A controlled trial with vasopressin analogue (DGAW) on cognitive recovery immediately after head trauma

Nicolaas J. Bohnen; Albert Twijnstra; Jellemer Jolles

doi:10.1212/WNL.43.1_Part_1.103

A controlled trial with vasopressin analogue (DGAW) on cognitive recovery immediately after head trauma

Nicolaas J. Bohnen^*
, Albert Twijnstra
, Jellemer Jolles

^*Corresponding author for this work

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Abstract

Recent evidence suggests that the vasopressin analogue desglycinamide-arginine8-vasopressin (DGAVP) might specifically benefit mild brain trauma patients. We investigated the effect of intranasal DGAVP treatment in 32 patients who had sustained a mild head injury for 3 months in a double-blind, placebo-controlled, matched-pairs study. DGAVP did not have a positive effect on cognitive recovery in this group of mildly affected patients.

Original language	English
Pages (from-to)	103-106
Number of pages	4
Journal	Neurology
Volume	43
Issue number	1
DOIs	https://doi.org/10.1212/WNL.43.1_Part_1.103
Publication status	Published - 1 Jan 1993

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abstract = "Recent evidence suggests that the vasopressin analogue desglycinamide-arginine8-vasopressin (DGAVP) might specifically benefit mild brain trauma patients. We investigated the effect of intranasal DGAVP treatment in 32 patients who had sustained a mild head injury for 3 months in a double-blind, placebo-controlled, matched-pairs study. DGAVP did not have a positive effect on cognitive recovery in this group of mildly affected patients.",

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AB - Recent evidence suggests that the vasopressin analogue desglycinamide-arginine8-vasopressin (DGAVP) might specifically benefit mild brain trauma patients. We investigated the effect of intranasal DGAVP treatment in 32 patients who had sustained a mild head injury for 3 months in a double-blind, placebo-controlled, matched-pairs study. DGAVP did not have a positive effect on cognitive recovery in this group of mildly affected patients.

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A controlled trial with vasopressin analogue (DGAW) on cognitive recovery immediately after head trauma

Abstract

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