40-Hz steady state response in Alzheimer's disease and mild cognitive impairment

J.A. van Deursen; E.F.P.M. Vuurman; V.H.J.M. van Kranen-Mastenbroek; F.R.J. Verhey; W.J. Riedel

doi:10.1016/j.neurobiolaging.2009.01.002

40-Hz steady state response in Alzheimer's disease and mild cognitive impairment

J.A. van Deursen, E.F.P.M. Vuurman^*, V.H.J.M. van Kranen-Mastenbroek, F.R.J. Verhey, W.J. Riedel

^*Corresponding author for this work

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Abstract

The 40-Hz steady state response (SSR) reflects early sensory processing and can be measured with electroencephalography (EEG). The current study compared the 40-Hz SSR in groups consisting of mild Alzheimer's disease patients (AD) (n=15), subjects with mild cognitive impairment (MCI) (n=20) and healthy elderly control subjects (n=20). All participants were naive for psychoactive drugs. Auditory click trains at a frequency of 40-Hz evoked the 40-Hz SSR. To evaluate test-retest reliability (TRR), subjects underwent a similar assessment 1 week after the first. The results showed a high TRR and a significant increase of 40-Hz SSR power in the AD group compared to MCI and controls. Furthermore a moderate correlation between 40-Hz SSR power and cognitive performance as measured by ADAS-cog was shown. The results suggest that 40-Hz SSR might be an interesting candidate marker of disease progression.

Original language	English
Pages (from-to)	24-30
Journal	Neurobiology of Aging
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.neurobiolaging.2009.01.002
Publication status	Published - 1 Jan 2011

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10.1016/j.neurobiolaging.2009.01.002

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title = "40-Hz steady state response in Alzheimer's disease and mild cognitive impairment",

abstract = "The 40-Hz steady state response (SSR) reflects early sensory processing and can be measured with electroencephalography (EEG). The current study compared the 40-Hz SSR in groups consisting of mild Alzheimer's disease patients (AD) (n=15), subjects with mild cognitive impairment (MCI) (n=20) and healthy elderly control subjects (n=20). All participants were naive for psychoactive drugs. Auditory click trains at a frequency of 40-Hz evoked the 40-Hz SSR. To evaluate test-retest reliability (TRR), subjects underwent a similar assessment 1 week after the first. The results showed a high TRR and a significant increase of 40-Hz SSR power in the AD group compared to MCI and controls. Furthermore a moderate correlation between 40-Hz SSR power and cognitive performance as measured by ADAS-cog was shown. The results suggest that 40-Hz SSR might be an interesting candidate marker of disease progression.",

author = "{van Deursen}, J.A. and E.F.P.M. Vuurman and {van Kranen-Mastenbroek}, V.H.J.M. and F.R.J. Verhey and W.J. Riedel",

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AU - van Deursen, J.A.

AU - Vuurman, E.F.P.M.

AU - van Kranen-Mastenbroek, V.H.J.M.

AU - Verhey, F.R.J.

AU - Riedel, W.J.

PY - 2011/1/1

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N2 - The 40-Hz steady state response (SSR) reflects early sensory processing and can be measured with electroencephalography (EEG). The current study compared the 40-Hz SSR in groups consisting of mild Alzheimer's disease patients (AD) (n=15), subjects with mild cognitive impairment (MCI) (n=20) and healthy elderly control subjects (n=20). All participants were naive for psychoactive drugs. Auditory click trains at a frequency of 40-Hz evoked the 40-Hz SSR. To evaluate test-retest reliability (TRR), subjects underwent a similar assessment 1 week after the first. The results showed a high TRR and a significant increase of 40-Hz SSR power in the AD group compared to MCI and controls. Furthermore a moderate correlation between 40-Hz SSR power and cognitive performance as measured by ADAS-cog was shown. The results suggest that 40-Hz SSR might be an interesting candidate marker of disease progression.

AB - The 40-Hz steady state response (SSR) reflects early sensory processing and can be measured with electroencephalography (EEG). The current study compared the 40-Hz SSR in groups consisting of mild Alzheimer's disease patients (AD) (n=15), subjects with mild cognitive impairment (MCI) (n=20) and healthy elderly control subjects (n=20). All participants were naive for psychoactive drugs. Auditory click trains at a frequency of 40-Hz evoked the 40-Hz SSR. To evaluate test-retest reliability (TRR), subjects underwent a similar assessment 1 week after the first. The results showed a high TRR and a significant increase of 40-Hz SSR power in the AD group compared to MCI and controls. Furthermore a moderate correlation between 40-Hz SSR power and cognitive performance as measured by ADAS-cog was shown. The results suggest that 40-Hz SSR might be an interesting candidate marker of disease progression.

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40-Hz steady state response in Alzheimer's disease and mild cognitive impairment

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