A Combination of Tamarindus indica seeds and Curcuma longa Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity

Posani Sriruivas Rao, Yendluri Sita Ramanjaneyulu, Victor R. Prisk, Leon J. Schurgers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Web of Science)


Background: Knee joint pain is the most common reason for physical disability which associates with age. TamaFlex (TM) (NXT15906F6) is a synergistic anti-inflammatory formulation which contains ethanol/aqueous extracts of Tamarindus indica seeds and ethanol extract of Curcuma longa rhizome.

Methods: In a 90-day randomized, double-blind, placebo-controlled study, we evaluated efficacy of NXT15906F6 in relieving pain and improving joint function in non-arthritic adults. Ninety non-arthritic subjects who experienced knee pain and joint discomfort following a six-minute walk test (SMWT) and Stair climb test (SCT) participated in the present trial. Subjects received either 250 mg (n=30) or 400 mg (n=30) of NXT15906F6 or matched placebo (PL: n=30) daily for 90 days. Improvement from baseline six-minute walk distance (SMWD) in NXT15906F6 groups, compared with placebo (PL) was the primary outcome of the study.

Results: At post-intervention, subjects in NXT15906F6-250 (p

Conclusion: NXT15906F6 provided substantial relief from knee pain after physical activity and improved joint function in non-arthritic adults. Study participants did not show any major adverse events, and they tolerated well this novel herbal formulation.

Original languageEnglish
Pages (from-to)845-853
Number of pages9
JournalInternational Journal of Medical Sciences
Issue number6
Publication statusPublished - 2019


  • Knee joint pain
  • Musculoskeletal function
  • NXT15906F6
  • Six-minute walk test
  • HIP
  • CARE

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