A Comparison of Quality of Life in Elderly Patients with Intermittent Claudication and Chronic Limb-Threatening Ischemia

Joost P Roijers; Marijn M van den Houten; Niels J Hopmans; Patrick W H E Vriens; Edith M Willigendael; Paul Lodder; Jolanda de Vries; Joep A Teijink; Lijckle van der Laan

doi:10.1016/j.avsg.2020.05.048

A Comparison of Quality of Life in Elderly Patients with Intermittent Claudication and Chronic Limb-Threatening Ischemia

Joost P Roijers^*, Marijn M van den Houten, Niels J Hopmans, Patrick W H E Vriens, Edith M Willigendael, Paul Lodder, Jolanda de Vries, Joep A Teijink, Lijckle van der Laan

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: Intermittent claudication (IC) and chronic limb-threatening ischemia (CLTI) are both associated with a decreased health status and possibly quality of life (QOL). A better understanding of the differences in QOL between patients with IC and CLTI could be of additional value in shared decision-making. The aim of this study was to compare the QOL at baseline between patients with IC and patients with CLTI.

METHODS: The study population was based on 2 study cohorts, 1 cohort consisted of patients with IC (ELECT registry) and the other cohort of patients with CLTI (KOP-study). Patients with an age of ≥70 years were included. QOL at baseline was measured by the WHOQOL-BREF questionnaire. Nonresponders were excluded from data analyses. Student's t-tests and analysis of covariance (ANCOVA) analyses were used to compare QOL between the 2 groups. Outcomes of the ANCOVA analyses were expressed as estimated marginal means.

RESULTS: In total, 308 patients were included, 115 patients with IC and 193 patients with CLTI. Patients with CLTI were older (median age 80 years vs. 75 years, P < 0.001) and had more comorbidities. Patients with IC had a statistically significant higher QOL regarding physical health (mean 13.7 [standard deviation (SD) 2.3] vs. 10.8 [SD 2.8], P < 0.001), psychological health (mean 15.3 [SD 2.1] vs. 14.1 [SD 2.4], P < 0.001), environment (mean 16.3 [SD 2.4] vs. 15.5 [SD 2.0], P < 0.002), and the overall domain (mean 3.5 [SD 0.7] vs. 3.1 [SD 0.9], P < 0.001). After correcting for the confounding effect of age and sex, patients with IC still had a statistically significant higher QOL in the physical, psychological, environment, and overall domain.

CONCLUSIONS: Patients with IC had a significantly higher QOL in the physical, psychological, environment, and overall domains of the WHOQOL-BREF questionnaire compared with patients with CLTI. This underlines the importance of strategies that reduce disease progression as disease progression is associated with a decrease in QOL.

Original language	English
Pages (from-to)	285-291
Number of pages	7
Journal	Annals of Vascular Surgery
Volume	69
DOIs	https://doi.org/10.1016/j.avsg.2020.05.048
Publication status	Published - Nov 2020

Keywords

Age Factors
Aged
Aged, 80 and over
Chronic Disease
Disease Progression
Female
Humans
Intermittent Claudication/diagnosis
Ischemia/diagnosis
Male
Patient Reported Outcome Measures
Predictive Value of Tests
Quality of Life
Registries
SMOKING
WORLD-HEALTH-ORGANIZATION

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10.1016/j.avsg.2020.05.048

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Cite this

Roijers, J. P., van den Houten, M. M., Hopmans, N. J., Vriens, P. W. H. E., Willigendael, E. M., Lodder, P., de Vries, J., Teijink, J. A., & van der Laan, L. (2020). A Comparison of Quality of Life in Elderly Patients with Intermittent Claudication and Chronic Limb-Threatening Ischemia. Annals of Vascular Surgery, 69, 285-291. https://doi.org/10.1016/j.avsg.2020.05.048

