A comparison of the corneal biomechanics in pseudoexfoliation glaucoma, primary open-angle glaucoma and healthy controls using Corvis ST

Zia Sultan Pradhan; Sujit Deshmukh; Shivani Dixit; Shruthi Sreenivasaiah; Sujani Shroff; Sathi Devi; Carroll A. B. Webers; Harsha Laxmana Rao

doi:10.1371/journal.pone.0241296

A comparison of the corneal biomechanics in pseudoexfoliation glaucoma, primary open-angle glaucoma and healthy controls using Corvis ST

Zia Sultan Pradhan^*, Sujit Deshmukh, Shivani Dixit, Shruthi Sreenivasaiah, Sujani Shroff, Sathi Devi, Carroll A. B. Webers, Harsha Laxmana Rao

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose

To compare the corneal biomechanical parameters between pseudoexfoliation glaucoma (PXG), primary open-angle glaucoma (POAG) and healthy controls using Corvis ST.

Methods

A prospective, cross-sectional study was conducted which included 132 treatment-naive eyes which underwent Corvis ST. The study cohort comprised of 44 eyes with PXG, 42 eyes with POAG and 46 healthy controls. Corneal biomechanical parameters, which included corneal velocities, length of corneal applanated surface, deformation amplitude (DA), peak distance and radius of curvature, were compared between the groups using analysis of variance models.

Results

The 3 groups were demographically similar. The mean IOP was 15.7 +/- 3 mmHg in the control group, 21.3 +/- 5 mmHg in the POAG group and 25.8 +/- 7 mmHg in the PXG group (p

Conclusion

Corneal biomechanical parameters measured on Corvis ST are not different between eyes with PXG, POAG and healthy controls after adjusting for IOP.

Original language	English
Article number	e0241296
Number of pages	10
Journal	PLOS ONE
Volume	15
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0241296
Publication status	Published - 26 Oct 2020

Keywords

EXFOLIATION SYNDROME
INTRAOCULAR-PRESSURE
DEFORMATION RESPONSE
HYSTERESIS
PARAMETERS
NUMBER
IMPACT
EYES

Access to Document

10.1371/journal.pone.0241296Licence: CC BY

Cite this

@article{a763612388674ee1b2e0ac00f7c59990,

title = "A comparison of the corneal biomechanics in pseudoexfoliation glaucoma, primary open-angle glaucoma and healthy controls using Corvis ST",

abstract = "PurposeTo compare the corneal biomechanical parameters between pseudoexfoliation glaucoma (PXG), primary open-angle glaucoma (POAG) and healthy controls using Corvis ST.MethodsA prospective, cross-sectional study was conducted which included 132 treatment-naive eyes which underwent Corvis ST. The study cohort comprised of 44 eyes with PXG, 42 eyes with POAG and 46 healthy controls. Corneal biomechanical parameters, which included corneal velocities, length of corneal applanated surface, deformation amplitude (DA), peak distance and radius of curvature, were compared between the groups using analysis of variance models.ResultsThe 3 groups were demographically similar. The mean IOP was 15.7 +/- 3 mmHg in the control group, 21.3 +/- 5 mmHg in the POAG group and 25.8 +/- 7 mmHg in the PXG group (pConclusionCorneal biomechanical parameters measured on Corvis ST are not different between eyes with PXG, POAG and healthy controls after adjusting for IOP.",

keywords = "EXFOLIATION SYNDROME, INTRAOCULAR-PRESSURE, DEFORMATION RESPONSE, HYSTERESIS, PARAMETERS, NUMBER, IMPACT, EYES",

author = "Pradhan, {Zia Sultan} and Sujit Deshmukh and Shivani Dixit and Shruthi Sreenivasaiah and Sujani Shroff and Sathi Devi and Webers, {Carroll A. B.} and Rao, {Harsha Laxmana}",

note = "Publisher Copyright: {\textcopyright} 2020 Pradhan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2020",

month = oct,

day = "26",

doi = "10.1371/journal.pone.0241296",

language = "English",

volume = "15",

journal = "PLOS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "10",

}

TY - JOUR

T1 - A comparison of the corneal biomechanics in pseudoexfoliation glaucoma, primary open-angle glaucoma and healthy controls using Corvis ST

AU - Pradhan, Zia Sultan

AU - Deshmukh, Sujit

AU - Dixit, Shivani

AU - Sreenivasaiah, Shruthi

AU - Shroff, Sujani

AU - Devi, Sathi

AU - Webers, Carroll A. B.

AU - Rao, Harsha Laxmana

N1 - Publisher Copyright: © 2020 Pradhan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2020/10/26

Y1 - 2020/10/26

N2 - PurposeTo compare the corneal biomechanical parameters between pseudoexfoliation glaucoma (PXG), primary open-angle glaucoma (POAG) and healthy controls using Corvis ST.MethodsA prospective, cross-sectional study was conducted which included 132 treatment-naive eyes which underwent Corvis ST. The study cohort comprised of 44 eyes with PXG, 42 eyes with POAG and 46 healthy controls. Corneal biomechanical parameters, which included corneal velocities, length of corneal applanated surface, deformation amplitude (DA), peak distance and radius of curvature, were compared between the groups using analysis of variance models.ResultsThe 3 groups were demographically similar. The mean IOP was 15.7 +/- 3 mmHg in the control group, 21.3 +/- 5 mmHg in the POAG group and 25.8 +/- 7 mmHg in the PXG group (pConclusionCorneal biomechanical parameters measured on Corvis ST are not different between eyes with PXG, POAG and healthy controls after adjusting for IOP.

AB - PurposeTo compare the corneal biomechanical parameters between pseudoexfoliation glaucoma (PXG), primary open-angle glaucoma (POAG) and healthy controls using Corvis ST.MethodsA prospective, cross-sectional study was conducted which included 132 treatment-naive eyes which underwent Corvis ST. The study cohort comprised of 44 eyes with PXG, 42 eyes with POAG and 46 healthy controls. Corneal biomechanical parameters, which included corneal velocities, length of corneal applanated surface, deformation amplitude (DA), peak distance and radius of curvature, were compared between the groups using analysis of variance models.ResultsThe 3 groups were demographically similar. The mean IOP was 15.7 +/- 3 mmHg in the control group, 21.3 +/- 5 mmHg in the POAG group and 25.8 +/- 7 mmHg in the PXG group (pConclusionCorneal biomechanical parameters measured on Corvis ST are not different between eyes with PXG, POAG and healthy controls after adjusting for IOP.

KW - EXFOLIATION SYNDROME

KW - INTRAOCULAR-PRESSURE

KW - DEFORMATION RESPONSE

KW - HYSTERESIS

KW - PARAMETERS

KW - NUMBER

KW - IMPACT

KW - EYES

U2 - 10.1371/journal.pone.0241296

DO - 10.1371/journal.pone.0241296

M3 - Article

C2 - 33104764

SN - 1932-6203

VL - 15

JO - PLOS ONE

JF - PLOS ONE

IS - 10

M1 - e0241296

ER -