A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy

Linda M. Henricks; Carin A. T. C. Lunenburg; Femke M. de Man; Didier Meulendijks; Geert W. J. Frederix; Emma Kienhuis; Geert-Jan Creemers; Arnold Baars; Vincent O. Dezentje; Alexander L. T. Imholz; Frank J. F. Jeurissen; Johanna E. A. Portielje; Rob L. H. Jansen; Paul Hamberg; Albert J. ten Tije; Helga J. Droogendijk; Miriam Koopman; Peter Nieboer; Marlene H. W. van de Poel; Caroline M. P. W. Mandigers; Hilde Rosing; Jos H. Beijnen; Erik van Werkhoven; Andre B. P. van Kuilenburg; Ron H. N. van Schaik; Ron H. J. Mathijssen; Jesse J. Swen; Hans Gelderblom; Annemieke Cats; Henk-Jan Guchelaar; Jan H. M. Schellens

doi:10.1016/j.ejca.2018.11.010

A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy

Linda M. Henricks^*, Carin A. T. C. Lunenburg, Femke M. de Man, Didier Meulendijks, Geert W. J. Frederix, Emma Kienhuis, Geert-Jan Creemers, Arnold Baars, Vincent O. Dezentje, Alexander L. T. Imholz, Frank J. F. Jeurissen, Johanna E. A. Portielje, Rob L. H. Jansen, Paul Hamberg, Albert J. ten Tije, Helga J. Droogendijk, Miriam Koopman, Peter Nieboer, Marlene H. W. van de Poel, Caroline M. P. W. MandigersHilde Rosing, Jos H. Beijnen, Erik van Werkhoven, Andre B. P. van Kuilenburg, Ron H. N. van Schaik, Ron H. J. Mathijssen, Jesse J. Swen, Hans Gelderblom, Annemieke Cats, Henk-Jan Guchelaar, Jan H. M. Schellens

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Web of Science)

Original language	English
Pages (from-to)	60-67
Number of pages	8
Journal	European Journal of Cancer
Volume	107
DOIs	https://doi.org/10.1016/j.ejca.2018.11.010
Publication status	Published - Jan 2019

Keywords

Cost-analysis
Dihydropyrimidine dehydrogenase
DPYD
Pharmacogenetics
Fluoropyrimidines
Genotyping
Toxicity
FLUOROURACIL PLUS LEUCOVORIN
METASTATIC COLORECTAL-CANCER
ORAL CAPECITABINE
TOXICITY
5-FLUOROURACIL
DEFICIENCY
PREDICTOR

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10.1016/j.ejca.2018.11.010

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Henricks, L. M., Lunenburg, C. A. T. C., de Man, F. M., Meulendijks, D., Frederix, G. W. J., Kienhuis, E., Creemers, G-J., Baars, A., Dezentje, V. O., Imholz, A. L. T., Jeurissen, F. J. F., Portielje, J. E. A., Jansen, R. L. H., Hamberg, P., ten Tije, A. J., Droogendijk, H. J., Koopman, M., Nieboer, P., van de Poel, M. H. W., ... Schellens, J. H. M. (2019). A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy. European Journal of Cancer, 107, 60-67. https://doi.org/10.1016/j.ejca.2018.11.010

Henricks, Linda M. ; Lunenburg, Carin A. T. C. ; de Man, Femke M. ; Meulendijks, Didier ; Frederix, Geert W. J. ; Kienhuis, Emma ; Creemers, Geert-Jan ; Baars, Arnold ; Dezentje, Vincent O. ; Imholz, Alexander L. T. ; Jeurissen, Frank J. F. ; Portielje, Johanna E. A. ; Jansen, Rob L. H. ; Hamberg, Paul ; ten Tije, Albert J. ; Droogendijk, Helga J. ; Koopman, Miriam ; Nieboer, Peter ; van de Poel, Marlene H. W. ; Mandigers, Caroline M. P. W. ; Rosing, Hilde ; Beijnen, Jos H. ; van Werkhoven, Erik ; van Kuilenburg, Andre B. P. ; van Schaik, Ron H. N. ; Mathijssen, Ron H. J. ; Swen, Jesse J. ; Gelderblom, Hans ; Cats, Annemieke ; Guchelaar, Henk-Jan ; Schellens, Jan H. M. / A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy. In: European Journal of Cancer. 2019 ; Vol. 107. pp. 60-67.

