A comparison of the vasorelaxant effects of enoximone and dibutyryl cyclic AMP measured in rat aortic rings

D.H. Schweitzer, G.H. Koek, A.E. Meinders, A. van der Laarse

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After preconstriction of rat aortic rings by norepinephrine (NE; 5*10(-5) M) or by high potassium (K+; 3*10(-2) M), a dose-dependent relaxation was induced by enoximone (E) in a range of 1*10(-5) M - 2*10(-4) M. The time to 50% dilatation was constant in that range, with mean values of 2.2 (NE) and 3.8 (K+) minutes. Also dibutyryl cyclic AMP (Db cAMP) in a range of 6*10(-5) M - 2*10(-3) M produced a dose-dependent relaxation. Comparison of the concentrations of E and Db cAMP producing equal extent of vasorelaxation demonstrated that inhibition of phosphodiesterase with E proved to be more effective than adding Db cAMP in equimolar dose.
Original languageEnglish
Pages (from-to)291-7
JournalResearch Communications in Molecular Pathology and Pharmacology
Issue number3
Publication statusPublished - 1 Jan 1990

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