A genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc-Pietrain resource population

G. Liu; D.G. Jennen; E. Tholen; H. Juengst; T. Kleinwachter; M. Holker; D. Tesfaye; G. Un; H.J. Schreinemachers; E. Murani; S. Ponsuksili; J.J. Kim; K. Schellander; K. Wimmers

doi:10.1111/j.1365-2052.2007.01592.x

A genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc-Pietrain resource population

G. Liu, D.G. Jennen, E. Tholen, H. Juengst, T. Kleinwachter, M. Holker, D. Tesfaye, G. Un, H.J. Schreinemachers, E. Murani, S. Ponsuksili, J.J. Kim, K. Schellander, K. Wimmers^*

^*Corresponding author for this work

NUTRIM School of Nutrition and Translational Research in Metabolism

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We performed a genome-wide QTL scan for production traits in a line cross between Duroc and Pietrain breeds of pigs, which included 585 F(2) progeny produced from 31 full-sib families genotyped with 106 informative microsatellites. A linkage map covering all 18 autosomes and spanning 1987 Kosambi cM was constructed. Thirty-five phenotypic traits including body weight, growth, carcass composition and meat quality traits were analysed using least square regression interval mapping. Twenty-four QTL exceeded the genome-wide significance threshold, while 47 QTL reached the suggestive threshold. These QTL were located at 28 genomic regions on 16 autosomal chromosomes and QTL in 11 regions were significant at the genome-wide level. A QTL affecting pH value in loin was detected on SSC1 between marker-interval S0312-S0113 with strong statistical support (P < 3.0 x 10(-14)); this QTL was also associated with meat colour and conductivity. QTL for carcass composition and average daily gain was also found on SSC1, suggesting multiple QTL. Seventeen genomic segments had only a single QTL that reached at least suggestive significance. Forty QTL exhibited additive inheritance whereas 31 QTL showed (over-) dominance effects. Two QTL for trait backfat thickness were detected on SSC2; a significant paternal effect was found for a QTL in the IGF2 region while another QTL in the middle of SSC2 showed Mendelian expression.

Original language	English
Pages (from-to)	241-252
Journal	Animal Genetics
Volume	38
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2052.2007.01592.x
Publication status	Published - 1 Jan 2007

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10.1111/j.1365-2052.2007.01592.x

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Liu, G., Jennen, D. G., Tholen, E., Juengst, H., Kleinwachter, T., Holker, M., Tesfaye, D., Un, G., Schreinemachers, H. J., Murani, E., Ponsuksili, S., Kim, J. J., Schellander, K., & Wimmers, K. (2007). A genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc-Pietrain resource population. Animal Genetics, 38(3), 241-252. https://doi.org/10.1111/j.1365-2052.2007.01592.x

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title = "A genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc-Pietrain resource population",

abstract = "We performed a genome-wide QTL scan for production traits in a line cross between Duroc and Pietrain breeds of pigs, which included 585 F(2) progeny produced from 31 full-sib families genotyped with 106 informative microsatellites. A linkage map covering all 18 autosomes and spanning 1987 Kosambi cM was constructed. Thirty-five phenotypic traits including body weight, growth, carcass composition and meat quality traits were analysed using least square regression interval mapping. Twenty-four QTL exceeded the genome-wide significance threshold, while 47 QTL reached the suggestive threshold. These QTL were located at 28 genomic regions on 16 autosomal chromosomes and QTL in 11 regions were significant at the genome-wide level. A QTL affecting pH value in loin was detected on SSC1 between marker-interval S0312-S0113 with strong statistical support (P < 3.0 x 10(-14)); this QTL was also associated with meat colour and conductivity. QTL for carcass composition and average daily gain was also found on SSC1, suggesting multiple QTL. Seventeen genomic segments had only a single QTL that reached at least suggestive significance. Forty QTL exhibited additive inheritance whereas 31 QTL showed (over-) dominance effects. Two QTL for trait backfat thickness were detected on SSC2; a significant paternal effect was found for a QTL in the IGF2 region while another QTL in the middle of SSC2 showed Mendelian expression.",

author = "G. Liu and D.G. Jennen and E. Tholen and H. Juengst and T. Kleinwachter and M. Holker and D. Tesfaye and G. Un and H.J. Schreinemachers and E. Murani and S. Ponsuksili and J.J. Kim and K. Schellander and K. Wimmers",

