A "kissing lesion": In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis

Pierre Kolber, Amgad Droby, Alard Roebroeck, Rainer Goebel, Vinzenz Fleischer, Sergiu Groppa, Frauke Zipp

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: The role of cortical lesions (CLs) in disease progression and clinical deficits is increasingly recognized in multiple sclerosis (MS); however the origin of CLs in MS still remains unclear.

OBJECTIVE: Here, we report a para-sulcal CL detected two years after diagnosis in a relapsing-remitting MS (RRMS) patient without manifestation of clinical deficit.

METHODS: Ultra-high field (7T) MR imaging using magnetization-prepared 2 rapid acquisition gradient echoes (MP2RAGE) sequence was performed.

RESULTS: A para-sulcal CL was detected which showed hypointense rim and iso- to hyperintense core. This was detected in the proximity of the leptomeninges in the left precentral gyrus extending to the adjacent postcentral gyrus.

CONCLUSION: This finding indicates that inflammatory infiltration into the cortex through the meninges underlies cortical pathology already in the early stage of disease and in mild disease course.

Original languageEnglish
Pages (from-to)1167-1169
Number of pages3
JournalMultiple Sclerosis Journal
Volume23
Issue number8
Early online date1 Apr 2017
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Multiple sclerosis
  • 7T
  • atypical cortical lesions
  • magnetic resonance imaging
  • CORTICAL DEMYELINATION

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