@article{6eb0102ed4f047aab73b5bb56a642aba,
title = "Longitudinal associations of light-intensity physical activity with quality of life, functioning and fatigue after colorectal cancer",
abstract = "Purpose Evidence from cross-sectional studies suggests that higher levels of light-intensity physical activity (LPA) are associated with better health-related quality of life (HRQoL) in colorectal cancer (CRC) survivors. However, these associations have not been investigated in longitudinal studies that provide the opportunity to analyse how within-individual changes in LPA affect HRQoL. We investigated longitudinal associations of LPA with HRQoL outcomes in CRC survivors, from 6 weeks to 2 years post-treatment. Methods Data were used of a prospective cohort study among 325 stage I-III CRC survivors (67% men, mean age: 67 years), recruited between 2012 and 2016. Validated questionnaires were used to assess hours/week of LPA (SQUASH) and HRQoL outcomes (EORTC QLQ-C30, Checklist Individual Strength) at 6 weeks, and 6, 12 and 24 months post-treatment. We applied linear mixed regression to analyse longitudinal confounder-adjusted associations of LPA with HRQoL. Results We observed statistically significant longitudinal associations between more LPA and better global quality of life and physical, role and social functioning, and less fatigue over time. Intra-individual analysis showed that within-person increases in LPA (per 8 h/week) were related to improved HRQoL, including better global quality of life (beta = 1.67, 95% CI 0.71; 2.63; total range scale: 0-100) and less fatigue (beta = - 1.22, 95% CI - 2.37; - 0.07; scale: 20-140). Stratified analyses indicated stronger associations among participants below the median of moderate-to-vigorous physical activity (MVPA) at diagnosis. Conclusion Higher levels of LPA were longitudinally associated with better HRQoL and less fatigue in CRC survivors up to two years post-treatment. Further prospective studies using accelerometer data are necessary to inform development of interventions targeting LPA.",
keywords = "Colorectal cancer survivor, Light-intensity physical activity, Longitudinal, Health-related quality of life, Functioning, Fatigue, EORTC QLQ-C30, EUROPEAN-ORGANIZATION, HEALTH, QUESTIONNAIRE, GUIDELINES, VALIDITY, CLASSIFICATION, HEAD",
author = "{van Roekel}, {E. H.} and J. Duchateau and Bours, {M. J. L.} and {van Delden}, L. and Breedveld-Peters, {J. J. L.} and Koole, {J. L.} and M. Kenkhuis and {van den Brandt}, {P. A.} and Jansen, {R. L.} and I. Kant and {Lima Passos}, V. and K. Meijer and Breukink, {S. O.} and Janssen-Heijnen, {M. L. G.} and E. Keulen and Weijenberg, {M. P.}",
note = "Funding Information: We would like to thank all participants of the EnCoRe study and the health professionals in the three hospitals involved in the recruitment of participants of the study: Maastricht University Medical Centre+, VieCuri Medical Center and Zuyderland Medical Centre. We would also like to thank the MEMIC center for data and information management for facilitating the logistic processes and data management of our study. Finally, we would like to thank the research dieticians and research assistant who are responsible for patient inclusion and follow-up, performing home visits, as well as data collection and processing. Funding Information: This study was funded by the Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant programme (grant number 2016/1620). The EnCoRe study is also funded by grants from the Stichting Alpe d'HuZes within the research program 'Leven met kanker' of the Dutch Cancer Society (Grant No. UM-2010-4867 and UM-2012-5653), by grants from Kankeronderzoekfonds Limburg as part of Health Foundation Limburg (Grant No. 00005739) and by a grant of the Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant programme (grant number 2017/1619). E.H. van Roekel is funded by the Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant programme (grant number 2016/1620). J.J.L. Breedveld-Peters was funded and J.L. Koole is currently funded by Kankeronderzoekfonds Limburg as part of Health Foundation Limburg (Grant No. 00005739). M. Kenkhuis is funded by the Wereld Kanker Onderzoek Fonds (WKOF), as part of the World Cancer Research Fund International grant programme (grant number 2017/1619). Acknowledgements Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = nov,
doi = "10.1007/s11136-020-02566-7",
language = "English",
volume = "29",
pages = "2987--2998",
journal = "Quality of Life Research",
issn = "0962-9343",
publisher = "Springer, Cham",
number = "11",
}