A multi-domain shear-stress dependent diffusive model of cell transport-aided dialysis: analysis and simulation

A. Viguerie*, S. Swapnasrita, A. Veneziani, A. Carlier

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Kidney dialysis is the most widespread treatment method for end-stage renal disease, a debilitating health condition common in industrialized societies. While ubiquitous, kidney dialysis suffers from an inability to remove larger toxins, resulting in a gradual buildup of these toxins in dial-ysis patients, ultimately leading to further health complications. To improve dialysis, hollow fibers incorporating a cell-monolayer with cultured kidney cells have been proposed; however, the design of such a fiber is nontrivial. In particular, the effects of fluid wall-shear stress have an important influ-ence on the ability of the cell layer to transport toxins. In the present work, we introduce a model for cell-transport aided dialysis, incorporating the effects of the shear stress. We analyze the model mathe-matically and establish its well-posedness. We then present a series of numerical results, which suggest that a hollow-fiber design with a wavy profile may increase the efficiency of the dialysis treatment. We investigate numerically the shape of the wavy channel to maximize the toxin clearance. These results demonstrate the potential for the use of computational models in the study and advancement of renal therapies.

Original languageEnglish
Pages (from-to)8188-8200
Number of pages13
JournalMathematical Biosciences and Engineering
Volume18
Issue number6
DOIs
Publication statusPublished - 2021

Keywords

  • dialysis
  • wall shear stress
  • computational fluid dynamics
  • renal processes
  • HOLLOW-FIBER MEMBRANES
  • ON-A-CHIP
  • SOLUTE CLEARANCES
  • KIDNEY

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