A Combination of Transcriptomics and Metabolomics Uncovers Enhanced Bile Acid Biosynthesis in HepG2 Cells Expressing CCAAT/Enhancer-Binding Protein beta (C/EBP beta), Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha), and Constitutive Androstane Receptor (CAR)

Marina Blazquez, Aitor Carretero, James K. Ellis, Toby J. Athersuch, Rachel Cavill, Timothy M. D. Ebbels, Hector C. Keun, Jose V. Castell, Agustin Lahoz, Roque Bort

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)2732-2741
JournalJournal of Proteome Research
Volume12
Issue number6
DOIs
Publication statusPublished - Jun 2013

Keywords

  • HepG2
  • bile acids
  • hepatic model
  • chenodeoxycholic acid
  • CDCA
  • C/EBP
  • HNF4
  • CAR
  • NMR spectroscopy
  • metabolomics
  • metabonomics

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