@article{1b9d05542165401c911ef090ce096a5e,

title = "A Comparison of Quality of Life in Elderly Patients with Intermittent Claudication and Chronic Limb-Threatening Ischemia",

abstract = "BACKGROUND: Intermittent claudication (IC) and chronic limb-threatening ischemia (CLTI) are both associated with a decreased health status and possibly quality of life (QOL). A better understanding of the differences in QOL between patients with IC and CLTI could be of additional value in shared decision-making. The aim of this study was to compare the QOL at baseline between patients with IC and patients with CLTI.METHODS: The study population was based on 2 study cohorts, 1 cohort consisted of patients with IC (ELECT registry) and the other cohort of patients with CLTI (KOP-study). Patients with an age of ≥70 years were included. QOL at baseline was measured by the WHOQOL-BREF questionnaire. Nonresponders were excluded from data analyses. Student's t-tests and analysis of covariance (ANCOVA) analyses were used to compare QOL between the 2 groups. Outcomes of the ANCOVA analyses were expressed as estimated marginal means.RESULTS: In total, 308 patients were included, 115 patients with IC and 193 patients with CLTI. Patients with CLTI were older (median age 80 years vs. 75 years, P < 0.001) and had more comorbidities. Patients with IC had a statistically significant higher QOL regarding physical health (mean 13.7 [standard deviation (SD) 2.3] vs. 10.8 [SD 2.8], P < 0.001), psychological health (mean 15.3 [SD 2.1] vs. 14.1 [SD 2.4], P < 0.001), environment (mean 16.3 [SD 2.4] vs. 15.5 [SD 2.0], P < 0.002), and the overall domain (mean 3.5 [SD 0.7] vs. 3.1 [SD 0.9], P < 0.001). After correcting for the confounding effect of age and sex, patients with IC still had a statistically significant higher QOL in the physical, psychological, environment, and overall domain.CONCLUSIONS: Patients with IC had a significantly higher QOL in the physical, psychological, environment, and overall domains of the WHOQOL-BREF questionnaire compared with patients with CLTI. This underlines the importance of strategies that reduce disease progression as disease progression is associated with a decrease in QOL.",

keywords = "Age Factors, Aged, Aged, 80 and over, Chronic Disease, Disease Progression, Female, Humans, Intermittent Claudication/diagnosis, Ischemia/diagnosis, Male, Patient Reported Outcome Measures, Predictive Value of Tests, Quality of Life, Registries, SMOKING, WORLD-HEALTH-ORGANIZATION",

author = "Roijers, {Joost P} and {van den Houten}, {Marijn M} and Hopmans, {Niels J} and Vriens, {Patrick W H E} and Willigendael, {Edith M} and Paul Lodder and {de Vries}, Jolanda and Teijink, {Joep A} and {van der Laan}, Lijckle",

year = "2020",

month = nov,

doi = "10.1016/j.avsg.2020.05.048",

language = "English",

volume = "69",

pages = "285--291",

journal = "Annals of Vascular Surgery",

issn = "0890-5096",

publisher = "Elsevier Science",

}

TY - JOUR

T1 - A Comparison of Quality of Life in Elderly Patients with Intermittent Claudication and Chronic Limb-Threatening Ischemia

