@inbook{53b021d046004c7f8f6e03bc3d1afc8c,
title = "Multicomponent Synthesis: Cohesive Integration of Green Chemistry Principles",
abstract = "The application of multicomponent reactions (MCRs) in the generation of compound libraries has long been recognized as a key strategy for the development of lead matter in drug discovery. Given the numerous advantages that these processes possess not only from the ability to generate large numbers of diverse compounds but also from a sustainability perspective, it is somewhat surprising that MCRs have not enjoyed such a widespread application in downstream development and the later scale-up of pharmaceutical candidates. The current chapter provides an overview of the most common MCRs with a critical focus on their perceived benefits as a sustainable technology. In addition, an overview of the combination of MCRs with other “green” technologies such as both biocatalysis and flow chemistry is also provided.",
keywords = "Asymmetric synthesis, Biginelli, Biocatalysis, Drug discovery, Flow chemistry, Green chemistry, Hantzsch, Isocyanide, Mannich, Mechanisms, Multicomponent reactions, Passerini, Petasis, Selectivity, Strecker, Ugi",
author = "Razvan Cioc and Eelco Ruijter and Orru, {Romano V.A.}",
note = "Publisher Copyright: {\textcopyright} 2022, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2022",
month = jan,
day = "1",
doi = "10.1007/978-1-0716-1579-9_8",
language = "English",
series = "Methods in Pharmacology and Toxicology",
publisher = "Humana Press",
pages = "237--267",
booktitle = "Green Chemistry in Drug Discovery",
address = "United States",
}