A Minimal Psychological Intervention in Chronically Ill Elderly Patients with Depression: A Randomized Trial

Femke Lamers*, Catharina C. M. Jonkers, Hans Bosma, Gertrudis I. J. M. Kempen, Jaap A. M. J. Meijer, Brenda W. J. H. Penninx, J. Andre Knottnerus, Jacques T. M. van Eijk

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background: Among older persons with chronic somatic diseases, depression often remains unrecognized and untreated in primary care. The Depression in Elderly with Long-Term Afflictions (DELTA) study aimed to evaluate the effectiveness of a nurse-led minimal psychological intervention (MPI) in chronically ill elderly persons with depression. Methods: A randomized controlled trial was conducted, comparing the MPI with usual care in 361 primary care patients. Four nurses had an average of 4 sessions with the intervention patients, each lasting 1 h, over a maximum period of 3 months. Patients were aged 60 years and older, had a minor depression or mild-to-moderate major depression, and either had type II diabetes or chronic obstructive pulmonary disease. Results: Nine months after the intervention, patients receiving the MPI had significantly fewer depressive symptoms; the intervention patients were also more likely than usual-care controls to show a >= 50% reduction in depressive symptoms relative to baseline values. At 9 months, diabetic MPI patients had a better quality of life than diabetic controls. Conclusions: The nurse-led MPI appears to be a feasible and moderately effective method of managing minor-to-moderate depression in chronically ill elderly persons. However, we cannot rule out attention-placebo effects, and the disappointing finding of a recent economic evaluation showing only a 63% chance of the MPI being cost-effective. From a clinical point of view, however, it is of interest to further evaluate adaptations of the MPI, with a stronger emphasis on detection, watchful waiting and mental health problems in general.
Original languageEnglish
Pages (from-to)217-226
JournalPsychotherapy and Psychosomatics
Issue number4
Publication statusPublished - 2010


  • Elderly population
  • Psychological therapy
  • Depressive disorder
  • Nurse
  • Chronic obstructive pulmonary disease
  • Diabetes mellitus
  • Primary care


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