Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial

Inez Trouwborst; Anouk Gijbels; Kelly M. Jardon; Els Siebelink; Gabby B. Hul; Lisa Wanders; Balázs Erdos; Szabolcs Péter; Cécile M. Singh-Povel; Johan de Vogel-van den Bosch; Michiel E. Adriaens; Ilja C.W. Arts; Dick H.J. Thijssen; Edith J.M. Feskens; Gijs H. Goossens; Lydia A. Afman; Ellen E. Blaak

doi:10.1016/j.cmet.2022.12.002

Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial

Inez Trouwborst, Anouk Gijbels, Kelly M. Jardon, Els Siebelink, Gabby B. Hul, Lisa Wanders, Balázs Erdos, Szabolcs Péter, Cécile M. Singh-Povel, Johan de Vogel-van den Bosch, Michiel E. Adriaens, Ilja C.W. Arts, Dick H.J. Thijssen, Edith J.M. Feskens, Gijs H. Goossens, Lydia A. Afman, Ellen E. Blaak^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Summary Precision nutrition based on metabolic phenotype may increase the effectiveness of interventions. In this proof-of-concept study, we investigated the effect of modulating dietary macronutrient composition according to muscle insulin-resistant (MIR) or liver insulin-resistant (LIR) phenotypes on cardiometabolic health. Women and men with MIR or LIR (n = 242, body mass index [BMI] 25–40 kg/m2, 40–75 years) were randomized to phenotype diet (PhenoDiet) group A or B and followed a 12-week high-monounsaturated fatty acid (HMUFA) diet or low-fat, high-protein, and high-fiber diet (LFHP) (PhenoDiet group A, MIR/HMUFA and LIR/LFHP; PhenoDiet group B, MIR/LFHP and LIR/HMUFA). PhenoDiet group B showed no significant improvements in the primary outcome disposition index, but greater improvements in insulin sensitivity, glucose homeostasis, serum triacylglycerol, and C-reactive protein compared with PhenoDiet group A were observed. We demonstrate that modulating macronutrient composition within the dietary guidelines based on tissue-specific insulin resistance (IR) phenotype enhances cardiometabolic health improvements. Clinicaltrials.gov registration: NCT03708419, CCMO registration NL63768.068.17.

Original language	English
Pages (from-to)	71-83.e5
Number of pages	19
Journal	Cell Metabolism
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2022.12.002
Publication status	Published - 3 Jan 2023

Keywords

precision nutrition
dietary intervention trial
tissue-specific insulin resistance
metabotyping
glucose homeostasis
cardiometabolic health

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Cite this

Trouwborst, I., Gijbels, A., Jardon, K. M., Siebelink, E., Hul, G. B., Wanders, L., Erdos, B., Péter, S., Singh-Povel, C. M., de Vogel-van den Bosch, J., Adriaens, M. E., Arts, I. C. W., Thijssen, D. H. J., Feskens, E. J. M., Goossens, G. H., Afman, L. A., & Blaak, E. E. (2023). Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial. Cell Metabolism, 35(1), 71-83.e5. https://doi.org/10.1016/j.cmet.2022.12.002

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title = "Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial",

abstract = "Summary Precision nutrition based on metabolic phenotype may increase the effectiveness of interventions. In this proof-of-concept study, we investigated the effect of modulating dietary macronutrient composition according to muscle insulin-resistant (MIR) or liver insulin-resistant (LIR) phenotypes on cardiometabolic health. Women and men with MIR or LIR (n = 242, body mass index [BMI] 25–40 kg/m2, 40–75 years) were randomized to phenotype diet (PhenoDiet) group A or B and followed a 12-week high-monounsaturated fatty acid (HMUFA) diet or low-fat, high-protein, and high-fiber diet (LFHP) (PhenoDiet group A, MIR/HMUFA and LIR/LFHP; PhenoDiet group B, MIR/LFHP and LIR/HMUFA). PhenoDiet group B showed no significant improvements in the primary outcome disposition index, but greater improvements in insulin sensitivity, glucose homeostasis, serum triacylglycerol, and C-reactive protein compared with PhenoDiet group A were observed. We demonstrate that modulating macronutrient composition within the dietary guidelines based on tissue-specific insulin resistance (IR) phenotype enhances cardiometabolic health improvements. Clinicaltrials.gov registration: NCT03708419, CCMO registration NL63768.068.17.",

keywords = "precision nutrition, dietary intervention trial, tissue-specific insulin resistance, metabotyping, glucose homeostasis, cardiometabolic health",