AU - Roijers, Joost P

AU - van den Houten, Marijn M

AU - Hopmans, Niels J

AU - Vriens, Patrick W H E

AU - Willigendael, Edith M

AU - Lodder, Paul

AU - de Vries, Jolanda

AU - Teijink, Joep A

AU - van der Laan, Lijckle

PY - 2020/11

Y1 - 2020/11

N2 - BACKGROUND: Intermittent claudication (IC) and chronic limb-threatening ischemia (CLTI) are both associated with a decreased health status and possibly quality of life (QOL). A better understanding of the differences in QOL between patients with IC and CLTI could be of additional value in shared decision-making. The aim of this study was to compare the QOL at baseline between patients with IC and patients with CLTI.METHODS: The study population was based on 2 study cohorts, 1 cohort consisted of patients with IC (ELECT registry) and the other cohort of patients with CLTI (KOP-study). Patients with an age of ≥70 years were included. QOL at baseline was measured by the WHOQOL-BREF questionnaire. Nonresponders were excluded from data analyses. Student's t-tests and analysis of covariance (ANCOVA) analyses were used to compare QOL between the 2 groups. Outcomes of the ANCOVA analyses were expressed as estimated marginal means.RESULTS: In total, 308 patients were included, 115 patients with IC and 193 patients with CLTI. Patients with CLTI were older (median age 80 years vs. 75 years, P < 0.001) and had more comorbidities. Patients with IC had a statistically significant higher QOL regarding physical health (mean 13.7 [standard deviation (SD) 2.3] vs. 10.8 [SD 2.8], P < 0.001), psychological health (mean 15.3 [SD 2.1] vs. 14.1 [SD 2.4], P < 0.001), environment (mean 16.3 [SD 2.4] vs. 15.5 [SD 2.0], P < 0.002), and the overall domain (mean 3.5 [SD 0.7] vs. 3.1 [SD 0.9], P < 0.001). After correcting for the confounding effect of age and sex, patients with IC still had a statistically significant higher QOL in the physical, psychological, environment, and overall domain.CONCLUSIONS: Patients with IC had a significantly higher QOL in the physical, psychological, environment, and overall domains of the WHOQOL-BREF questionnaire compared with patients with CLTI. This underlines the importance of strategies that reduce disease progression as disease progression is associated with a decrease in QOL.

AB - BACKGROUND: Intermittent claudication (IC) and chronic limb-threatening ischemia (CLTI) are both associated with a decreased health status and possibly quality of life (QOL). A better understanding of the differences in QOL between patients with IC and CLTI could be of additional value in shared decision-making. The aim of this study was to compare the QOL at baseline between patients with IC and patients with CLTI.METHODS: The study population was based on 2 study cohorts, 1 cohort consisted of patients with IC (ELECT registry) and the other cohort of patients with CLTI (KOP-study). Patients with an age of ≥70 years were included. QOL at baseline was measured by the WHOQOL-BREF questionnaire. Nonresponders were excluded from data analyses. Student's t-tests and analysis of covariance (ANCOVA) analyses were used to compare QOL between the 2 groups. Outcomes of the ANCOVA analyses were expressed as estimated marginal means.RESULTS: In total, 308 patients were included, 115 patients with IC and 193 patients with CLTI. Patients with CLTI were older (median age 80 years vs. 75 years, P < 0.001) and had more comorbidities. Patients with IC had a statistically significant higher QOL regarding physical health (mean 13.7 [standard deviation (SD) 2.3] vs. 10.8 [SD 2.8], P < 0.001), psychological health (mean 15.3 [SD 2.1] vs. 14.1 [SD 2.4], P < 0.001), environment (mean 16.3 [SD 2.4] vs. 15.5 [SD 2.0], P < 0.002), and the overall domain (mean 3.5 [SD 0.7] vs. 3.1 [SD 0.9], P < 0.001). After correcting for the confounding effect of age and sex, patients with IC still had a statistically significant higher QOL in the physical, psychological, environment, and overall domain.CONCLUSIONS: Patients with IC had a significantly higher QOL in the physical, psychological, environment, and overall domains of the WHOQOL-BREF questionnaire compared with patients with CLTI. This underlines the importance of strategies that reduce disease progression as disease progression is associated with a decrease in QOL.

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Chronic Disease

KW - Disease Progression

KW - Female

KW - Humans

KW - Intermittent Claudication/diagnosis

KW - Ischemia/diagnosis

KW - Male

KW - Patient Reported Outcome Measures

KW - Predictive Value of Tests

KW - Quality of Life

KW - Registries

KW - SMOKING

KW - WORLD-HEALTH-ORGANIZATION

U2 - 10.1016/j.avsg.2020.05.048

DO - 10.1016/j.avsg.2020.05.048

M3 - Article

C2 - 32502674

SN - 0890-5096

VL - 69

SP - 285

EP - 291

JO - Annals of Vascular Surgery

JF - Annals of Vascular Surgery

ER -