A comparison of the vasorelaxant effects of enoximone and dibutyryl cyclic AMP measured in rat aortic rings

D.H. Schweitzer; G.H. Koek; A.E. Meinders; A. van der Laarse

A comparison of the vasorelaxant effects of enoximone and dibutyryl cyclic AMP measured in rat aortic rings

D.H. Schweitzer, G.H. Koek, A.E. Meinders, A. van der Laarse

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

After preconstriction of rat aortic rings by norepinephrine (NE; 5*10(-5) M) or by high potassium (K+; 3*10(-2) M), a dose-dependent relaxation was induced by enoximone (E) in a range of 1*10(-5) M - 2*10(-4) M. The time to 50% dilatation was constant in that range, with mean values of 2.2 (NE) and 3.8 (K+) minutes. Also dibutyryl cyclic AMP (Db cAMP) in a range of 6*10(-5) M - 2*10(-3) M produced a dose-dependent relaxation. Comparison of the concentrations of E and Db cAMP producing equal extent of vasorelaxation demonstrated that inhibition of phosphodiesterase with E proved to be more effective than adding Db cAMP in equimolar dose.

Original language	English
Pages (from-to)	291-7
Journal	Research Communications in Molecular Pathology and Pharmacology
Volume	68
Issue number	3
Publication status	Published - 1 Jan 1990

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Cite this

@article{f7fda32238984c1fb8edf4682652d562,

title = "A comparison of the vasorelaxant effects of enoximone and dibutyryl cyclic AMP measured in rat aortic rings",

abstract = "After preconstriction of rat aortic rings by norepinephrine (NE; 5*10(-5) M) or by high potassium (K+; 3*10(-2) M), a dose-dependent relaxation was induced by enoximone (E) in a range of 1*10(-5) M - 2*10(-4) M. The time to 50% dilatation was constant in that range, with mean values of 2.2 (NE) and 3.8 (K+) minutes. Also dibutyryl cyclic AMP (Db cAMP) in a range of 6*10(-5) M - 2*10(-3) M produced a dose-dependent relaxation. Comparison of the concentrations of E and Db cAMP producing equal extent of vasorelaxation demonstrated that inhibition of phosphodiesterase with E proved to be more effective than adding Db cAMP in equimolar dose.",

author = "D.H. Schweitzer and G.H. Koek and A.E. Meinders and {van der Laarse}, A.",

year = "1990",

month = jan,

day = "1",

language = "English",

volume = "68",

pages = "291--7",

journal = "Research Communications in Molecular Pathology and Pharmacology",

issn = "1078-0297",

publisher = "PJD Publications Ltd",

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Schweitzer, DH, Koek, GH, Meinders, AE & van der Laarse, A 1990, 'A comparison of the vasorelaxant effects of enoximone and dibutyryl cyclic AMP measured in rat aortic rings', Research Communications in Molecular Pathology and Pharmacology, vol. 68, no. 3, pp. 291-7. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2166964>

TY - JOUR

T1 - A comparison of the vasorelaxant effects of enoximone and dibutyryl cyclic AMP measured in rat aortic rings

AU - Schweitzer, D.H.

AU - Koek, G.H.

AU - Meinders, A.E.

AU - van der Laarse, A.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - After preconstriction of rat aortic rings by norepinephrine (NE; 5*10(-5) M) or by high potassium (K+; 3*10(-2) M), a dose-dependent relaxation was induced by enoximone (E) in a range of 1*10(-5) M - 2*10(-4) M. The time to 50% dilatation was constant in that range, with mean values of 2.2 (NE) and 3.8 (K+) minutes. Also dibutyryl cyclic AMP (Db cAMP) in a range of 6*10(-5) M - 2*10(-3) M produced a dose-dependent relaxation. Comparison of the concentrations of E and Db cAMP producing equal extent of vasorelaxation demonstrated that inhibition of phosphodiesterase with E proved to be more effective than adding Db cAMP in equimolar dose.

AB - After preconstriction of rat aortic rings by norepinephrine (NE; 5*10(-5) M) or by high potassium (K+; 3*10(-2) M), a dose-dependent relaxation was induced by enoximone (E) in a range of 1*10(-5) M - 2*10(-4) M. The time to 50% dilatation was constant in that range, with mean values of 2.2 (NE) and 3.8 (K+) minutes. Also dibutyryl cyclic AMP (Db cAMP) in a range of 6*10(-5) M - 2*10(-3) M produced a dose-dependent relaxation. Comparison of the concentrations of E and Db cAMP producing equal extent of vasorelaxation demonstrated that inhibition of phosphodiesterase with E proved to be more effective than adding Db cAMP in equimolar dose.

M3 - Article

SN - 1078-0297

VL - 68

SP - 291

EP - 297

JO - Research Communications in Molecular Pathology and Pharmacology

JF - Research Communications in Molecular Pathology and Pharmacology

IS - 3

ER -