A comparison of the responsiveness of EQ-5D-5L and the QOLIE-31P and mapping of QOLIE-31P to EQ-5D-5L in epilepsy

Ben F. M. Wijnen*, Iris Mosweu, Marian H. J. M. Majoie, Leone Ridsdale, Reina J. A. de Kinderen, Silvia M. A. A. Evers, Paul McCrone

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE: To investigate the responsiveness of and correlation between the EQ-5D-5L and the QOLIE-31P in patients with epilepsy, and develop a mapping function to predict EQ-5D-5L values based on the QOLIE-31P for use in economic evaluations.

METHODS: The dataset was derived from two clinical trials, the ZMILE study in the Netherlands and the SMILE study in the UK. In both studies, patients' quality of life using the EQ-5D-5L and QOLIE-31P was measured at baseline and 12 months follow-up. Spearman's correlations, effect sizes (EF) and standardized response means (SRM) were calculated for both the EQ-5D-5L and QOLIE-31P domains and sub scores. Mapping functions were derived using ordinary least square (OLS) and censored least absolute deviations models.

RESULTS: A total of 509 patients were included in this study. Low to moderately strong significant correlations were found between both instruments. The EQ-5D-5L showed high ceiling effects and small EFs and SRMs, whereas the QOLIE-31P did not show ceiling effects and also showed small to moderate EFs and SRMs. Results of the different mapping functions indicate that the highest adjusted R 2 we were able to regress was 0.265 using an OLS model with squared terms, leading to a mean absolute error of 0.103.

CONCLUSIONS: Results presented in this study emphasize the shortcomings of the EQ-5D-5L in epilepsy and the importance of the development of condition-specific preference-based instruments which can be used within the QALY framework. In addition, the usefulness of the constructed mapping function in economic evaluations is questionable.

Original languageEnglish
Pages (from-to)861-870
Number of pages10
JournalEuropean Journal of Health Economics
Volume19
Issue number6
DOIs
Publication statusPublished - Jul 2018

Keywords

  • Mapping
  • Responsiveness
  • Quality of life
  • Epilepsy
  • QUALITY-OF-LIFE
  • RANDOMIZED CONTROLLED-TRIAL
  • SELF-MANAGEMENT EDUCATION
  • PREFERENCE-BASED MEASURES
  • DECISION-MAKING
  • HEALTH OUTCOMES
  • SMILE UK
  • INSTRUMENTS
  • ADULTS
  • INDEX
  • Humans
  • Middle Aged
  • Male
  • Young Adult
  • Netherlands
  • Adult
  • Female
  • Surveys and Questionnaires
  • Reproducibility of Results
  • Epilepsy/economics
  • Psychometrics
  • Adolescent
  • Quality of Life
  • Aged

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