@article{58643d42020747b4b8b47732615ef54f,
title = "High-Sensitivity Troponin-T and Cardiovascular Outcomes in the Community: Differences Between Women and Men",
abstract = "Objective: To evaluate associations of high-sensitivity cardiac troponin-T (cTnT) with cardiovascular disease (CVD), heart failure (HF), and mortality in community-dwelling women and men. Participants and Methods: A total of 8226 adults from the Prevention of Renal and Vascular End-stage Disease (PREVEND) cohort (1997 e1998) were enrolled in a prospective observational study (mean age: 49 years; 50.2% women). Sex-speci fic associations of cTnT levels with future clinical outcomes were evaluated using adjusted Cox-regression models. Results: Measurable cTnT levels (3 ng/L) were detected in 1102 women (26.7%) and in 2396 men (58.5%). Baseline cTnT levels were associated with a greater risk of developing CVD in women than men [Hazard ratio (HRwomen), 1.48 per unit increase in log 2-cTnT; 95% CI, 1.21 to 1.81 vs HRmen, 1.20; 95% CI, 1.07 to 1.35; P-interaction <.001]. Similar sex-related differences were observed for HF (P interaction = .005) and mortality (P-interaction = .008). Further, compared with referent category (cTnT",
keywords = "ONSET HEART-FAILURE, CARDIAC TROPONIN, NATRIURETIC PEPTIDE, PROGNOSTIC VALUE, ATRIAL-FIBRILLATION, SEX-DIFFERENCES, FOLLOW-UP, RISK, MORTALITY, EVENTS",
author = "Navin Suthahar and Meems, {Laura M. G.} and {van Veldhuisen}, {Dirk J.} and Walter, {Joan E.} and Gansevoort, {Ron T.} and Stephane Heymans and Blanche Schroen and {van der Harst}, Pim and Kootstra-Ros, {Jenny E.} and {van Empel}, Vanessa and Christian Mueller and Bakker, {Stephan J. L.} and {de Boer}, {Rudolf A.}",
note = "Funding Information: Potential Competing Interests: This work was supported by the Netherlands Heart Foundation (CVON SHE-PREDICTS-HF, grant 2017-21 to Drs de Boer, van Empel, Heymans, and Schroen). Further support is acknowledged from the Netherlands Heart Foundation (CVON DOSIS, grant 2014-40 to Dr de Boer, and CVON RED-CVD, grant 2017-11 to Dr de Boer); and the Innovational Research Incentives Scheme program of the Netherlands Organization for Scientific Research ( NWO VIDI, grant 917.13.350 to Dr de Boer), and the European Research Council Grant (ERC CoG 818715, SECRETE-HF) to Dr de Boer. The PREVEND study was financially supported by grant E.013 of the Dutch Kidney Foundation . The research leading to these results has received funding from the European Union Commission{\textquoteright}s Seventh Framework programme under grant agreement N° 305507 (HOMAGE), N° 602904 (FIBROTARGETS). The UMCG, which employs several of the authors has received research grants and/or fees from AstraZeneca , Abbott , Bristol-Myers Squibb , Novartis , Novo Nordisk and Roche . Dr de Boer has received speaker fees from Abbott, AstraZeneca, Novartis, and Roche. The remaining authors report no conflicts of interest. Funding Information: Potential Competing Interests: This work was supported by the Netherlands Heart Foundation (CVON SHE-PREDICTS-HF, grant 2017-21 to Drs de Boer, van Empel, Heymans, and Schroen). Further support is acknowledged from the Netherlands Heart Foundation (CVON DOSIS, grant 2014-40 to Dr de Boer, and CVON RED-CVD, grant 2017-11 to Dr de Boer); and the Innovational Research Incentives Scheme program of the Netherlands Organization for Scientific Research (NWO VIDI, grant 917.13.350 to Dr de Boer), and the European Research Council Grant (ERC CoG 818715, SECRETE-HF) to Dr de Boer. The PREVEND study was financially supported by grant E.013 of the Dutch Kidney Foundation. The research leading to these results has received funding from the European Union Commission's Seventh Framework programme under grant agreement N? 305507 (HOMAGE), N? 602904 (FIBROTARGETS). The UMCG, which employs several of the authors has received research grants and/or fees from AstraZeneca, Abbott, Bristol-Myers Squibb, Novartis, Novo Nordisk and Roche. Dr de Boer has received speaker fees from Abbott, AstraZeneca, Novartis, and Roche. The remaining authors report no conflicts of interest. Publisher Copyright: {\textcopyright} 2020 Mayo Foundation for Medical Education and Research",
year = "2020",
month = jun,
doi = "10.1016/j.mayocp.2020.01.017",
language = "English",
volume = "95",
pages = "1158--1168",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "6",
}