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doi = "10.1111/j.1365-2052.2007.01592.x",

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Liu, G, Jennen, DG, Tholen, E, Juengst, H, Kleinwachter, T, Holker, M, Tesfaye, D, Un, G, Schreinemachers, HJ, Murani, E, Ponsuksili, S, Kim, JJ, Schellander, K & Wimmers, K 2007, 'A genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc-Pietrain resource population', Animal Genetics, vol. 38, no. 3, pp. 241-252. https://doi.org/10.1111/j.1365-2052.2007.01592.x

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T1 - A genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc-Pietrain resource population

AU - Liu, G.

AU - Jennen, D.G.

AU - Tholen, E.

AU - Juengst, H.

AU - Kleinwachter, T.

AU - Holker, M.

AU - Tesfaye, D.

AU - Un, G.

AU - Schreinemachers, H.J.

AU - Murani, E.

AU - Ponsuksili, S.

AU - Kim, J.J.

AU - Schellander, K.

AU - Wimmers, K.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - We performed a genome-wide QTL scan for production traits in a line cross between Duroc and Pietrain breeds of pigs, which included 585 F(2) progeny produced from 31 full-sib families genotyped with 106 informative microsatellites. A linkage map covering all 18 autosomes and spanning 1987 Kosambi cM was constructed. Thirty-five phenotypic traits including body weight, growth, carcass composition and meat quality traits were analysed using least square regression interval mapping. Twenty-four QTL exceeded the genome-wide significance threshold, while 47 QTL reached the suggestive threshold. These QTL were located at 28 genomic regions on 16 autosomal chromosomes and QTL in 11 regions were significant at the genome-wide level. A QTL affecting pH value in loin was detected on SSC1 between marker-interval S0312-S0113 with strong statistical support (P < 3.0 x 10(-14)); this QTL was also associated with meat colour and conductivity. QTL for carcass composition and average daily gain was also found on SSC1, suggesting multiple QTL. Seventeen genomic segments had only a single QTL that reached at least suggestive significance. Forty QTL exhibited additive inheritance whereas 31 QTL showed (over-) dominance effects. Two QTL for trait backfat thickness were detected on SSC2; a significant paternal effect was found for a QTL in the IGF2 region while another QTL in the middle of SSC2 showed Mendelian expression.

AB - We performed a genome-wide QTL scan for production traits in a line cross between Duroc and Pietrain breeds of pigs, which included 585 F(2) progeny produced from 31 full-sib families genotyped with 106 informative microsatellites. A linkage map covering all 18 autosomes and spanning 1987 Kosambi cM was constructed. Thirty-five phenotypic traits including body weight, growth, carcass composition and meat quality traits were analysed using least square regression interval mapping. Twenty-four QTL exceeded the genome-wide significance threshold, while 47 QTL reached the suggestive threshold. These QTL were located at 28 genomic regions on 16 autosomal chromosomes and QTL in 11 regions were significant at the genome-wide level. A QTL affecting pH value in loin was detected on SSC1 between marker-interval S0312-S0113 with strong statistical support (P < 3.0 x 10(-14)); this QTL was also associated with meat colour and conductivity. QTL for carcass composition and average daily gain was also found on SSC1, suggesting multiple QTL. Seventeen genomic segments had only a single QTL that reached at least suggestive significance. Forty QTL exhibited additive inheritance whereas 31 QTL showed (over-) dominance effects. Two QTL for trait backfat thickness were detected on SSC2; a significant paternal effect was found for a QTL in the IGF2 region while another QTL in the middle of SSC2 showed Mendelian expression.

U2 - 10.1111/j.1365-2052.2007.01592.x

DO - 10.1111/j.1365-2052.2007.01592.x

M3 - Article

SN - 0268-9146

VL - 38

SP - 241

EP - 252

JO - Animal Genetics

JF - Animal Genetics

IS - 3

ER -