A comparison of dicarbonyl stress and advanced glycation endproducts in lifelong endurance athletes vs. sedentary controls

Martijn F. H. Maessen; Casper G. Schalkwijk; Rebecca J. H. M. Verheggen; Vincent L. Aengevaeren; Maria T. E. Hopman; Thijs M. H. Eijsvogels

doi:10.1016/j.jsams.2017.03.011

A comparison of dicarbonyl stress and advanced glycation endproducts in lifelong endurance athletes vs. sedentary controls

Martijn F. H. Maessen, Casper G. Schalkwijk, Rebecca J. H. M. Verheggen, Vincent L. Aengevaeren, Maria T. E. Hopman, Thijs M. H. Eijsvogels^*

^*Corresponding author for this work

Interne Geneeskunde

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Web of Science)

Abstract

Objectives: Dicarbonyl stress and high concentrations of advanced glycation endproducts (AGEs) relate to an elevated risk for cardiovascular diseases (CVD). Exercise training lowers the risk for future CVD. We tested the hypothesis that lifelong endurance athletes have lower dicarbonyl stress and AGEs compared to sedentary controls and that these differences relate to a better cardiovascular health profile.

Design: Cross-sectional study.

Methods: We included 18 lifelong endurance athletes (ATH, 61 7 years) and 18 sedentary controls (SED, 58 +/- 7 years) and measured circulating glyoxal (GO), methylglyoxal (MGO) and 3-deoxyglucosone (3DG) as markers of dicarbonyl stress. Furthermore, we measured serum levels of protein bound AGEs N-epsilon-(carboxymethyl)lysine (CML), N-epsilon-(carboxyethyplysine (CEL), methylglyoxal-derived hydroimidazolone-1 (MG-H1), and pentosidine. Additionally, we measured cardiorespiratory fitness (VO(2)peak) and cardiovascular health markers.

Results: ATH had lower concentrations of MGO (196 [180-246] vs. 242 [207-292] nmol/mmol lysine, p = 0.043) and 3DG (927 [868-972] vs. 1061 [982-1114] nmol/mmol lysine, p <0.01), but no GO compared to SED. ATH demonstrated higher concentrations CML and CEL compared to SED. Pentosidine did not differ across groups and MG-H1 was significantly lower in ATH compared to SED. Concentrations of MGO en 3DG were inversely correlated with cardiovascular health markers, whereas CML and CEL were positively correlated with VO(2)peak and cardiovascular health markers.

Conclusion: Lifelong exercise training relates to lower dicarbonyl stress (MGO and 3DG) and the AGE MG-H1. The underlying mechanism and (clinical) relevance of higher CML and CEL concentrations among lifelong athletes warrants future research, since it conflicts with the idea that higher AGE concentrations relate to poor cardiovascular health outcomes. (C) 2017 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	921-926
Number of pages	6
Journal	Journal of Science and Medicine in Sport
Volume	20
Issue number	10
DOIs	https://doi.org/10.1016/j.jsams.2017.03.011
Publication status	Published - Oct 2017

Keywords

Oxidative stress
Cardiovascular disease
Physical activity
Exercise physiology
END-PRODUCTS
CARDIOVASCULAR EVENTS
ARTERIAL STIFFNESS
CARBOXYMETHYL-LYSINE
INSULIN-RESISTANCE
OXIDATIVE STRESS
EXERCISE
METHYLGLYOXAL
MECHANISMS
INDIVIDUALS

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10.1016/j.jsams.2017.03.011

Cite this

@article{60816cfa93f94327993385030f1c4f15,

title = "A comparison of dicarbonyl stress and advanced glycation endproducts in lifelong endurance athletes vs. sedentary controls",

