A medical image-based graphical platform-Features, applications and relevance for brachytherapy

Gabriel P. Fonseca, Brigitte Reniers, Guillaume Landry, Shane White, Murillo Bellezzo, Paula C. G. Antunes, Camila P. de Sales, Eduardo Welteman, Helio Yoriyaz, Frank Verhaegen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Web of Science)

Abstract

PURPOSE: Brachytherapy dose calculation is commonly performed using the Task Group-No 43 Report-Updated protocol (TG-43U1) formalism. Recently, a more accurate approach has been proposed that can handle tissue composition, tissue density, body shape, applicator geometry, and dose reporting either in media or water. Some model-based dose calculation algorithms are based on Monte Carlo (MC) simulations. This work presents a software platform capable of processing medical images and treatment plans, and preparing the required input data for MC simulations. METHODS AND MATERIALS: The A Medical Image-based Graphical platfOrm Brachytherapy module (AMIGOBrachy) is a user interface, coupled to the MCNP6 MC code, for absorbed dose calculations. The AMIGOBrachy was first validated in water for a high-dose-rate Ir-192 source. Next, dose distributions were validated in uniform phantoms consisting of different materials. Finally, dose distributions were obtained in patient geometries. Results were compared against a treatment planning system including a linear Boltzmann transport equation (LBTE) solver capable of handling nonwater heterogeneities. RESULTS: The TG-43U1 source parameters are in good agreement with literature with more than 90% of anisotropy values within 1%. No significant dependence on the tissue composition was observed comparing MC results against an LBTE solver. Clinical cases showed differences up to 25%, when comparing MC results against TG-43U1. About 92% of the voxels exhibited dose differences lower than 2% when comparing MC results against an LBTE solver. CONCLUSION: The AMIGOBrachy can improve the accuracy of the TG-43U1 dose calculation by using a more accurate MC dose calculation algorithm. The AMIGOBrachy can be incorporated in clinical practice via a user-friendly graphical interface.
Original languageEnglish
Pages (from-to)632-639
JournalBrachytherapy
Volume13
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • Brachytherapy
  • Monte Carlo
  • Model-based dose calculation algorithms
  • User interface

Cite this