Abstract
Background: Knee joint pain is the most common reason for physical disability which associates with age. TamaFlex (TM) (NXT15906F6) is a synergistic anti-inflammatory formulation which contains ethanol/aqueous extracts of Tamarindus indica seeds and ethanol extract of Curcuma longa rhizome.
Methods: In a 90-day randomized, double-blind, placebo-controlled study, we evaluated efficacy of NXT15906F6 in relieving pain and improving joint function in non-arthritic adults. Ninety non-arthritic subjects who experienced knee pain and joint discomfort following a six-minute walk test (SMWT) and Stair climb test (SCT) participated in the present trial. Subjects received either 250 mg (n=30) or 400 mg (n=30) of NXT15906F6 or matched placebo (PL: n=30) daily for 90 days. Improvement from baseline six-minute walk distance (SMWD) in NXT15906F6 groups, compared with placebo (PL) was the primary outcome of the study.
Results: At post-intervention, subjects in NXT15906F6-250 (p
Conclusion: NXT15906F6 provided substantial relief from knee pain after physical activity and improved joint function in non-arthritic adults. Study participants did not show any major adverse events, and they tolerated well this novel herbal formulation.
Original language | English |
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Pages (from-to) | 845-853 |
Number of pages | 9 |
Journal | International Journal of Medical Sciences |
Volume | 16 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2019 |
Keywords
- Knee joint pain
- Musculoskeletal function
- NXT15906F6
- Six-minute walk test
- OLDER-ADULTS
- OSTEOARTHRITIS
- COMMUNITY
- HIP
- EXERCISE
- VALIDATION
- DISABILITY
- EFFICACY
- CARE