@article{6fa355bbb75f4badb1f22799a6c49235,
title = "A multi-omics approach to investigate the inflammatory response to life course socioeconomic position",
abstract = "Aim:Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded.Materials & methods:We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants.Results & conclusion:We identified 61 potentialcisacting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.",
keywords = "DNA methylation, gene expression, inflammation, life course epidemiology, protein, socioeconomic position, CHRONIC LYMPHOCYTIC-LEUKEMIA, DNA METHYLATION, GENE-EXPRESSION, RISK-FACTORS, SOCIAL DETERMINANTS, BLOOD-SAMPLES, HEALTH, STRESS, CHILDHOOD, CELLS",
author = "Raphaele Castagne and Michelle Kelly-Irving and Vittorio Krogh and Domenico Palli and Salvatore Panico and Carlotta Sacerdote and Rosario Tumino and Hebels, {Dennie G. A. J.} and Kleinjans, {Jos C. S.} and {de Kok}, {Theo M. C. M.} and Panagiotis Georgiadis and Kyrtopoulos, {Soterios A.} and Roel Vermeulen and Silvia Stringhini and Paolo Vineis and Marc Chadeau-Hyam and Cyrille Delpierre",
note = "Funding Information: This work was supported by the Institut National du Cancer (SHSESP14–082 to R Castagn{\'e}). This study was supported by the European Commission Horizon 2020 grant number 633666 to P Vineis and the 7th European Framework Programme (FP7) for the Envirogenomarkers (226756 to SA Kyrtopoulos) projects. The Centre for Environment and Health is supported by the Medical Research Council and Public Health England (MR/L01341X/1). M Chadeau-Hyam acknowledges support from Cancer Research UK, Population Research Committee Project grant ({\textquoteleft}Mechanomics{\textquoteright} project #22184 to M Chadeau-Hyam). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2020 Future Medicine Ltd.. All rights reserved.",
year = "2020",
month = jul,
doi = "10.2217/epi-2019-0261",
language = "English",
volume = "12",
pages = "1287--1302",
journal = "Epigenomics",
issn = "1750-1911",
publisher = "Future Medicine Ltd.",
number = "15",
}