TY - JOUR
T1 - A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia
AU - Ingason, Andres
AU - Giegling, Ina
AU - Cichon, Sven
AU - Hansen, Thomas
AU - Rasmussen, Henrik B.
AU - Nielsen, Jimmi
AU - Juergens, Gesche
AU - Muglia, Pierandrea
AU - Hartmann, Annette M.
AU - Strengman, Eric
AU - Vasilescu, Catalina
AU - Muehleisen, Thomas W.
AU - Djurovic, Srdjan
AU - Melle, Ingrid
AU - Lerer, Bernard
AU - Moeller, Hans-Juergen
AU - Francks, Clyde
AU - Pietilaeinen, Olli P. H.
AU - Lonnqvist, Jouko
AU - Suvisaari, Jaana
AU - Tuulio-Henriksson, Annamari
AU - Walshe, Muriel
AU - Vassos, Evangelos
AU - di Forti, Marta
AU - Murray, Robin M.
AU - Bonetto, Chiara
AU - Tosato, Sarah
AU - Cantor, Rita M.
AU - Rietschel, Marcella
AU - Craddock, Nick
AU - Owen, Michael J.
AU - Peltonen, Leena
AU - Andreassen, Ole A.
AU - Noethen, Markus M.
AU - St Clair, David
AU - Ophoff, Roel A.
AU - O'Donovan, Michael C.
AU - Collier, David A.
AU - Werge, Thomas
AU - Genetic Risk and Outcome of Psychosis (GROUP) Investigators
AU - van Os, Jim
AU - Krabbendam, Lydia
AU - Myin-Germeys, I.
AU - Rujescu, Dan
PY - 2010/4
Y1 - 2010/4
N2 - The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18,920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 x 10(-5)-1.7 x 10(-3), common OR = 1.09-1.11). The region contains two genes, AHI1 and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.
AB - The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18,920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 x 10(-5)-1.7 x 10(-3), common OR = 1.09-1.11). The region contains two genes, AHI1 and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.
U2 - 10.1093/hmg/ddq009
DO - 10.1093/hmg/ddq009
M3 - Article
C2 - 20071346
VL - 19
SP - 1379
EP - 1386
JO - Human Molecular Genetics
JF - Human Molecular Genetics
SN - 0964-6906
IS - 7
ER -