A factor IX-deficient mouse model for hemophilia B gene therapy

LL Wang; M Zoppe; TM Hackeng; JH Griffin; Kuo-Fen Lee; IM Verma

doi:10.1073/pnas.94.21.11563

A factor IX-deficient mouse model for hemophilia B gene therapy

LL Wang
, M Zoppe
, TM Hackeng
, JH Griffin
, Kuo-Fen Lee
, IM Verma

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We have generated a mouse where the clotting factor IX (FIX) gene has been disrupted by homologous recombination. The FIX nullizygous (-/-) mouse was devoid of factor IX antigen in plasma, Consistent with the bleeding disorder, the factor IX coagulant activities for wild-type (+/+), heterozygous (+/-), and homozygous (-/-) mice were 92%, 53%, and

Original language	English
Pages (from-to)	11563-11566
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	94
Issue number	21
DOIs	https://doi.org/10.1073/pnas.94.21.11563
Publication status	Published - 14 Oct 1997
Externally published	Yes

Keywords

TRANSPLANTATION
ADENOVIRUS
LONG
DOGS
MICE

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https://europepmc.org/articles/pmc23538?pdf=renderLicence: Other

Cite this

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abstract = "We have generated a mouse where the clotting factor IX (FIX) gene has been disrupted by homologous recombination. The FIX nullizygous (-/-) mouse was devoid of factor IX antigen in plasma, Consistent with the bleeding disorder, the factor IX coagulant activities for wild-type (+/+), heterozygous (+/-), and homozygous (-/-) mice were 92\%, 53\%, and",

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AU - Zoppe, M

AU - Hackeng, TM

AU - Griffin, JH

AU - Lee, Kuo-Fen

AU - Verma, IM

PY - 1997/10/14

Y1 - 1997/10/14

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AB - We have generated a mouse where the clotting factor IX (FIX) gene has been disrupted by homologous recombination. The FIX nullizygous (-/-) mouse was devoid of factor IX antigen in plasma, Consistent with the bleeding disorder, the factor IX coagulant activities for wild-type (+/+), heterozygous (+/-), and homozygous (-/-) mice were 92%, 53%, and

KW - TRANSPLANTATION

KW - ADENOVIRUS

KW - LONG

KW - DOGS

KW - MICE

U2 - 10.1073/pnas.94.21.11563

DO - 10.1073/pnas.94.21.11563

M3 - Article

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JO - Proceedings of the National Academy of Sciences of the United States of America

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A factor IX-deficient mouse model for hemophilia B gene therapy

Abstract

Keywords

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