abstract = "Objectives: Dicarbonyl stress and high concentrations of advanced glycation endproducts (AGEs) relate to an elevated risk for cardiovascular diseases (CVD). Exercise training lowers the risk for future CVD. We tested the hypothesis that lifelong endurance athletes have lower dicarbonyl stress and AGEs compared to sedentary controls and that these differences relate to a better cardiovascular health profile.Design: Cross-sectional study.Methods: We included 18 lifelong endurance athletes (ATH, 61 7 years) and 18 sedentary controls (SED, 58 +/- 7 years) and measured circulating glyoxal (GO), methylglyoxal (MGO) and 3-deoxyglucosone (3DG) as markers of dicarbonyl stress. Furthermore, we measured serum levels of protein bound AGEs N-epsilon-(carboxymethyl)lysine (CML), N-epsilon-(carboxyethyplysine (CEL), methylglyoxal-derived hydroimidazolone-1 (MG-H1), and pentosidine. Additionally, we measured cardiorespiratory fitness (VO(2)peak) and cardiovascular health markers.Results: ATH had lower concentrations of MGO (196 [180-246] vs. 242 [207-292] nmol/mmol lysine, p = 0.043) and 3DG (927 [868-972] vs. 1061 [982-1114] nmol/mmol lysine, p <0.01), but no GO compared to SED. ATH demonstrated higher concentrations CML and CEL compared to SED. Pentosidine did not differ across groups and MG-H1 was significantly lower in ATH compared to SED. Concentrations of MGO en 3DG were inversely correlated with cardiovascular health markers, whereas CML and CEL were positively correlated with VO(2)peak and cardiovascular health markers.Conclusion: Lifelong exercise training relates to lower dicarbonyl stress (MGO and 3DG) and the AGE MG-H1. The underlying mechanism and (clinical) relevance of higher CML and CEL concentrations among lifelong athletes warrants future research, since it conflicts with the idea that higher AGE concentrations relate to poor cardiovascular health outcomes. (C) 2017 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.",

keywords = "Oxidative stress, Cardiovascular disease, Physical activity, Exercise physiology, END-PRODUCTS, CARDIOVASCULAR EVENTS, ARTERIAL STIFFNESS, CARBOXYMETHYL-LYSINE, INSULIN-RESISTANCE, OXIDATIVE STRESS, EXERCISE, METHYLGLYOXAL, MECHANISMS, INDIVIDUALS",

author = "Maessen, {Martijn F. H.} and Schalkwijk, {Casper G.} and Verheggen, {Rebecca J. H. M.} and Aengevaeren, {Vincent L.} and Hopman, {Maria T. E.} and Eijsvogels, {Thijs M. H.}",

year = "2017",

month = oct,

doi = "10.1016/j.jsams.2017.03.011",

language = "English",

volume = "20",

pages = "921--926",

journal = "Journal of Science and Medicine in Sport",

issn = "1440-2440",

publisher = "ELSEVIER SCI LTD",

number = "10",

}

A comparison of dicarbonyl stress and advanced glycation endproducts in lifelong endurance athletes vs. sedentary controls. / Maessen, Martijn F. H.; Schalkwijk, Casper G.; Verheggen, Rebecca J. H. M. et al.

In: Journal of Science and Medicine in Sport, Vol. 20, No. 10, 10.2017, p. 921-926.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A comparison of dicarbonyl stress and advanced glycation endproducts in lifelong endurance athletes vs. sedentary controls

AU - Maessen, Martijn F. H.

AU - Schalkwijk, Casper G.

AU - Verheggen, Rebecca J. H. M.

AU - Aengevaeren, Vincent L.

AU - Hopman, Maria T. E.

AU - Eijsvogels, Thijs M. H.

