Agonist-induced modulation of glycocalyx barrier properties in the microcirculation : role in blood volume recruitment and oxygen exchange in the heart

J. Brands

doi:10.26481/dis.20101029jb

Agonist-induced modulation of glycocalyx barrier properties in the microcirculation : role in blood volume recruitment and oxygen exchange in the heart

J. Brands

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Research output: Thesis › Doctoral Thesis › Internal

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Abstract

This dissertation research studies the role of the glycocalyx, a gel layer on the inside of all blood vessels in the heart. The glycocalyx turns out to behave as a thick non-stick layer that prevents damaging parts to stick to the wall and as an extra space for blood when more oxygen needs to be transported from the blood to the heart. Temporary adjustments of this layer appear to positively influence the blood and oxygen supply, but when this layer is damaged, that does not happen. Repair of a damaged glycocalyx could in the future be a possible therapy for patients suffering from chest pain.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Maastricht University
Supervisors/Advisors	Vink, Hans, Supervisor Spaan, J.A.E., Supervisor, External person van Teeffelen, Jurgen, Co-Supervisor
Award date	29 Oct 2010
Place of Publication	Maastricht
Publisher	Maastricht University
Print ISBNs	9789064644108
DOIs	https://doi.org/10.26481/dis.20101029jb
Publication status	Published - 1 Jan 2010

Keywords

glycocalyx
blood vessels

Access to Document

10.26481/dis.20101029jb

Full TextFinal published version, 2.46 MB
CoverFinal published version, 44.8 KB
AbstractFinal published version, 178 KB
PropositionsFinal published version, 549 KB

Cite this

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