2-year outcomes of phased radiofrequency ablation for atrial fibrillation with the second-generation PVAC Gold ablation catheter

M N Klaver; L I S Wintgens; M C E F Wijffels; V F van Dijk; A Alipour; S M Chaldoupi; R Derksen; J Peper; J C Balt; L V A Boersma

doi:10.1007/s10840-022-01249-2

2-year outcomes of phased radiofrequency ablation for atrial fibrillation with the second-generation PVAC Gold ablation catheter

M N Klaver^*
, L I S Wintgens
, M C E F Wijffels
, V F van Dijk
, A Alipour
, S M Chaldoupi
, R Derksen
, J Peper
, J C Balt
, L V A Boersma

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PURPOSE: The second-generation multi-electrode catheter, PVAC Gold, was designed to improve the safe delivery of phased radiofrequency energy using a "single shot" approach for pulmonary vein isolation (PVI), while retaining efficacy. This large registry presents long-term performance in a daily practice setting.

METHODS: A total of 1011 patients undergoing first time ablation for atrial fibrillation (AF) using PVAC Gold were included, 639 patients with PVI for paroxysmal AF (PAF PVI) and 372 patients with persistent or long-standing persistent AF, divided into 175 patients receiving PVI only (PersAF PVI) and 197 patients receiving PVI with additional substrate ablation (PersAF PVI +).

RESULTS: At 24-month follow-up, single procedure freedom from atrial tachyarrhythmia (ATA) was 58% (368/639) in the PAF PVI group, 44% (77/175) in the PersAF PVI group, and 29% (57/197) in the PersAF PVI + group. Allowing one repeat procedure in 33% of patients, 76%, 65%, and 54% were free from ATA at 24 months, respectively. Pulmonary vein reconnection was observed in 98% of patients with recurrent arrhythmia after PVI.

CONCLUSIONS: Although phased RF ablation with PVAC Gold is quick and safe, the efficacy outcomes are modest compared to current mainstream ablation strategies.

Original language	English
Pages (from-to)	471-480
Number of pages	10
Journal	Journal of Interventional Cardiac Electrophysiology
Volume	65
Issue number	2
Early online date	23 May 2022
DOIs	https://doi.org/10.1007/s10840-022-01249-2
Publication status	Published - Nov 2022

Keywords

Atrial fibrillation
Catheter ablation
Long-term performance
PULMONARY VEIN ISOLATION
PVAC Gold
Phased radiofrequency
Pulmonary vein isolation

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Klaver, M. N., Wintgens, L. I. S., Wijffels, M. C. E. F., van Dijk, V. F., Alipour, A., Chaldoupi, S. M., Derksen, R., Peper, J., Balt, J. C., & Boersma, L. V. A. (2022). 2-year outcomes of phased radiofrequency ablation for atrial fibrillation with the second-generation PVAC Gold ablation catheter. Journal of Interventional Cardiac Electrophysiology, 65(2), 471-480. https://doi.org/10.1007/s10840-022-01249-2

@article{b6d58af6120a47b6a5920bf97b9f9028,

title = "2-year outcomes of phased radiofrequency ablation for atrial fibrillation with the second-generation PVAC Gold ablation catheter",

abstract = "PURPOSE: The second-generation multi-electrode catheter, PVAC Gold, was designed to improve the safe delivery of phased radiofrequency energy using a {"}single shot{"} approach for pulmonary vein isolation (PVI), while retaining efficacy. This large registry presents long-term performance in a daily practice setting.METHODS: A total of 1011 patients undergoing first time ablation for atrial fibrillation (AF) using PVAC Gold were included, 639 patients with PVI for paroxysmal AF (PAF PVI) and 372 patients with persistent or long-standing persistent AF, divided into 175 patients receiving PVI only (PersAF PVI) and 197 patients receiving PVI with additional substrate ablation (PersAF PVI +).RESULTS: At 24-month follow-up, single procedure freedom from atrial tachyarrhythmia (ATA) was 58\% (368/639) in the PAF PVI group, 44\% (77/175) in the PersAF PVI group, and 29\% (57/197) in the PersAF PVI + group. Allowing one repeat procedure in 33\% of patients, 76\%, 65\%, and 54\% were free from ATA at 24 months, respectively. Pulmonary vein reconnection was observed in 98\% of patients with recurrent arrhythmia after PVI.CONCLUSIONS: Although phased RF ablation with PVAC Gold is quick and safe, the efficacy outcomes are modest compared to current mainstream ablation strategies.",

keywords = "Atrial fibrillation, Catheter ablation, Long-term performance, PULMONARY VEIN ISOLATION, PVAC Gold, Phased radiofrequency, Pulmonary vein isolation",

