The 40-Hz steady state response (SSR) reflects early sensory processing and can be measured with electroencephalography (EEG). The current study compared the 40-Hz SSR in groups consisting of mild Alzheimer's disease patients (AD) (n=15), subjects with mild cognitive impairment (MCI) (n=20) and healthy elderly control subjects (n=20). All participants were naive for psychoactive drugs. Auditory click trains at a frequency of 40-Hz evoked the 40-Hz SSR. To evaluate test-retest reliability (TRR), subjects underwent a similar assessment 1 week after the first. The results showed a high TRR and a significant increase of 40-Hz SSR power in the AD group compared to MCI and controls. Furthermore a moderate correlation between 40-Hz SSR power and cognitive performance as measured by ADAS-cog was shown. The results suggest that 40-Hz SSR might be an interesting candidate marker of disease progression.
|Journal||Neurobiology of Aging|
|Publication status||Published - 1 Jan 2011|
van Deursen, J. A., Vuurman, E. F. P. M., van Kranen-Mastenbroek, V. H. J. M., Verhey, F. R. J., & Riedel, W. J. (2011). 40-Hz steady state response in Alzheimer's disease and mild cognitive impairment. Neurobiology of Aging, 32(1), 24-30. https://doi.org/10.1016/j.neurobiolaging.2009.01.002