Abstract
Introduction Reliable data on the incidence rates for young-onset dementia (YOD) are lacking, but are necessary for research on disease etiology and to raise awareness among health care professionals. Methods We performed a systematic review and meta-analysis on population-based studies on the incidence of YOD, published between January 1, 1990 and February 1, 2022, according to Meta-analyses of Observational Studies in Epidemiology (MOOSE) guidelines. Data were analyzed using random-effects meta-analyses. Results were age-standardized, and heterogeneity was assessed by subgroup analyses and meta-regression. Results Sixty-one articles were included. Global age-standardized incidence rates increased from 0.17/100,000 in age 30 to 34 years, to 5.14/100,000 in age 60 to 64 years, giving a global total age-standardized incidence rate of 11 per 100,000 in age 30 to 64. This corresponds to 370,000 new YOD cases annually worldwide. Heterogeneity was high and meta-regression showed geographic location significantly influenced this heterogeneity. Discussion This meta-analysis shows the current best estimate of YOD incidence. New prospective cohort studies are needed.
Original language | English |
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Pages (from-to) | 831-843 |
Number of pages | 13 |
Journal | Alzheimer's & Dementia |
Volume | 19 |
Issue number | 3 |
Early online date | 17 Jun 2022 |
DOIs | |
Publication status | Published - Mar 2023 |
Keywords
- incidence
- meta-analysis
- worldwide
- young-onset dementia
- REPORTED SLEEP DISTURBANCE
- ALZHEIMERS-DISEASE
- PRESENILE-DEMENTIA
- INCIDENCE RATES
- RISK
- POPULATION
- PREVALENCE
- TIME
- TRENDS
- EPIDEMIOLOGY