author = "Klaver, \{M N\} and Wintgens, \{L I S\} and Wijffels, \{M C E F\} and \{van Dijk\}, \{V F\} and A Alipour and Chaldoupi, \{S M\} and R Derksen and J Peper and Balt, \{J C\} and Boersma, \{L V A\}",

note = "{\textcopyright} 2022. The Author(s).",

year = "2022",

month = nov,

doi = "10.1007/s10840-022-01249-2",

language = "English",

volume = "65",

pages = "471--480",

journal = "Journal of Interventional Cardiac Electrophysiology",

issn = "1383-875X",

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Klaver, MN, Wintgens, LIS, Wijffels, MCEF, van Dijk, VF, Alipour, A, Chaldoupi, SM, Derksen, R, Peper, J, Balt, JC & Boersma, LVA 2022, '2-year outcomes of phased radiofrequency ablation for atrial fibrillation with the second-generation PVAC Gold ablation catheter', Journal of Interventional Cardiac Electrophysiology, vol. 65, no. 2, pp. 471-480. https://doi.org/10.1007/s10840-022-01249-2

TY - JOUR

T1 - 2-year outcomes of phased radiofrequency ablation for atrial fibrillation with the second-generation PVAC Gold ablation catheter

AU - Klaver, M N

AU - Wintgens, L I S

AU - Wijffels, M C E F

AU - van Dijk, V F

AU - Alipour, A

AU - Chaldoupi, S M

AU - Derksen, R

AU - Peper, J

AU - Balt, J C

AU - Boersma, L V A

PY - 2022/11

Y1 - 2022/11

N2 - PURPOSE: The second-generation multi-electrode catheter, PVAC Gold, was designed to improve the safe delivery of phased radiofrequency energy using a "single shot" approach for pulmonary vein isolation (PVI), while retaining efficacy. This large registry presents long-term performance in a daily practice setting.METHODS: A total of 1011 patients undergoing first time ablation for atrial fibrillation (AF) using PVAC Gold were included, 639 patients with PVI for paroxysmal AF (PAF PVI) and 372 patients with persistent or long-standing persistent AF, divided into 175 patients receiving PVI only (PersAF PVI) and 197 patients receiving PVI with additional substrate ablation (PersAF PVI +).RESULTS: At 24-month follow-up, single procedure freedom from atrial tachyarrhythmia (ATA) was 58% (368/639) in the PAF PVI group, 44% (77/175) in the PersAF PVI group, and 29% (57/197) in the PersAF PVI + group. Allowing one repeat procedure in 33% of patients, 76%, 65%, and 54% were free from ATA at 24 months, respectively. Pulmonary vein reconnection was observed in 98% of patients with recurrent arrhythmia after PVI.CONCLUSIONS: Although phased RF ablation with PVAC Gold is quick and safe, the efficacy outcomes are modest compared to current mainstream ablation strategies.

AB - PURPOSE: The second-generation multi-electrode catheter, PVAC Gold, was designed to improve the safe delivery of phased radiofrequency energy using a "single shot" approach for pulmonary vein isolation (PVI), while retaining efficacy. This large registry presents long-term performance in a daily practice setting.METHODS: A total of 1011 patients undergoing first time ablation for atrial fibrillation (AF) using PVAC Gold were included, 639 patients with PVI for paroxysmal AF (PAF PVI) and 372 patients with persistent or long-standing persistent AF, divided into 175 patients receiving PVI only (PersAF PVI) and 197 patients receiving PVI with additional substrate ablation (PersAF PVI +).RESULTS: At 24-month follow-up, single procedure freedom from atrial tachyarrhythmia (ATA) was 58% (368/639) in the PAF PVI group, 44% (77/175) in the PersAF PVI group, and 29% (57/197) in the PersAF PVI + group. Allowing one repeat procedure in 33% of patients, 76%, 65%, and 54% were free from ATA at 24 months, respectively. Pulmonary vein reconnection was observed in 98% of patients with recurrent arrhythmia after PVI.CONCLUSIONS: Although phased RF ablation with PVAC Gold is quick and safe, the efficacy outcomes are modest compared to current mainstream ablation strategies.

KW - Atrial fibrillation

KW - Catheter ablation

KW - Long-term performance

KW - PULMONARY VEIN ISOLATION

KW - PVAC Gold

KW - Phased radiofrequency

KW - Pulmonary vein isolation

U2 - 10.1007/s10840-022-01249-2

DO - 10.1007/s10840-022-01249-2

M3 - Article

C2 - 35604577

SN - 1383-875X

VL - 65

SP - 471

EP - 480

JO - Journal of Interventional Cardiac Electrophysiology

JF - Journal of Interventional Cardiac Electrophysiology

IS - 2

ER -

2-year outcomes of phased radiofrequency ablation for atrial fibrillation with the second-generation PVAC Gold ablation catheter

Abstract

Keywords

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