After preconstriction of rat aortic rings by norepinephrine (NE; 5*10(-5) M) or by high potassium (K+; 3*10(-2) M), a dose-dependent relaxation was induced by enoximone (E) in a range of 1*10(-5) M - 2*10(-4) M. The time to 50% dilatation was constant in that range, with mean values of 2.2 (NE) and 3.8 (K+) minutes. Also dibutyryl cyclic AMP (Db cAMP) in a range of 6*10(-5) M - 2*10(-3) M produced a dose-dependent relaxation. Comparison of the concentrations of E and Db cAMP producing equal extent of vasorelaxation demonstrated that inhibition of phosphodiesterase with E proved to be more effective than adding Db cAMP in equimolar dose.
|Journal||Research Communications in Molecular Pathology and Pharmacology|
|Publication status||Published - 1 Jan 1990|