A multi-omics approach to investigate the inflammatory response to life course socioeconomic position

Raphaele Castagne; Michelle Kelly-Irving; Vittorio Krogh; Domenico Palli; Salvatore Panico; Carlotta Sacerdote; Rosario Tumino; Dennie G. A. J. Hebels; Jos C. S. Kleinjans; Theo M. C. M. de Kok; Panagiotis Georgiadis; Soterios A. Kyrtopoulos; Roel Vermeulen; Silvia Stringhini; Paolo Vineis; Marc Chadeau-Hyam; Cyrille Delpierre

doi:10.2217/epi-2019-0261

A multi-omics approach to investigate the inflammatory response to life course socioeconomic position

Raphaele Castagne^*
, Michelle Kelly-Irving
, Vittorio Krogh
, Domenico Palli
, Salvatore Panico
, Carlotta Sacerdote
, Rosario Tumino
, Dennie G. A. J. Hebels
, Jos C. S. Kleinjans
, Theo M. C. M. de Kok
, Panagiotis Georgiadis
, Soterios A. Kyrtopoulos
, Roel Vermeulen
, Silvia Stringhini
, Paolo Vineis
, Marc Chadeau-Hyam
, Cyrille Delpierre

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Aim:Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded.Materials & methods:We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants.Results & conclusion:We identified 61 potentialcisacting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.

Original language	English
Pages (from-to)	1287-1302
Number of pages	16
Journal	Epigenomics
Volume	12
Issue number	15
DOIs	https://doi.org/10.2217/epi-2019-0261
Publication status	Published - Jul 2020

Keywords

DNA methylation
gene expression
inflammation
life course epidemiology
protein
socioeconomic position
CHRONIC LYMPHOCYTIC-LEUKEMIA
DNA METHYLATION
GENE-EXPRESSION
RISK-FACTORS
SOCIAL DETERMINANTS
BLOOD-SAMPLES
HEALTH
STRESS
CHILDHOOD
CELLS

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Castagne, R., Kelly-Irving, M., Krogh, V., Palli, D., Panico, S., Sacerdote, C., Tumino, R., Hebels, D. G. A. J., Kleinjans, J. C. S., de Kok, T. M. C. M., Georgiadis, P., Kyrtopoulos, S. A., Vermeulen, R., Stringhini, S., Vineis, P., Chadeau-Hyam, M., & Delpierre, C. (2020). A multi-omics approach to investigate the inflammatory response to life course socioeconomic position. Epigenomics, 12(15), 1287-1302. https://doi.org/10.2217/epi-2019-0261

@article{6fa355bbb75f4badb1f22799a6c49235,

title = "A multi-omics approach to investigate the inflammatory response to life course socioeconomic position",

abstract = "Aim:Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded.Materials \& methods:We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants.Results \& conclusion:We identified 61 potentialcisacting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.",

keywords = "DNA methylation, gene expression, inflammation, life course epidemiology, protein, socioeconomic position, CHRONIC LYMPHOCYTIC-LEUKEMIA, DNA METHYLATION, GENE-EXPRESSION, RISK-FACTORS, SOCIAL DETERMINANTS, BLOOD-SAMPLES, HEALTH, STRESS, CHILDHOOD, CELLS",

author = "Raphaele Castagne and Michelle Kelly-Irving and Vittorio Krogh and Domenico Palli and Salvatore Panico and Carlotta Sacerdote and Rosario Tumino and Hebels, \{Dennie G. A. J.\} and Kleinjans, \{Jos C. S.\} and \{de Kok\}, \{Theo M. C. M.\} and Panagiotis Georgiadis and Kyrtopoulos, \{Soterios A.\} and Roel Vermeulen and Silvia Stringhini and Paolo Vineis and Marc Chadeau-Hyam and Cyrille Delpierre",

