial. / Willeboordse, Maartje; van de Kant, Kim; Tan, Frans E S; Mulkens, Sandra; Schellings, Julia; Crijns, Yvonne; Ploeg, Liesbeth van der; van Schayck, Constant P; Dompeling, Edward.

In: PLOS ONE, Vol. 11, No. 6, e0157158, 13.06.2016.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - A Multifactorial Weight Reduction Programme for Children with Overweight and Asthma

T2 - A Randomized Controlled Trial

AU - Willeboordse, Maartje

AU - van de Kant, Kim

AU - Tan, Frans E S

AU - Mulkens, Sandra

AU - Schellings, Julia

AU - Crijns, Yvonne

AU - Ploeg, Liesbeth van der

AU - van Schayck, Constant P

AU - Dompeling, Edward

PY - 2016/6/13

Y1 - 2016/6/13

N2 - BACKGROUND: There is increasing evidence that obesity is related to asthma development and severity. However, it is largely unknown whether weight reduction can influence asthma management, especially in children.OBJECTIVE: To determine the effects of a multifactorial weight reduction intervention on asthma management in overweight/obese children with (a high risk of developing) asthma.METHODS: An 18-month weight-reduction randomized controlled trial was conducted in 87 children with overweight/obesity and asthma. Every six months, measurements of anthropometry, lung function, lifestyle parameters and inflammatory markers were assessed. Analyses were performed with linear mixed models for longitudinal analyses.RESULTS: After 18 months, the body mass index-standard deviation score decreased by -0.14±0.29 points (p<0.01) in the intervention group and -0.12±0.34 points (p<0.01) in the control group. This change over time did not differ between groups (p>0.05). Asthma features (including asthma control and asthma-related quality of life) and lung function indices (static and dynamic) improved significantly over time in both groups. The FVC% predicted improved over time by 10.1 ± 8.7% in the intervention group (p<0.001), which was significantly greater than the 6.1 ± 8.4% in the control group (p<0.05).CONCLUSIONS & CLINICAL RELEVANCE: Clinically relevant improvements in body weight, lung function and asthma features were found in both the intervention and control group, although some effects were more pronounced in the intervention group (FVC, asthma control, and quality of life). This implies that a weight reduction intervention could be clinically beneficial for children with asthma.TRIAL REGISTRATION: ClinicalTrials.gov NCT00998413.

AB - BACKGROUND: There is increasing evidence that obesity is related to asthma development and severity. However, it is largely unknown whether weight reduction can influence asthma management, especially in children.OBJECTIVE: To determine the effects of a multifactorial weight reduction intervention on asthma management in overweight/obese children with (a high risk of developing) asthma.METHODS: An 18-month weight-reduction randomized controlled trial was conducted in 87 children with overweight/obesity and asthma. Every six months, measurements of anthropometry, lung function, lifestyle parameters and inflammatory markers were assessed. Analyses were performed with linear mixed models for longitudinal analyses.RESULTS: After 18 months, the body mass index-standard deviation score decreased by -0.14±0.29 points (p<0.01) in the intervention group and -0.12±0.34 points (p<0.01) in the control group. This change over time did not differ between groups (p>0.05). Asthma features (including asthma control and asthma-related quality of life) and lung function indices (static and dynamic) improved significantly over time in both groups. The FVC% predicted improved over time by 10.1 ± 8.7% in the intervention group (p<0.001), which was significantly greater than the 6.1 ± 8.4% in the control group (p<0.05).CONCLUSIONS & CLINICAL RELEVANCE: Clinically relevant improvements in body weight, lung function and asthma features were found in both the intervention and control group, although some effects were more pronounced in the intervention group (FVC, asthma control, and quality of life). This implies that a weight reduction intervention could be clinically beneficial for children with asthma.TRIAL REGISTRATION: ClinicalTrials.gov NCT00998413.

KW - QUALITY-OF-LIFE

KW - CHILDHOOD OVERWEIGHT

KW - INCIDENT ASTHMA

KW - DUTCH CHILDREN

KW - OBESE CHILDREN

KW - LUNG-FUNCTION

KW - RISK

KW - INTERVENTION

KW - METAANALYSIS

KW - ADOLESCENTS

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DO - 10.1371/journal.pone.0157158

M3 - Article

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VL - 11

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 6

M1 - e0157158

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