author = "Inez Trouwborst and Anouk Gijbels and Jardon, {Kelly M.} and Els Siebelink and Hul, {Gabby B.} and Lisa Wanders and Bal{\'a}zs Erdos and Szabolcs P{\'e}ter and Singh-Povel, {C{\'e}cile M.} and {de Vogel-van den Bosch}, Johan and Adriaens, {Michiel E.} and Arts, {Ilja C.W.} and Thijssen, {Dick H.J.} and Feskens, {Edith J.M.} and Goossens, {Gijs H.} and Afman, {Lydia A.} and Blaak, {Ellen E.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2023",

month = jan,

day = "3",

doi = "10.1016/j.cmet.2022.12.002",

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Trouwborst, I, Gijbels, A, Jardon, KM, Siebelink, E, Hul, GB, Wanders, L, Erdos, B, Péter, S, Singh-Povel, CM, de Vogel-van den Bosch, J, Adriaens, ME , Arts, ICW, Thijssen, DHJ, Feskens, EJM, Goossens, GH, Afman, LA & Blaak, EE 2023, 'Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial', Cell Metabolism, vol. 35, no. 1, pp. 71-83.e5. https://doi.org/10.1016/j.cmet.2022.12.002

TY - JOUR

T1 - Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial

AU - Trouwborst, Inez

AU - Gijbels, Anouk

AU - Jardon, Kelly M.

AU - Siebelink, Els

AU - Hul, Gabby B.

AU - Wanders, Lisa

AU - Erdos, Balázs

AU - Péter, Szabolcs

AU - Singh-Povel, Cécile M.

AU - de Vogel-van den Bosch, Johan

AU - Adriaens, Michiel E.

AU - Arts, Ilja C.W.

AU - Thijssen, Dick H.J.

AU - Feskens, Edith J.M.

AU - Goossens, Gijs H.

AU - Afman, Lydia A.

AU - Blaak, Ellen E.

PY - 2023/1/3

Y1 - 2023/1/3

N2 - Summary Precision nutrition based on metabolic phenotype may increase the effectiveness of interventions. In this proof-of-concept study, we investigated the effect of modulating dietary macronutrient composition according to muscle insulin-resistant (MIR) or liver insulin-resistant (LIR) phenotypes on cardiometabolic health. Women and men with MIR or LIR (n = 242, body mass index [BMI] 25–40 kg/m2, 40–75 years) were randomized to phenotype diet (PhenoDiet) group A or B and followed a 12-week high-monounsaturated fatty acid (HMUFA) diet or low-fat, high-protein, and high-fiber diet (LFHP) (PhenoDiet group A, MIR/HMUFA and LIR/LFHP; PhenoDiet group B, MIR/LFHP and LIR/HMUFA). PhenoDiet group B showed no significant improvements in the primary outcome disposition index, but greater improvements in insulin sensitivity, glucose homeostasis, serum triacylglycerol, and C-reactive protein compared with PhenoDiet group A were observed. We demonstrate that modulating macronutrient composition within the dietary guidelines based on tissue-specific insulin resistance (IR) phenotype enhances cardiometabolic health improvements. Clinicaltrials.gov registration: NCT03708419, CCMO registration NL63768.068.17.

AB - Summary Precision nutrition based on metabolic phenotype may increase the effectiveness of interventions. In this proof-of-concept study, we investigated the effect of modulating dietary macronutrient composition according to muscle insulin-resistant (MIR) or liver insulin-resistant (LIR) phenotypes on cardiometabolic health. Women and men with MIR or LIR (n = 242, body mass index [BMI] 25–40 kg/m2, 40–75 years) were randomized to phenotype diet (PhenoDiet) group A or B and followed a 12-week high-monounsaturated fatty acid (HMUFA) diet or low-fat, high-protein, and high-fiber diet (LFHP) (PhenoDiet group A, MIR/HMUFA and LIR/LFHP; PhenoDiet group B, MIR/LFHP and LIR/HMUFA). PhenoDiet group B showed no significant improvements in the primary outcome disposition index, but greater improvements in insulin sensitivity, glucose homeostasis, serum triacylglycerol, and C-reactive protein compared with PhenoDiet group A were observed. We demonstrate that modulating macronutrient composition within the dietary guidelines based on tissue-specific insulin resistance (IR) phenotype enhances cardiometabolic health improvements. Clinicaltrials.gov registration: NCT03708419, CCMO registration NL63768.068.17.

KW - precision nutrition

KW - dietary intervention trial

KW - tissue-specific insulin resistance

KW - metabotyping

KW - glucose homeostasis

KW - cardiometabolic health

U2 - 10.1016/j.cmet.2022.12.002

DO - 10.1016/j.cmet.2022.12.002

M3 - Article

C2 - 36599304

SN - 1550-4131

VL - 35

SP - 71-83.e5

JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -