A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease

Frank Jessen; Rebecca E. Amariglio; Martin van Boxtel; Monique Breteler; Mathieu Ceccaldi; Gael Chetelat; Bruno Dubois; Carole Dufouil; Kathryn A. Ellis; Wiesje M. van der Flier; Lidia Glodzik; Argonde C. van Harten; Mony J. de Leon; Pauline McHugh; Michelle M. Mielke; Jose Luis Molinuevo; Lisa Mosconi; Ricardo S. Osorio; Audrey Perrotin; Ronald C. Petersen; Laura A. Rabin; Lorena Rami; Barry Reisberg; Dorene M. Rentz; Perminder S. Sachdev; Vincent de la Sayette; Andrew J. Saykin; Philip Scheltens; Melanie B. Shulman; Melissa J. Slavin; Reisa A. Sperling; Robert Stewart; Olga Uspenskaya; Bruno Vellas; Pieter Jelle Visser; Michael Wagner

doi:10.1016/j.jalz.2014.01.001

A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease

Frank Jessen^*, Rebecca E. Amariglio, Martin van Boxtel, Monique Breteler, Mathieu Ceccaldi, Gael Chetelat, Bruno Dubois, Carole Dufouil, Kathryn A. Ellis, Wiesje M. van der Flier, Lidia Glodzik, Argonde C. van Harten, Mony J. de Leon, Pauline McHugh, Michelle M. Mielke, Jose Luis Molinuevo, Lisa Mosconi, Ricardo S. Osorio, Audrey Perrotin, Ronald C. PetersenLaura A. Rabin, Lorena Rami, Barry Reisberg, Dorene M. Rentz, Perminder S. Sachdev, Vincent de la Sayette, Andrew J. Saykin, Philip Scheltens, Melanie B. Shulman, Melissa J. Slavin, Reisa A. Sperling, Robert Stewart, Olga Uspenskaya, Bruno Vellas, Pieter Jelle Visser, Michael Wagner

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD plus.

Original language	English
Pages (from-to)	844-852
Journal	Alzheimer's & Dementia
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/j.jalz.2014.01.001
Publication status	Published - Nov 2014

Keywords

Alzheimer's disease
Subjective cognitive decline
Preclinical Alzheimer's disease
Mild cognitive impairment
Prodromal Alzheimer's disease
Research criteria

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10.1016/j.jalz.2014.01.001

Cite this

Jessen, F., Amariglio, R. E., van Boxtel, M., Breteler, M., Ceccaldi, M., Chetelat, G., Dubois, B., Dufouil, C., Ellis, K. A., van der Flier, W. M., Glodzik, L., van Harten, A. C., de Leon, M. J., McHugh, P., Mielke, M. M., Molinuevo, J. L., Mosconi, L., Osorio, R. S., Perrotin, A., ... Wagner, M. (2014). A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimer's & Dementia, 10(6), 844-852. https://doi.org/10.1016/j.jalz.2014.01.001

@article{ef976321d9af4f66b1f23f7516be139c,

title = "A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease",

abstract = "There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD plus. ",

keywords = "Alzheimer's disease, Subjective cognitive decline, Preclinical Alzheimer's disease, Mild cognitive impairment, Prodromal Alzheimer's disease, Research criteria",

author = "Frank Jessen and Amariglio, {Rebecca E.} and {van Boxtel}, Martin and Monique Breteler and Mathieu Ceccaldi and Gael Chetelat and Bruno Dubois and Carole Dufouil and Ellis, {Kathryn A.} and {van der Flier}, {Wiesje M.} and Lidia Glodzik and {van Harten}, {Argonde C.} and {de Leon}, {Mony J.} and Pauline McHugh and Mielke, {Michelle M.} and Molinuevo, {Jose Luis} and Lisa Mosconi and Osorio, {Ricardo S.} and Audrey Perrotin and Petersen, {Ronald C.} and Rabin, {Laura A.} and Lorena Rami and Barry Reisberg and Rentz, {Dorene M.} and Sachdev, {Perminder S.} and {de la Sayette}, Vincent and Saykin, {Andrew J.} and Philip Scheltens and Shulman, {Melanie B.} and Slavin, {Melissa J.} and Sperling, {Reisa A.} and Robert Stewart and Olga Uspenskaya and Bruno Vellas and Visser, {Pieter Jelle} and Michael Wagner",

year = "2014",

month = nov,

doi = "10.1016/j.jalz.2014.01.001",

language = "English",

volume = "10",

pages = "844--852",

journal = "Alzheimer's & Dementia",

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publisher = "Elsevier Science",

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Jessen, F, Amariglio, RE, van Boxtel, M, Breteler, M, Ceccaldi, M, Chetelat, G, Dubois, B, Dufouil, C, Ellis, KA, van der Flier, WM, Glodzik, L, van Harten, AC, de Leon, MJ, McHugh, P, Mielke, MM, Molinuevo, JL, Mosconi, L, Osorio, RS, Perrotin, A, Petersen, RC, Rabin, LA, Rami, L, Reisberg, B, Rentz, DM, Sachdev, PS, de la Sayette, V, Saykin, AJ, Scheltens, P, Shulman, MB, Slavin, MJ, Sperling, RA, Stewart, R, Uspenskaya, O, Vellas, B, Visser, PJ & Wagner, M 2014, 'A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease', Alzheimer's & Dementia, vol. 10, no. 6, pp. 844-852. https://doi.org/10.1016/j.jalz.2014.01.001

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T1 - A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease

AU - Jessen, Frank

AU - Amariglio, Rebecca E.

AU - van Boxtel, Martin

AU - Breteler, Monique

AU - Ceccaldi, Mathieu

AU - Chetelat, Gael

AU - Dubois, Bruno

AU - Dufouil, Carole

AU - Ellis, Kathryn A.

AU - van der Flier, Wiesje M.

AU - Glodzik, Lidia

AU - van Harten, Argonde C.

AU - de Leon, Mony J.

AU - McHugh, Pauline

AU - Mielke, Michelle M.

AU - Molinuevo, Jose Luis

AU - Mosconi, Lisa

AU - Osorio, Ricardo S.

AU - Perrotin, Audrey

AU - Petersen, Ronald C.

AU - Rabin, Laura A.

AU - Rami, Lorena

AU - Reisberg, Barry

AU - Rentz, Dorene M.

AU - Sachdev, Perminder S.

AU - de la Sayette, Vincent

AU - Saykin, Andrew J.

AU - Scheltens, Philip

AU - Shulman, Melanie B.

AU - Slavin, Melissa J.

AU - Sperling, Reisa A.

AU - Stewart, Robert

AU - Uspenskaya, Olga

AU - Vellas, Bruno

AU - Visser, Pieter Jelle

AU - Wagner, Michael

PY - 2014/11

Y1 - 2014/11

N2 - There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD plus.

AB - There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD plus.

KW - Alzheimer's disease

KW - Subjective cognitive decline

KW - Preclinical Alzheimer's disease

KW - Mild cognitive impairment

KW - Prodromal Alzheimer's disease

KW - Research criteria

U2 - 10.1016/j.jalz.2014.01.001

DO - 10.1016/j.jalz.2014.01.001

M3 - Article

C2 - 24798886

SN - 1552-5260

VL - 10

SP - 844

EP - 852

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 6

ER -