note = "Funding Information: This work was supported by the Institut National du Cancer (SHSESP14–082 to R Castagn{\'e}). This study was supported by the European Commission Horizon 2020 grant number 633666 to P Vineis and the 7th European Framework Programme (FP7) for the Envirogenomarkers (226756 to SA Kyrtopoulos) projects. The Centre for Environment and Health is supported by the Medical Research Council and Public Health England (MR/L01341X/1). M Chadeau-Hyam acknowledges support from Cancer Research UK, Population Research Committee Project grant ({\textquoteleft}Mechanomics{\textquoteright} project \#22184 to M Chadeau-Hyam). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2020 Future Medicine Ltd.. All rights reserved.",

year = "2020",

month = jul,

doi = "10.2217/epi-2019-0261",

language = "English",

volume = "12",

pages = "1287--1302",

journal = "Epigenomics",

issn = "1750-1911",

publisher = "Routledge/Taylor \& Francis Group",

number = "15",

}

Castagne, R, Kelly-Irving, M, Krogh, V, Palli, D, Panico, S, Sacerdote, C, Tumino, R, Hebels, DGAJ, Kleinjans, JCS, de Kok, TMCM, Georgiadis, P, Kyrtopoulos, SA, Vermeulen, R, Stringhini, S, Vineis, P, Chadeau-Hyam, M & Delpierre, C 2020, 'A multi-omics approach to investigate the inflammatory response to life course socioeconomic position', Epigenomics, vol. 12, no. 15, pp. 1287-1302. https://doi.org/10.2217/epi-2019-0261

TY - JOUR

T1 - A multi-omics approach to investigate the inflammatory response to life course socioeconomic position

AU - Castagne, Raphaele

AU - Kelly-Irving, Michelle

AU - Krogh, Vittorio

AU - Palli, Domenico

AU - Panico, Salvatore

AU - Sacerdote, Carlotta

AU - Tumino, Rosario

AU - Hebels, Dennie G. A. J.

AU - Kleinjans, Jos C. S.

AU - de Kok, Theo M. C. M.

AU - Georgiadis, Panagiotis

AU - Kyrtopoulos, Soterios A.

AU - Vermeulen, Roel

AU - Stringhini, Silvia

AU - Vineis, Paolo

AU - Chadeau-Hyam, Marc

AU - Delpierre, Cyrille

N1 - Funding Information: This work was supported by the Institut National du Cancer (SHSESP14–082 to R Castagné). This study was supported by the European Commission Horizon 2020 grant number 633666 to P Vineis and the 7th European Framework Programme (FP7) for the Envirogenomarkers (226756 to SA Kyrtopoulos) projects. The Centre for Environment and Health is supported by the Medical Research Council and Public Health England (MR/L01341X/1). M Chadeau-Hyam acknowledges support from Cancer Research UK, Population Research Committee Project grant (‘Mechanomics’ project #22184 to M Chadeau-Hyam). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: © 2020 Future Medicine Ltd.. All rights reserved.

PY - 2020/7

Y1 - 2020/7

N2 - Aim:Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded.Materials & methods:We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants.Results & conclusion:We identified 61 potentialcisacting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.

AB - Aim:Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded.Materials & methods:We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants.Results & conclusion:We identified 61 potentialcisacting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.

KW - DNA methylation

KW - gene expression

KW - inflammation

KW - life course epidemiology

KW - protein

KW - socioeconomic position

KW - CHRONIC LYMPHOCYTIC-LEUKEMIA

KW - DNA METHYLATION

KW - GENE-EXPRESSION

KW - RISK-FACTORS

KW - SOCIAL DETERMINANTS

KW - BLOOD-SAMPLES

KW - HEALTH

KW - STRESS

KW - CHILDHOOD

KW - CELLS

U2 - 10.2217/epi-2019-0261

DO - 10.2217/epi-2019-0261

M3 - Article

C2 - 32875816

SN - 1750-1911

VL - 12

SP - 1287

EP - 1302

JO - Epigenomics

JF - Epigenomics

IS - 15

ER -

A multi-omics approach to investigate the inflammatory response to life course socioeconomic position

Abstract

Keywords

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