A gene variant near ATM affects the response to metformin and metformin plasma levels: a post hoc analysis of an RCT

Mattijs Out, Matthijs L. Becker, Ron H. van Schaik, Philippe Lehert, Coen D. Stehouwer, Adriaan Kooy

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)715-726
Number of pages12
JournalPharmacogenomics
Volume19
Issue number8
DOIs
Publication statusPublished - 1 Jun 2018

Keywords

  • ATM protein
  • dose-response relationship
  • drug
  • human
  • metformin
  • CATION TRANSPORTER 1
  • TYPE-2 DIABETES-MELLITUS
  • TOXIN EXTRUSION 1
  • ATAXIA-TELANGIECTASIA
  • INSULIN-RESISTANCE
  • GLYCEMIC RESPONSE
  • SLC47A1 GENE
  • PHARMACOKINETICS
  • OCT1
  • POLYMORPHISMS

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