2025 European guideline on the management of Chlamydia trachomatis infections

John A. White; Nicole H. T. M. Dukers-Muijrers; Christian J. P. A. Hoebe; Chris R. Kenyon; Jonathan D. C. Ross; Magnus Unemo

doi:10.1177/09564624251323678

2025 European guideline on the management of Chlamydia trachomatis infections

John A. White
, Nicole H. T. M. Dukers-Muijrers
, Christian J. P. A. Hoebe
, Chris R. Kenyon
, Jonathan D. C. Ross
, Magnus Unemo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Sexually transmitted Chlamydia trachomatis infections remain common globally and most frequently are asymptomatic. The 2025 European C. trachomatis guideline provides up-to-date guidance regarding indications for testing and treatment of C. trachomatis infections. It includes advice on urogenital and extragenital C. trachomatis testing including the use of self-collected specimens; recommendation to use only validated NAATs for diagnosis; and recommendation to treat all C. trachomatis infections with doxycycline as first line in preference to single-dose azithromycin regimens. The absence of evidence and limited value of broad screening in asymptomatic populations for C. trachomatis infections is also discussed.

Original language	English
Pages (from-to)	434-449
Number of pages	16
Journal	International Journal of Std & Aids
Volume	36
Issue number	6
Early online date	1 Mar 2025
DOIs	https://doi.org/10.1177/09564624251323678
Publication status	Published - May 2025

Keywords

<italic>Chlamydia trachomatis</italic>
Europe
diagnosis
treatment
antibiotic
SEXUALLY-TRANSMITTED INFECTIONS
OF-CARE TESTS
COMBO 2 ASSAY
POLYMERASE-CHAIN-REACTION
PENILE-MEATAL SWABS
LOW-BIRTH-WEIGHT
1ST VOID URINE
NEISSERIA-GONORRHOEAE
MYCOPLASMA-GENITALIUM
PHARYNGEAL CHLAMYDIA

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10.1177/09564624251323678

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title = "2025 European guideline on the management of Chlamydia trachomatis infections",

abstract = "Sexually transmitted Chlamydia trachomatis infections remain common globally and most frequently are asymptomatic. The 2025 European C. trachomatis guideline provides up-to-date guidance regarding indications for testing and treatment of C. trachomatis infections. It includes advice on urogenital and extragenital C. trachomatis testing including the use of self-collected specimens; recommendation to use only validated NAATs for diagnosis; and recommendation to treat all C. trachomatis infections with doxycycline as first line in preference to single-dose azithromycin regimens. The absence of evidence and limited value of broad screening in asymptomatic populations for C. trachomatis infections is also discussed.",

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author = "White, \{John A.\} and Dukers-Muijrers, \{Nicole H. T. M.\} and Hoebe, \{Christian J. P. A.\} and Kenyon, \{Chris R.\} and Ross, \{Jonathan D. C.\} and Magnus Unemo",

year = "2025",

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language = "English",

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AU - White, John A.

AU - Dukers-Muijrers, Nicole H. T. M.

AU - Hoebe, Christian J. P. A.

AU - Kenyon, Chris R.

AU - Ross, Jonathan D. C.

AU - Unemo, Magnus

PY - 2025/5

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AB - Sexually transmitted Chlamydia trachomatis infections remain common globally and most frequently are asymptomatic. The 2025 European C. trachomatis guideline provides up-to-date guidance regarding indications for testing and treatment of C. trachomatis infections. It includes advice on urogenital and extragenital C. trachomatis testing including the use of self-collected specimens; recommendation to use only validated NAATs for diagnosis; and recommendation to treat all C. trachomatis infections with doxycycline as first line in preference to single-dose azithromycin regimens. The absence of evidence and limited value of broad screening in asymptomatic populations for C. trachomatis infections is also discussed.

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KW - Europe

KW - diagnosis

KW - treatment

KW - antibiotic

KW - SEXUALLY-TRANSMITTED INFECTIONS

KW - OF-CARE TESTS

KW - COMBO 2 ASSAY

KW - POLYMERASE-CHAIN-REACTION

KW - PENILE-MEATAL SWABS

KW - LOW-BIRTH-WEIGHT

KW - 1ST VOID URINE

KW - NEISSERIA-GONORRHOEAE

KW - MYCOPLASMA-GENITALIUM

KW - PHARYNGEAL CHLAMYDIA

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DO - 10.1177/09564624251323678

M3 - Article

SN - 0956-4624

VL - 36

SP - 434

EP - 449

JO - International Journal of Std & Aids

JF - International Journal of Std & Aids

IS - 6

ER -

2025 European guideline on the management of Chlamydia trachomatis infections

Abstract

Keywords

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