TY - JOUR
T1 - 273rd ENMC International workshop
T2 - Clinico-Sero-morphological classification of the Antisynthetase syndrome. Amsterdam, The Netherlands, 27-29 October 2023
AU - Stenzel, Werner
AU - Mammen, Andrew L.
AU - Gallay, Laure
AU - Holzer, Marie Therese
AU - Kleefeld, Felix
AU - Benveniste, Olivier
AU - Allenbach, Yves
AU - Damoiseaux, Jan
AU - Danoff, Sonye K.
AU - Diederichsen, Louise
AU - Fiorentino, David
AU - Giannini, Margherita
AU - Kolsters, Lia
AU - Lundberg, Ingrid
AU - Mammen, Andrew L.
AU - Meyer, Alain
AU - Minopulou, Ioanna
AU - Preusse, Corinna
AU - Ruck, Tobias
AU - Tanboon, Jantima
AU - Tansley, Sarah L.
AU - Uzunhan, Yurdagul
AU - ENMC Antisynthetase Syndrome Study Group
N1 - Funding Information:
The workshops and next generation programme are made possible thanks to the financial support of the European Neuromuscular Centre (ENMC) and its Full Partners: Association Fran\u00E7aise contre les Myopathies (France), Deutsche Gesellschaft f\u00FCr Muskelkranke (Germany), Muscular Dystrophy Campaign (UK), Muskelsvindfonden (Denmark), Prinses Beatrix Spierfonds (The Netherlands), Schweizerische Stiftung f\u00FCr die Erforschung der Muskelkrankheiten (Switzerland), Spierziekten Nederland (The Netherlands), Telethon Foundation (Italy). In addition, we would like to thank the Associated Partners: Finnish Neuromuscular Association (Finland), \u00D6sterreichische Muskelforschung (Austria), SMA Europe, World Duchenne Organisation and World Muscle Society (WMS), and the members of the ENMC Company Forum: Amicus Therapeutics, Astellas, Biogen, Ionis Pharmaceuticals, Lupin Neuroscience, Novartis, Revvity, Roche, Sanofi and Santhera.
Publisher Copyright:
© 2024
PY - 2024/12/1
Y1 - 2024/12/1
N2 - Among the idiopathic inflammatory myopathies, patients harbouring an Antisynthetase syndrome exhibit a unique clinical picture, with characteristic signs such as myositis, interstitial lung disease, arthritis, rash, and/or fever. Characteristic morphological features on skeletal muscle biopsies differentiate Antisynthetase syndrome from other forms of myositis. Autoantibodies typically recognizing one of the members of the aminoacyl-tRNA synthetase family of proteins can be detected in the serum of such patients, with anti-Jo1 being most frequent. Until now, an international consensus definition of the Antisynthetase syndrome is lacking, hence this workshop has undertaken the task to inform about the clinical, morphological and autoantibody profiles of Antisynthetase syndrome. The authors also expand their aims by giving management and therapeutic strategies, and finally provide precise classification criteria for Antisynthetase syndrome.
AB - Among the idiopathic inflammatory myopathies, patients harbouring an Antisynthetase syndrome exhibit a unique clinical picture, with characteristic signs such as myositis, interstitial lung disease, arthritis, rash, and/or fever. Characteristic morphological features on skeletal muscle biopsies differentiate Antisynthetase syndrome from other forms of myositis. Autoantibodies typically recognizing one of the members of the aminoacyl-tRNA synthetase family of proteins can be detected in the serum of such patients, with anti-Jo1 being most frequent. Until now, an international consensus definition of the Antisynthetase syndrome is lacking, hence this workshop has undertaken the task to inform about the clinical, morphological and autoantibody profiles of Antisynthetase syndrome. The authors also expand their aims by giving management and therapeutic strategies, and finally provide precise classification criteria for Antisynthetase syndrome.
KW - Anti-synthetase syndrome
KW - Idiopathic inflammatory myopathies
KW - tRNA synthetase autoantibodies, ILD, arthritis
U2 - 10.1016/j.nmd.2024.104453
DO - 10.1016/j.nmd.2024.104453
M3 - Article
SN - 0960-8966
VL - 45
JO - Neuromuscular Disorders
JF - Neuromuscular Disorders
M1 - 104453
ER -