A comparison of the diagnostic ability of vessel density and structural measurements of optical coherence tomography in primary open angle glaucoma

Harsha L. Rao*, Zia S. Pradhan, Robert N. Weinreb, Mohammed Riyazuddin, Srilakshmi Dasari, Jayasree P. Venugopal, Narendra K. Puttaiah, Dhanaraj A. S. Rao, Sathi Devi, Kaweh Mansouri, Carroll A. B. Webers

*Corresponding author for this work

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Abstract

Purpose

To compare the diagnostic abilities of vessel density measurements of the optic nerve head (ONH), peripapillary and macular regions on optical coherence tomography (OCT) angiography in eyes with primary open angle glaucoma (POAG) with that of the ONH rim area, peripapillary retinal nerve fiber layer (RNFL) thickness and the macular ganglion cell complex (GCC) thickness measurements.

Methods

In a cross sectional study, 78 eyes of 50 control subjects and 117 eyes of 67 POAG patients underwent vessel density and structural measurements with spectral domain OCT. POAG was diagnosed based on the masked evaluation of optic disc stereo photographs. Area under receiver operating characteristic curves (AUC) and sensitivities at fixed specificities of vessel densities in ONH, peripapillary and macular regions were compared with rim area, RNFL and GCC thickness.

Results

The AUC (sensitivity at 95% specificity) of average vessel densities within the ONH, peripapillary and macular region were 0.77 (31%), 0.85 (56%) and 0.70 (18%) respectively. The same of ONH rim area, average RNFL and GCC thickness were 0.94 (83%), 0.95 (72%) and 0.93 (62%) respectively. AUCs of vessel densities were significantly lower (p

Conclusions

Diagnostic abilities of ONH, peripapillary and the macular vessel densities in POAG were significantly lower than ONH rim area, peripapillary RNFL and macular GCC measurements respectively. At fixed levels of glaucoma severity, the diagnostic ability of the ONH vessel density was significantly greater in eyes with higher pre-treatment IOP.

Original languageEnglish
Article number0173930
Number of pages13
JournalPLOS ONE
Volume12
Issue number3
DOIs
Publication statusPublished - 13 Mar 2017

Keywords

  • NORMAL-TENSION GLAUCOMA
  • REGRESSION-ANALYSIS
  • DISC PERFUSION
  • SPECTRUM BIAS
  • VISUAL-FIELD
  • ANGIOGRAPHY
  • ACCURACY
  • EYES
  • PATHOPHYSIOLOGY
  • SEVERITY

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