A European Respiratory Society technical standard: exhaled biomarkers in lung disease

Ildiko Horvath; Peter J. Barnes; Stelios Loukides; Peter J. Sterk; Marieann Hogman; Anna-Carin Olin; Anton Amann; Balazs Antus; Eugenio Baraldi; Andras Bikov; Agnes W. Boots; Lieuwe D. Bos; Paul Brinkman; Caterina Bucca; Giovanna E. Carpagnano; Massimo Corradi; Simona Cristescu; Johan C. de Jongste; Anh-Tuan Dinh-Xuan; Edward Dompeling; Niki Fens; Stephen Fowler; Jens M. Hohlfeld; Olaf Holz; Quirijn Jobsis; Kim Van De Kant; Hugo H. Knobel; Konstantinos Kostikas; Lauri Lehtimaki; Jon Lundberg; Paolo Montuschi; Alain Van Muylem; Giorgio Pennazza; Petra Reinhold; Fabio L. M. Ricciardolo; Philippe Rosias; Marco Santonico; Marc P. van der Schee; Frederik-Jan van Schooten; Antonio Spanevello; Thomy Tonia; Teunis J. Vink

doi:10.1183/13993003.00965-2016

A European Respiratory Society technical standard: exhaled biomarkers in lung disease

Ildiko Horvath^*, Peter J. Barnes, Stelios Loukides, Peter J. Sterk, Marieann Hogman, Anna-Carin Olin, Anton Amann, Balazs Antus, Eugenio Baraldi, Andras Bikov, Agnes W. Boots, Lieuwe D. Bos, Paul Brinkman, Caterina Bucca, Giovanna E. Carpagnano, Massimo Corradi, Simona Cristescu, Johan C. de Jongste, Anh-Tuan Dinh-Xuan, Edward DompelingNiki Fens, Stephen Fowler, Jens M. Hohlfeld, Olaf Holz, Quirijn Jobsis, Kim Van De Kant, Hugo H. Knobel, Konstantinos Kostikas, Lauri Lehtimaki, Jon Lundberg, Paolo Montuschi, Alain Van Muylem, Giorgio Pennazza, Petra Reinhold, Fabio L. M. Ricciardolo, Philippe Rosias, Marco Santonico, Marc P. van der Schee, Frederik-Jan van Schooten, Antonio Spanevello, Thomy Tonia, Teunis J. Vink

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FeNO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FeNO, new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management.

Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members.

Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised.

Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice.

Original language	English
Article number	1600965
Number of pages	26
Journal	European Respiratory Journal
Volume	49
Issue number	4
DOIs	https://doi.org/10.1183/13993003.00965-2016
Publication status	Published - Apr 2017

Keywords

VOLATILE ORGANIC-COMPOUNDS
BREATH CONDENSATE PH
NASAL NITRIC-OXIDE
OBSTRUCTIVE PULMONARY-DISEASE
PRIMARY CILIARY DYSKINESIA
EXTENDED NO ANALYSIS
MAGNETIC-RESONANCE-SPECTROSCOPY
MASS-SPECTROMETRIC ANALYSIS
SLEEP-APNEA SYNDROME
ELECTRONIC NOSE

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10.1183/13993003.00965-2016

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Horvath, I., Barnes, P. J., Loukides, S., Sterk, P. J., Hogman, M., Olin, A.-C., Amann, A., Antus, B., Baraldi, E., Bikov, A., Boots, A. W., Bos, L. D., Brinkman, P., Bucca, C., Carpagnano, G. E., Corradi, M., Cristescu, S., de Jongste, J. C., Dinh-Xuan, A.-T., ... Vink, T. J. (2017). A European Respiratory Society technical standard: exhaled biomarkers in lung disease. European Respiratory Journal, 49(4), Article 1600965. https://doi.org/10.1183/13993003.00965-2016

@article{f8bd23e78061430d8ec7f13211c2091d,

title = "A European Respiratory Society technical standard: exhaled biomarkers in lung disease",

abstract = "Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FeNO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FeNO, new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management.Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members.Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised.Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice.",

keywords = "VOLATILE ORGANIC-COMPOUNDS, BREATH CONDENSATE PH, NASAL NITRIC-OXIDE, OBSTRUCTIVE PULMONARY-DISEASE, PRIMARY CILIARY DYSKINESIA, EXTENDED NO ANALYSIS, MAGNETIC-RESONANCE-SPECTROSCOPY, MASS-SPECTROMETRIC ANALYSIS, SLEEP-APNEA SYNDROME, ELECTRONIC NOSE",

author = "Ildiko Horvath and Barnes, {Peter J.} and Stelios Loukides and Sterk, {Peter J.} and Marieann Hogman and Anna-Carin Olin and Anton Amann and Balazs Antus and Eugenio Baraldi and Andras Bikov and Boots, {Agnes W.} and Bos, {Lieuwe D.} and Paul Brinkman and Caterina Bucca and Carpagnano, {Giovanna E.} and Massimo Corradi and Simona Cristescu and {de Jongste}, {Johan C.} and Anh-Tuan Dinh-Xuan and Edward Dompeling and Niki Fens and Stephen Fowler and Hohlfeld, {Jens M.} and Olaf Holz and Quirijn Jobsis and {Van De Kant}, Kim and Knobel, {Hugo H.} and Konstantinos Kostikas and Lauri Lehtimaki and Jon Lundberg and Paolo Montuschi and {Van Muylem}, Alain and Giorgio Pennazza and Petra Reinhold and Ricciardolo, {Fabio L. M.} and Philippe Rosias and Marco Santonico and {van der Schee}, {Marc P.} and {van Schooten}, Frederik-Jan and Antonio Spanevello and Thomy Tonia and Vink, {Teunis J.}",

year = "2017",

month = apr,

doi = "10.1183/13993003.00965-2016",

language = "English",

volume = "49",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "4",

}

Horvath, I, Barnes, PJ, Loukides, S, Sterk, PJ, Hogman, M, Olin, A-C, Amann, A, Antus, B, Baraldi, E, Bikov, A, Boots, AW, Bos, LD, Brinkman, P, Bucca, C, Carpagnano, GE, Corradi, M, Cristescu, S, de Jongste, JC, Dinh-Xuan, A-T, Dompeling, E, Fens, N, Fowler, S, Hohlfeld, JM, Holz, O, Jobsis, Q , Van De Kant, K, Knobel, HH, Kostikas, K, Lehtimaki, L, Lundberg, J, Montuschi, P, Van Muylem, A, Pennazza, G, Reinhold, P, Ricciardolo, FLM, Rosias, P, Santonico, M, van der Schee, MP, van Schooten, F-J, Spanevello, A, Tonia, T & Vink, TJ 2017, 'A European Respiratory Society technical standard: exhaled biomarkers in lung disease', European Respiratory Journal, vol. 49, no. 4, 1600965. https://doi.org/10.1183/13993003.00965-2016

TY - JOUR

T1 - A European Respiratory Society technical standard

T2 - exhaled biomarkers in lung disease

AU - Horvath, Ildiko

AU - Barnes, Peter J.

AU - Loukides, Stelios

AU - Sterk, Peter J.

AU - Hogman, Marieann

AU - Olin, Anna-Carin

AU - Amann, Anton

AU - Antus, Balazs

AU - Baraldi, Eugenio

AU - Bikov, Andras

AU - Boots, Agnes W.

AU - Bos, Lieuwe D.

AU - Brinkman, Paul

AU - Bucca, Caterina

AU - Carpagnano, Giovanna E.

AU - Corradi, Massimo

AU - Cristescu, Simona

AU - de Jongste, Johan C.

AU - Dinh-Xuan, Anh-Tuan

AU - Dompeling, Edward

AU - Fens, Niki

AU - Fowler, Stephen

AU - Hohlfeld, Jens M.

AU - Holz, Olaf

AU - Jobsis, Quirijn

AU - Van De Kant, Kim

AU - Knobel, Hugo H.

AU - Kostikas, Konstantinos

AU - Lehtimaki, Lauri

AU - Lundberg, Jon

AU - Montuschi, Paolo

AU - Van Muylem, Alain

AU - Pennazza, Giorgio

AU - Reinhold, Petra

AU - Ricciardolo, Fabio L. M.

AU - Rosias, Philippe

AU - Santonico, Marco

AU - van der Schee, Marc P.

AU - van Schooten, Frederik-Jan

AU - Spanevello, Antonio

AU - Tonia, Thomy

AU - Vink, Teunis J.

PY - 2017/4

Y1 - 2017/4

N2 - Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FeNO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FeNO, new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management.Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members.Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised.Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice.

AB - Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FeNO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FeNO, new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management.Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members.Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised.Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice.

KW - VOLATILE ORGANIC-COMPOUNDS

KW - BREATH CONDENSATE PH

KW - NASAL NITRIC-OXIDE

KW - OBSTRUCTIVE PULMONARY-DISEASE

KW - PRIMARY CILIARY DYSKINESIA

KW - EXTENDED NO ANALYSIS

KW - MAGNETIC-RESONANCE-SPECTROSCOPY

KW - MASS-SPECTROMETRIC ANALYSIS

KW - SLEEP-APNEA SYNDROME

KW - ELECTRONIC NOSE

U2 - 10.1183/13993003.00965-2016

DO - 10.1183/13993003.00965-2016

M3 - Article

SN - 0903-1936

VL - 49

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 4

M1 - 1600965

ER -

A European Respiratory Society technical standard: exhaled biomarkers in lung disease

Abstract

Keywords

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