PY - 2017/10

Y1 - 2017/10

N2 - Objectives: Dicarbonyl stress and high concentrations of advanced glycation endproducts (AGEs) relate to an elevated risk for cardiovascular diseases (CVD). Exercise training lowers the risk for future CVD. We tested the hypothesis that lifelong endurance athletes have lower dicarbonyl stress and AGEs compared to sedentary controls and that these differences relate to a better cardiovascular health profile.Design: Cross-sectional study.Methods: We included 18 lifelong endurance athletes (ATH, 61 7 years) and 18 sedentary controls (SED, 58 +/- 7 years) and measured circulating glyoxal (GO), methylglyoxal (MGO) and 3-deoxyglucosone (3DG) as markers of dicarbonyl stress. Furthermore, we measured serum levels of protein bound AGEs N-epsilon-(carboxymethyl)lysine (CML), N-epsilon-(carboxyethyplysine (CEL), methylglyoxal-derived hydroimidazolone-1 (MG-H1), and pentosidine. Additionally, we measured cardiorespiratory fitness (VO(2)peak) and cardiovascular health markers.Results: ATH had lower concentrations of MGO (196 [180-246] vs. 242 [207-292] nmol/mmol lysine, p = 0.043) and 3DG (927 [868-972] vs. 1061 [982-1114] nmol/mmol lysine, p <0.01), but no GO compared to SED. ATH demonstrated higher concentrations CML and CEL compared to SED. Pentosidine did not differ across groups and MG-H1 was significantly lower in ATH compared to SED. Concentrations of MGO en 3DG were inversely correlated with cardiovascular health markers, whereas CML and CEL were positively correlated with VO(2)peak and cardiovascular health markers.Conclusion: Lifelong exercise training relates to lower dicarbonyl stress (MGO and 3DG) and the AGE MG-H1. The underlying mechanism and (clinical) relevance of higher CML and CEL concentrations among lifelong athletes warrants future research, since it conflicts with the idea that higher AGE concentrations relate to poor cardiovascular health outcomes. (C) 2017 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

AB - Objectives: Dicarbonyl stress and high concentrations of advanced glycation endproducts (AGEs) relate to an elevated risk for cardiovascular diseases (CVD). Exercise training lowers the risk for future CVD. We tested the hypothesis that lifelong endurance athletes have lower dicarbonyl stress and AGEs compared to sedentary controls and that these differences relate to a better cardiovascular health profile.Design: Cross-sectional study.Methods: We included 18 lifelong endurance athletes (ATH, 61 7 years) and 18 sedentary controls (SED, 58 +/- 7 years) and measured circulating glyoxal (GO), methylglyoxal (MGO) and 3-deoxyglucosone (3DG) as markers of dicarbonyl stress. Furthermore, we measured serum levels of protein bound AGEs N-epsilon-(carboxymethyl)lysine (CML), N-epsilon-(carboxyethyplysine (CEL), methylglyoxal-derived hydroimidazolone-1 (MG-H1), and pentosidine. Additionally, we measured cardiorespiratory fitness (VO(2)peak) and cardiovascular health markers.Results: ATH had lower concentrations of MGO (196 [180-246] vs. 242 [207-292] nmol/mmol lysine, p = 0.043) and 3DG (927 [868-972] vs. 1061 [982-1114] nmol/mmol lysine, p <0.01), but no GO compared to SED. ATH demonstrated higher concentrations CML and CEL compared to SED. Pentosidine did not differ across groups and MG-H1 was significantly lower in ATH compared to SED. Concentrations of MGO en 3DG were inversely correlated with cardiovascular health markers, whereas CML and CEL were positively correlated with VO(2)peak and cardiovascular health markers.Conclusion: Lifelong exercise training relates to lower dicarbonyl stress (MGO and 3DG) and the AGE MG-H1. The underlying mechanism and (clinical) relevance of higher CML and CEL concentrations among lifelong athletes warrants future research, since it conflicts with the idea that higher AGE concentrations relate to poor cardiovascular health outcomes. (C) 2017 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

KW - Oxidative stress

KW - Cardiovascular disease

KW - Physical activity

KW - Exercise physiology

KW - END-PRODUCTS

KW - CARDIOVASCULAR EVENTS

KW - ARTERIAL STIFFNESS

KW - CARBOXYMETHYL-LYSINE

KW - INSULIN-RESISTANCE

KW - OXIDATIVE STRESS

KW - EXERCISE

KW - METHYLGLYOXAL

KW - MECHANISMS

KW - INDIVIDUALS

U2 - 10.1016/j.jsams.2017.03.011

DO - 10.1016/j.jsams.2017.03.011

M3 - Article

C2 - 28416154

SN - 1440-2440

VL - 20

SP - 921

EP - 926

JO - Journal of Science and Medicine in Sport

JF - Journal of Science and Medicine in Sport

IS - 10

ER -