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title = "A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy",

keywords = "Cost-analysis, Dihydropyrimidine dehydrogenase, DPYD, Pharmacogenetics, Fluoropyrimidines, Genotyping, Toxicity, FLUOROURACIL PLUS LEUCOVORIN, METASTATIC COLORECTAL-CANCER, ORAL CAPECITABINE, TOXICITY, 5-FLUOROURACIL, DEFICIENCY, PREDICTOR",

author = "Henricks, {Linda M.} and Lunenburg, {Carin A. T. C.} and {de Man}, {Femke M.} and Didier Meulendijks and Frederix, {Geert W. J.} and Emma Kienhuis and Geert-Jan Creemers and Arnold Baars and Dezentje, {Vincent O.} and Imholz, {Alexander L. T.} and Jeurissen, {Frank J. F.} and Portielje, {Johanna E. A.} and Jansen, {Rob L. H.} and Paul Hamberg and {ten Tije}, {Albert J.} and Droogendijk, {Helga J.} and Miriam Koopman and Peter Nieboer and {van de Poel}, {Marlene H. W.} and Mandigers, {Caroline M. P. W.} and Hilde Rosing and Beijnen, {Jos H.} and {van Werkhoven}, Erik and {van Kuilenburg}, {Andre B. P.} and {van Schaik}, {Ron H. N.} and Mathijssen, {Ron H. J.} and Swen, {Jesse J.} and Hans Gelderblom and Annemieke Cats and Henk-Jan Guchelaar and Schellens, {Jan H. M.}",

year = "2019",

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doi = "10.1016/j.ejca.2018.11.010",

language = "English",

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Henricks, LM, Lunenburg, CATC, de Man, FM, Meulendijks, D, Frederix, GWJ, Kienhuis, E, Creemers, G-J, Baars, A, Dezentje, VO, Imholz, ALT, Jeurissen, FJF, Portielje, JEA, Jansen, RLH, Hamberg, P, ten Tije, AJ, Droogendijk, HJ, Koopman, M, Nieboer, P, van de Poel, MHW, Mandigers, CMPW, Rosing, H, Beijnen, JH, van Werkhoven, E, van Kuilenburg, ABP, van Schaik, RHN, Mathijssen, RHJ, Swen, JJ, Gelderblom, H, Cats, A, Guchelaar, H-J & Schellens, JHM 2019, 'A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy', European Journal of Cancer, vol. 107, pp. 60-67. https://doi.org/10.1016/j.ejca.2018.11.010

A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy. / Henricks, Linda M.; Lunenburg, Carin A. T. C.; de Man, Femke M.; Meulendijks, Didier; Frederix, Geert W. J.; Kienhuis, Emma; Creemers, Geert-Jan; Baars, Arnold; Dezentje, Vincent O.; Imholz, Alexander L. T.; Jeurissen, Frank J. F.; Portielje, Johanna E. A.; Jansen, Rob L. H.; Hamberg, Paul; ten Tije, Albert J.; Droogendijk, Helga J.; Koopman, Miriam; Nieboer, Peter; van de Poel, Marlene H. W.; Mandigers, Caroline M. P. W.; Rosing, Hilde; Beijnen, Jos H.; van Werkhoven, Erik; van Kuilenburg, Andre B. P.; van Schaik, Ron H. N.; Mathijssen, Ron H. J.; Swen, Jesse J.; Gelderblom, Hans; Cats, Annemieke; Guchelaar, Henk-Jan; Schellens, Jan H. M.

In: European Journal of Cancer, Vol. 107, 01.2019, p. 60-67.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy

AU - Henricks, Linda M.

AU - Lunenburg, Carin A. T. C.

AU - de Man, Femke M.

AU - Meulendijks, Didier

AU - Frederix, Geert W. J.

AU - Kienhuis, Emma

AU - Creemers, Geert-Jan

AU - Baars, Arnold

AU - Dezentje, Vincent O.

AU - Imholz, Alexander L. T.

AU - Jeurissen, Frank J. F.

AU - Portielje, Johanna E. A.

AU - Jansen, Rob L. H.

AU - Hamberg, Paul

AU - ten Tije, Albert J.

AU - Droogendijk, Helga J.

AU - Koopman, Miriam

AU - Nieboer, Peter

AU - van de Poel, Marlene H. W.

AU - Mandigers, Caroline M. P. W.

AU - Rosing, Hilde

AU - Beijnen, Jos H.

AU - van Werkhoven, Erik

AU - van Kuilenburg, Andre B. P.

AU - van Schaik, Ron H. N.

AU - Mathijssen, Ron H. J.

AU - Swen, Jesse J.

AU - Gelderblom, Hans

AU - Cats, Annemieke

AU - Guchelaar, Henk-Jan

AU - Schellens, Jan H. M.

PY - 2019/1

Y1 - 2019/1

KW - Cost-analysis

KW - Dihydropyrimidine dehydrogenase

KW - DPYD

KW - Pharmacogenetics

KW - Fluoropyrimidines

KW - Genotyping

KW - Toxicity

KW - FLUOROURACIL PLUS LEUCOVORIN

KW - METASTATIC COLORECTAL-CANCER

KW - ORAL CAPECITABINE

KW - TOXICITY

KW - 5-FLUOROURACIL

KW - DEFICIENCY

KW - PREDICTOR

U2 - 10.1016/j.ejca.2018.11.010

DO - 10.1016/j.ejca.2018.11.010

M3 - Article

VL - 107

SP - 60

EP - 67

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

ER -