@article{6fd87d25cab74cc188e629d1eb63dcf2,
title = "Auditory event-related potentials and associations with sensory patterns in children with autism spectrum disorder, developmental delay, and typical development",
abstract = "Atypical sensory response patterns are common in children with autism and developmental delay. Expanding on previous work, this observational electroencephalogram study assessed auditory event-related potentials and their associations with clinically evaluated sensory response patterns in children with autism spectrum disorder (n = 28), developmental delay (n = 17), and typical development (n = 39). Attention-orienting P3a responses were attenuated in autism spectrum disorder relative to both developmental delay and typical development, but early sensory N2 responses were attenuated in both autism spectrum disorder and developmental delay relative to typical development. Attenuated event-related potentials involving N2 or P3a components, or a P1 × N2 interaction, were related to more severe hyporesponsive or sensory-seeking response patterns across children with autism spectrum disorder and developmental delay. Thus, although attentional disruptions may be unique to autism spectrum disorder, sensory disruptions appear across developmental delay and are associated with atypical sensory behaviors.",
keywords = "autism spectrum disorders, development, sensory impairments, EVOKED POTENTIALS, TACTILE DEFENSIVENESS, RESPONSE PATTERNS, YOUNG-CHILDREN, SPEECH SOUNDS, FEATURES, BRAIN, N1, QUESTIONNAIRE, EXPERIENCES",
author = "Donkers, {Franc C. L.} and Mike Carlson and Schipul, {Sarah E.} and Aysenil Belger and Baranek, {Grace T.}",
note = "Funding Information: Atypical sensory behaviors are common in autism spectrum disorder and developmental delay. To date, it remains unclear whether sensory abnormalities are specific to autism spectrum disorder or reflect a broader pattern related to developmental disability in general. In this study, brain electrical responses to rarely occurring (novel) sounds and clinically evaluated sensory response patterns were investigated in 28 children with autism spectrum disorder, 17 children with developmental delay, and 39 typically developing children (typical development). Results showed that brain responses related to attention orienting were smaller in autism spectrum disorder relative to both developmental delay and typical development, but brain responses related to sensory processing were smaller in both autism spectrum disorder and developmental delay relative to typical development. The smaller brain responses were related to more severe sensory abnormalities across children with autism spectrum disorder and developmental delay. Thus, although brain attentional abnormalities may be unique to autism spectrum disorder, brain sensory abnormalities appear across developmental delay and are associated with atypical sensory behaviors. autism spectrum disorders development sensory impairments Eunice Kennedy Shriver National Institute of Child Health and Human Development https://doi.org/10.13039/100009633 R01-HD42168 Eunice Kennedy Shriver National Institute of Child Health and Human Development https://doi.org/10.13039/100009633 T32-HD40127 edited-state corrected-proof typesetter ts1 We thank the families whose participation made this study possible and the staff who collected the data. We acknowledge the Neurodevelopmental Disorders Research Center Autism Subject Registry at The University of North Carolina at Chapel Hill. We also acknowledge the contributions of Katherine Cleary in data collection, Anna Evans in data collection and preliminary analysis, John Bulluck in database management, John Sideris in data management and manuscript preparation, Jeanne Lovmo in assistance with subject recruitment and clinical testing, and Jeanine Blanchard and Sarah Gleason Wohlgemuth in manuscript preparation. Author contributions G.T.B. and A.B. designed the study, secured funding, and oversaw the data collection and analysis. S.E.S. conducted statistical analyses in consultation with G.T.B. and A.B., F.C.L.D. contributed to study design, data collection, and data analysis. All five authors contributed to the interpretation of the analysis, writing of the manuscript, and approved the final manuscript. Declaration of conflicting interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported in part by the Eunice Kennedy Shriver National Institute for Child Health and Human Development (R01-HD042168; T32-HD040127). ORCID iDs Franc CL Donkers https://orcid.org/0000-0002-8252-0426 Grace T Baranek https://orcid.org/0000-0002-5321-6353 Supplemental material Supplemental material for this article is available online. Publisher Copyright: {\textcopyright} The Author(s) 2019.",
year = "2020",
month = jul,
doi = "10.1177/1362361319893196",
language = "English",
volume = "24",
pages = "1093--1110",
journal = "Autism",
issn = "1362-3613",
publisher = "SAGE Publications Inc.",
number = "5",
}