A Comparison of Health Status and Quality of Life in Patients with Intermittent Claudication

J P Roijers; M M L van den Houten; C J Hopmans; P W H E Vriens; E M Willigendael; P Lodder; J de Vries; J A W Teijink; L van der Laan

doi:10.1016/j.avsg.2021.06.040

A Comparison of Health Status and Quality of Life in Patients with Intermittent Claudication

J P Roijers^*, M M L van den Houten, C J Hopmans, P W H E Vriens, E M Willigendael, P Lodder, J de Vries, J A W Teijink, L van der Laan

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: Patient reported outcome measures (PROMs) such as health status (HS) and quality of life (QOL) are frequently used interchangeably while they represent different outcomes. Whether a discrepancy exists in patients with intermittent claudication (IC) in changes over time between HS and QOL is unclear. This study aimed to investigate the strength and the direction of the association between HS and QOL over time in patients with IC that underwent supervised exercise therapy (SET).

MATERIAL AND METHODS: Patients were part of the ELECT multi-center prospective cohort study. One goal of this study was to obtain data on HS and QOL at different time intervals of patients with IC that underwent SET. HS (VascuQOL-6) and QOL (WHOQOL-BREF) were completed at baseline, 3 months, and 6 months follow up. Pearson's correlation coefficients and the associated common variances (R2) were calculated to measure the strength and the direction of the association between HS and QOL in changes between baseline and follow-up moments.

RESULTS: In total, 177 patients were included in data analyses. Only changes in physical QOL and overall QOL had a small correlation with changes over time in HS, at both 3- and 6 months follow up (respectively R2=.14; P < 0.001 and R2 = 0.12; P < 0.001 for physical QOL and R2 = 0.18; P < 0.001 and R2 = 0.13; P < 0.001 for overall QOL).

CONCLUSIONS: This study showed that HS and QOL provide different outcomes in patients with IC that underwent SET. Future studies should be aware of these differences before PROMs are being incorporated as an outcome measure in clinical studies.

Original language	English
Pages (from-to)	302-309
Number of pages	8
Journal	Annals of Vascular Surgery
Volume	78
DOIs	https://doi.org/10.1016/j.avsg.2021.06.040
Publication status	Published - Jan 2022

Keywords

Aged
Exercise Therapy
Female
Health Status
Humans
Intermittent Claudication/diagnosis
Male
Middle Aged
Netherlands
Patient Reported Outcome Measures
Prospective Studies
Quality of Life
Time Factors
Treatment Outcome

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10.1016/j.avsg.2021.06.040

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Cite this

@article{96100b4d448d4a9490e94cf05aecbfe6,

title = "A Comparison of Health Status and Quality of Life in Patients with Intermittent Claudication",

abstract = "BACKGROUND: Patient reported outcome measures (PROMs) such as health status (HS) and quality of life (QOL) are frequently used interchangeably while they represent different outcomes. Whether a discrepancy exists in patients with intermittent claudication (IC) in changes over time between HS and QOL is unclear. This study aimed to investigate the strength and the direction of the association between HS and QOL over time in patients with IC that underwent supervised exercise therapy (SET).MATERIAL AND METHODS: Patients were part of the ELECT multi-center prospective cohort study. One goal of this study was to obtain data on HS and QOL at different time intervals of patients with IC that underwent SET. HS (VascuQOL-6) and QOL (WHOQOL-BREF) were completed at baseline, 3 months, and 6 months follow up. Pearson's correlation coefficients and the associated common variances (R2) were calculated to measure the strength and the direction of the association between HS and QOL in changes between baseline and follow-up moments.RESULTS: In total, 177 patients were included in data analyses. Only changes in physical QOL and overall QOL had a small correlation with changes over time in HS, at both 3- and 6 months follow up (respectively R2=.14; P < 0.001 and R2 = 0.12; P < 0.001 for physical QOL and R2 = 0.18; P < 0.001 and R2 = 0.13; P < 0.001 for overall QOL).CONCLUSIONS: This study showed that HS and QOL provide different outcomes in patients with IC that underwent SET. Future studies should be aware of these differences before PROMs are being incorporated as an outcome measure in clinical studies.",

keywords = "Aged, Exercise Therapy, Female, Health Status, Humans, Intermittent Claudication/diagnosis, Male, Middle Aged, Netherlands, Patient Reported Outcome Measures, Prospective Studies, Quality of Life, Time Factors, Treatment Outcome",

author = "Roijers, {J P} and {van den Houten}, {M M L} and Hopmans, {C J} and Vriens, {P W H E} and Willigendael, {E M} and P Lodder and {de Vries}, J and Teijink, {J A W} and {van der Laan}, L",

year = "2022",

month = jan,

doi = "10.1016/j.avsg.2021.06.040",

language = "English",

volume = "78",

pages = "302--309",

journal = "Annals of Vascular Surgery",

issn = "0890-5096",

publisher = "Elsevier Science",

}

TY - JOUR

T1 - A Comparison of Health Status and Quality of Life in Patients with Intermittent Claudication

