40-Hz steady state response in Alzheimer's disease and mild cognitive impairment

J.A. van Deursen, E.F.P.M. Vuurman*, V.H.J.M. van Kranen-Mastenbroek, F.R.J. Verhey, W.J. Riedel

*Corresponding author for this work

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The 40-Hz steady state response (SSR) reflects early sensory processing and can be measured with electroencephalography (EEG). The current study compared the 40-Hz SSR in groups consisting of mild Alzheimer's disease patients (AD) (n=15), subjects with mild cognitive impairment (MCI) (n=20) and healthy elderly control subjects (n=20). All participants were naive for psychoactive drugs. Auditory click trains at a frequency of 40-Hz evoked the 40-Hz SSR. To evaluate test-retest reliability (TRR), subjects underwent a similar assessment 1 week after the first. The results showed a high TRR and a significant increase of 40-Hz SSR power in the AD group compared to MCI and controls. Furthermore a moderate correlation between 40-Hz SSR power and cognitive performance as measured by ADAS-cog was shown. The results suggest that 40-Hz SSR might be an interesting candidate marker of disease progression.
Original languageEnglish
Pages (from-to)24-30
JournalNeurobiology of Aging
Issue number1
Publication statusPublished - 1 Jan 2011

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