A model for arterial adaptation combining microstructural collagen remodeling and 3D tissue growth

I. M. Machyshyn, Peter H. M. Bovendeerd*, A. A. F. van de Ven, P. M. J. Rongen, F. N. van de Vosse

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Web of Science)


Long-term adaptation of soft tissues is realized through growth and remodeling (G&R). Mathematical models are powerful tools in testing hypotheses on G&R and supporting the design and interpretation of experiments. Most theoretical G&R studies concentrate on description of either growth or remodeling. Our model combines concepts of remodeling of collagen recruitment stretch and orientation suggested by other authors with a novel model of general 3D growth. We translate a growth-induced volume change into a change in shape due to the interaction of the growing tissue with its environment. Our G&R model is implemented in a finite element package in 3D, but applied to two rotationally symmetric cases, i.e., the adaptation towards the homeostatic state of the human aorta and the development of a fusiform aneurysm. Starting from a guessed non-homeostatic state, the model is able to reproduce a homeostatic state of an artery with realistic parameters. We investigate the sensitivity of this state to settings of initial parameters. In addition, we simulate G&R of a fusiform aneurysm, initiated by a localized degradation of the matrix of the healthy artery. The aneurysm stabilizes in size soon after the degradation stops.
Original languageEnglish
Pages (from-to)671-687
JournalBiomechanics and modeling in mechanobiology
Issue number6
Publication statusPublished - Dec 2010


  • Artery
  • Aneurysm
  • Remodeling
  • Growth
  • Collagen

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