A Combination of Transcriptomics and Metabolomics Uncovers Enhanced Bile Acid Biosynthesis in HepG2 Cells Expressing CCAAT/Enhancer-Binding Protein beta (C/EBP beta), Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha), and Constitutive Androstane Receptor (CAR)

Marina Blazquez; Aitor Carretero; James K. Ellis; Toby J. Athersuch; Rachel Cavill; Timothy M. D. Ebbels; Hector C. Keun; Jose V. Castell; Agustin Lahoz; Roque Bort

doi:10.1021/pr400085n

A Combination of Transcriptomics and Metabolomics Uncovers Enhanced Bile Acid Biosynthesis in HepG2 Cells Expressing CCAAT/Enhancer-Binding Protein beta (C/EBP beta), Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha), and Constitutive Androstane Receptor (CAR)

Marina Blazquez, Aitor Carretero, James K. Ellis, Toby J. Athersuch, Rachel Cavill, Timothy M. D. Ebbels, Hector C. Keun, Jose V. Castell, Agustin Lahoz, Roque Bort^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	2732-2741
Journal	Journal of Proteome Research
Volume	12
Issue number	6
DOIs	https://doi.org/10.1021/pr400085n
Publication status	Published - Jun 2013

Keywords

HepG2
bile acids
hepatic model
chenodeoxycholic acid
CDCA
C/EBP
HNF4
CAR
NMR spectroscopy
metabolomics
metabonomics

Access to Document

10.1021/pr400085n

Cite this

Blazquez, M., Carretero, A., Ellis, J. K., Athersuch, T. J., Cavill, R., Ebbels, T. M. D., Keun, H. C., Castell, J. V., Lahoz, A., & Bort, R. (2013). A Combination of Transcriptomics and Metabolomics Uncovers Enhanced Bile Acid Biosynthesis in HepG2 Cells Expressing CCAAT/Enhancer-Binding Protein beta (C/EBP beta), Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha), and Constitutive Androstane Receptor (CAR). Journal of Proteome Research, 12(6), 2732-2741. https://doi.org/10.1021/pr400085n

Blazquez, Marina ; Carretero, Aitor ; Ellis, James K. ; Athersuch, Toby J. ; Cavill, Rachel ; Ebbels, Timothy M. D. ; Keun, Hector C. ; Castell, Jose V. ; Lahoz, Agustin ; Bort, Roque. / A Combination of Transcriptomics and Metabolomics Uncovers Enhanced Bile Acid Biosynthesis in HepG2 Cells Expressing CCAAT/Enhancer-Binding Protein beta (C/EBP beta), Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha), and Constitutive Androstane Receptor (CAR). In: Journal of Proteome Research. 2013 ; Vol. 12, No. 6. pp. 2732-2741.

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title = "A Combination of Transcriptomics and Metabolomics Uncovers Enhanced Bile Acid Biosynthesis in HepG2 Cells Expressing CCAAT/Enhancer-Binding Protein beta (C/EBP beta), Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha), and Constitutive Androstane Receptor (CAR)",

keywords = "HepG2, bile acids, hepatic model, chenodeoxycholic acid, CDCA, C/EBP, HNF4, CAR, NMR spectroscopy, metabolomics, metabonomics",

author = "Marina Blazquez and Aitor Carretero and Ellis, {James K.} and Athersuch, {Toby J.} and Rachel Cavill and Ebbels, {Timothy M. D.} and Keun, {Hector C.} and Castell, {Jose V.} and Agustin Lahoz and Roque Bort",

year = "2013",

month = jun,

doi = "10.1021/pr400085n",

language = "English",

volume = "12",

pages = "2732--2741",

journal = "Journal of Proteome Research",

issn = "1535-3893",

publisher = "American Chemical Society",

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Blazquez, M, Carretero, A, Ellis, JK, Athersuch, TJ, Cavill, R, Ebbels, TMD, Keun, HC, Castell, JV, Lahoz, A & Bort, R 2013, 'A Combination of Transcriptomics and Metabolomics Uncovers Enhanced Bile Acid Biosynthesis in HepG2 Cells Expressing CCAAT/Enhancer-Binding Protein beta (C/EBP beta), Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha), and Constitutive Androstane Receptor (CAR)', Journal of Proteome Research, vol. 12, no. 6, pp. 2732-2741. https://doi.org/10.1021/pr400085n

A Combination of Transcriptomics and Metabolomics Uncovers Enhanced Bile Acid Biosynthesis in HepG2 Cells Expressing CCAAT/Enhancer-Binding Protein beta (C/EBP beta), Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha), and Constitutive Androstane Receptor (CAR). / Blazquez, Marina; Carretero, Aitor; Ellis, James K.; Athersuch, Toby J.; Cavill, Rachel; Ebbels, Timothy M. D.; Keun, Hector C.; Castell, Jose V.; Lahoz, Agustin; Bort, Roque.

In: Journal of Proteome Research, Vol. 12, No. 6, 06.2013, p. 2732-2741.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A Combination of Transcriptomics and Metabolomics Uncovers Enhanced Bile Acid Biosynthesis in HepG2 Cells Expressing CCAAT/Enhancer-Binding Protein beta (C/EBP beta), Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha), and Constitutive Androstane Receptor (CAR)

AU - Blazquez, Marina

AU - Carretero, Aitor

AU - Ellis, James K.

AU - Athersuch, Toby J.

AU - Cavill, Rachel

AU - Ebbels, Timothy M. D.

AU - Keun, Hector C.

AU - Castell, Jose V.

AU - Lahoz, Agustin

AU - Bort, Roque

PY - 2013/6

Y1 - 2013/6

KW - HepG2

KW - bile acids

KW - hepatic model

KW - chenodeoxycholic acid

KW - CDCA

KW - C/EBP

KW - HNF4

KW - CAR

KW - NMR spectroscopy

KW - metabolomics

KW - metabonomics

U2 - 10.1021/pr400085n

DO - 10.1021/pr400085n

M3 - Article

C2 - 23641669

VL - 12

SP - 2732

EP - 2741

JO - Journal of Proteome Research

JF - Journal of Proteome Research

SN - 1535-3893

IS - 6

ER -

Blazquez M, Carretero A, Ellis JK, Athersuch TJ, Cavill R, Ebbels TMD et al. A Combination of Transcriptomics and Metabolomics Uncovers Enhanced Bile Acid Biosynthesis in HepG2 Cells Expressing CCAAT/Enhancer-Binding Protein beta (C/EBP beta), Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha), and Constitutive Androstane Receptor (CAR). Journal of Proteome Research. 2013 Jun;12(6):2732-2741. https://doi.org/10.1021/pr400085n