A guide for assessment of myocardial stiffness in health and disease

Jose Carlos Villalobos Lizardi; Jerome Baranger; Minh B. Nguyen; Atef Asnacios; Aimen Malik; Joost Lumens; Luc Mertens; Mark Friedberg; Craig A. Simmons; Mathieu Pernot; Olivier Villemain

doi:10.1038/s44161-021-00007-3

A guide for assessment of myocardial stiffness in health and disease

Jose Carlos Villalobos Lizardi, Jerome Baranger, Minh B. Nguyen, Atef Asnacios, Aimen Malik, Joost Lumens, Luc Mertens, Mark Friedberg, Craig A. Simmons, Mathieu Pernot, Olivier Villemain^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

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Abstract

Myocardial stiffness is an intrinsic property of the myocardium that influences both diastolic and systolic cardiac function. Myocardial stiffness represents the resistance of this tissue to being deformed and depends on intracellular components of the cardiomyocyte, particularly the cytoskeleton, and on extracellular components, such as collagen fibers. Myocardial disease is associated with changes in myocardial stiffness, and its assessment is a key diagnostic marker of acute or chronic pathological myocardial disease with the potential to guide therapeutic decision-making. In this Review, we appraise the different techniques that can be used to estimate myocardial stiffness, evaluate their advantages and disadvantages, and discuss potential clinical applications.

Original language	English
Pages (from-to)	8-22
Journal	Nature cardiovascular research
Volume	1
DOIs	https://doi.org/10.1038/s44161-021-00007-3
Publication status	Published - Jan 2022

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title = "A guide for assessment of myocardial stiffness in health and disease",

abstract = "Myocardial stiffness is an intrinsic property of the myocardium that influences both diastolic and systolic cardiac function. Myocardial stiffness represents the resistance of this tissue to being deformed and depends on intracellular components of the cardiomyocyte, particularly the cytoskeleton, and on extracellular components, such as collagen fibers. Myocardial disease is associated with changes in myocardial stiffness, and its assessment is a key diagnostic marker of acute or chronic pathological myocardial disease with the potential to guide therapeutic decision-making. In this Review, we appraise the different techniques that can be used to estimate myocardial stiffness, evaluate their advantages and disadvantages, and discuss potential clinical applications.",

author = "{Villalobos Lizardi}, {Jose Carlos} and Jerome Baranger and Nguyen, {Minh B.} and Atef Asnacios and Aimen Malik and Joost Lumens and Luc Mertens and Mark Friedberg and Simmons, {Craig A.} and Mathieu Pernot and Olivier Villemain",

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AU - Villalobos Lizardi, Jose Carlos

AU - Baranger, Jerome

AU - Nguyen, Minh B.

AU - Asnacios, Atef

AU - Malik, Aimen

AU - Lumens, Joost

AU - Mertens, Luc

AU - Friedberg, Mark

AU - Simmons, Craig A.

AU - Pernot, Mathieu

AU - Villemain, Olivier

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N2 - Myocardial stiffness is an intrinsic property of the myocardium that influences both diastolic and systolic cardiac function. Myocardial stiffness represents the resistance of this tissue to being deformed and depends on intracellular components of the cardiomyocyte, particularly the cytoskeleton, and on extracellular components, such as collagen fibers. Myocardial disease is associated with changes in myocardial stiffness, and its assessment is a key diagnostic marker of acute or chronic pathological myocardial disease with the potential to guide therapeutic decision-making. In this Review, we appraise the different techniques that can be used to estimate myocardial stiffness, evaluate their advantages and disadvantages, and discuss potential clinical applications.

AB - Myocardial stiffness is an intrinsic property of the myocardium that influences both diastolic and systolic cardiac function. Myocardial stiffness represents the resistance of this tissue to being deformed and depends on intracellular components of the cardiomyocyte, particularly the cytoskeleton, and on extracellular components, such as collagen fibers. Myocardial disease is associated with changes in myocardial stiffness, and its assessment is a key diagnostic marker of acute or chronic pathological myocardial disease with the potential to guide therapeutic decision-making. In this Review, we appraise the different techniques that can be used to estimate myocardial stiffness, evaluate their advantages and disadvantages, and discuss potential clinical applications.

U2 - 10.1038/s44161-021-00007-3

DO - 10.1038/s44161-021-00007-3

M3 - (Systematic) Review article

SN - 2731-0590

VL - 1

SP - 8

EP - 22

JO - Nature cardiovascular research

JF - Nature cardiovascular research

ER -

A guide for assessment of myocardial stiffness in health and disease

Abstract

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