AU - Roijers, J P

AU - van den Houten, M M L

AU - Hopmans, C J

AU - Vriens, P W H E

AU - Willigendael, E M

AU - Lodder, P

AU - de Vries, J

AU - Teijink, J A W

AU - van der Laan, L

PY - 2022/1

Y1 - 2022/1

N2 - BACKGROUND: Patient reported outcome measures (PROMs) such as health status (HS) and quality of life (QOL) are frequently used interchangeably while they represent different outcomes. Whether a discrepancy exists in patients with intermittent claudication (IC) in changes over time between HS and QOL is unclear. This study aimed to investigate the strength and the direction of the association between HS and QOL over time in patients with IC that underwent supervised exercise therapy (SET).MATERIAL AND METHODS: Patients were part of the ELECT multi-center prospective cohort study. One goal of this study was to obtain data on HS and QOL at different time intervals of patients with IC that underwent SET. HS (VascuQOL-6) and QOL (WHOQOL-BREF) were completed at baseline, 3 months, and 6 months follow up. Pearson's correlation coefficients and the associated common variances (R2) were calculated to measure the strength and the direction of the association between HS and QOL in changes between baseline and follow-up moments.RESULTS: In total, 177 patients were included in data analyses. Only changes in physical QOL and overall QOL had a small correlation with changes over time in HS, at both 3- and 6 months follow up (respectively R2=.14; P < 0.001 and R2 = 0.12; P < 0.001 for physical QOL and R2 = 0.18; P < 0.001 and R2 = 0.13; P < 0.001 for overall QOL).CONCLUSIONS: This study showed that HS and QOL provide different outcomes in patients with IC that underwent SET. Future studies should be aware of these differences before PROMs are being incorporated as an outcome measure in clinical studies.

AB - BACKGROUND: Patient reported outcome measures (PROMs) such as health status (HS) and quality of life (QOL) are frequently used interchangeably while they represent different outcomes. Whether a discrepancy exists in patients with intermittent claudication (IC) in changes over time between HS and QOL is unclear. This study aimed to investigate the strength and the direction of the association between HS and QOL over time in patients with IC that underwent supervised exercise therapy (SET).MATERIAL AND METHODS: Patients were part of the ELECT multi-center prospective cohort study. One goal of this study was to obtain data on HS and QOL at different time intervals of patients with IC that underwent SET. HS (VascuQOL-6) and QOL (WHOQOL-BREF) were completed at baseline, 3 months, and 6 months follow up. Pearson's correlation coefficients and the associated common variances (R2) were calculated to measure the strength and the direction of the association between HS and QOL in changes between baseline and follow-up moments.RESULTS: In total, 177 patients were included in data analyses. Only changes in physical QOL and overall QOL had a small correlation with changes over time in HS, at both 3- and 6 months follow up (respectively R2=.14; P < 0.001 and R2 = 0.12; P < 0.001 for physical QOL and R2 = 0.18; P < 0.001 and R2 = 0.13; P < 0.001 for overall QOL).CONCLUSIONS: This study showed that HS and QOL provide different outcomes in patients with IC that underwent SET. Future studies should be aware of these differences before PROMs are being incorporated as an outcome measure in clinical studies.

KW - Aged

KW - Exercise Therapy

KW - Female

KW - Health Status

KW - Humans

KW - Intermittent Claudication/diagnosis

KW - Male

KW - Middle Aged

KW - Netherlands

KW - Patient Reported Outcome Measures

KW - Prospective Studies

KW - Quality of Life

KW - Time Factors

KW - Treatment Outcome

U2 - 10.1016/j.avsg.2021.06.040

DO - 10.1016/j.avsg.2021.06.040

M3 - Article

C2 - 34543716

SN - 0890-5096

VL - 78

SP - 302

EP - 309

JO - Annals of Vascular Surgery

JF - Annals of Vascular Surgery

ER -