TY - JOUR
T1 - Thinner inner retinal layers are associated with lower cognitive performance, lower brain volume, and altered white matter network structure-The Maastricht Study
AU - van der Heide, Frank C T
AU - Steens, Indra L M
AU - Limmen, Betsie
AU - Mokhtar, Sara
AU - van Boxtel, Martin P J
AU - Schram, Miranda T
AU - Köhler, Sebastian
AU - Kroon, Abraham A
AU - van der Kallen, Carla J H
AU - Dagnelie, Pieter C
AU - van Dongen, Martien C J M
AU - Eussen, Simone J P M
AU - Berendschot, Tos T J M
AU - Webers, Carroll A B
AU - van Greevenbroek, Marleen M J
AU - Koster, Annemarie
AU - van Sloten, Thomas T
AU - Jansen, Jacobus F A
AU - Backes, Walter H
AU - Stehouwer, Coen D A
PY - 2024/1
Y1 - 2024/1
N2 - INTRODUCTION: The retina may provide non-invasive, scalable biomarkers for monitoring cerebral neurodegeneration. METHODS: We used cross-sectional data from The Maastricht study (n = 3436; mean age 59.3 years; 48% men; and 21% with type 2 diabetes [the latter oversampled by design]). We evaluated associations of retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer thicknesses with cognitive performance and magnetic resonance imaging indices (global grey and white matter volume, hippocampal volume, whole brain node degree, global efficiency, clustering coefficient, and local efficiency). RESULTS: After adjustment, lower thicknesses of most inner retinal layers were significantly associated with worse cognitive performance, lower grey and white matter volume, lower hippocampal volume, and worse brain white matter network structure assessed from lower whole brain node degree, lower global efficiency, higher clustering coefficient, and higher local efficiency. DISCUSSION: The retina may provide biomarkers that are informative of cerebral neurodegenerative changes in the pathobiology of dementia.
AB - INTRODUCTION: The retina may provide non-invasive, scalable biomarkers for monitoring cerebral neurodegeneration. METHODS: We used cross-sectional data from The Maastricht study (n = 3436; mean age 59.3 years; 48% men; and 21% with type 2 diabetes [the latter oversampled by design]). We evaluated associations of retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer thicknesses with cognitive performance and magnetic resonance imaging indices (global grey and white matter volume, hippocampal volume, whole brain node degree, global efficiency, clustering coefficient, and local efficiency). RESULTS: After adjustment, lower thicknesses of most inner retinal layers were significantly associated with worse cognitive performance, lower grey and white matter volume, lower hippocampal volume, and worse brain white matter network structure assessed from lower whole brain node degree, lower global efficiency, higher clustering coefficient, and higher local efficiency. DISCUSSION: The retina may provide biomarkers that are informative of cerebral neurodegenerative changes in the pathobiology of dementia.
KW - brain structural connectivity
KW - brain volume
KW - clustering coefficient
KW - cognitive function
KW - cognitive performance
KW - global efficiency
KW - graph theory
KW - grey matter
KW - local efficiency
KW - magnetic resonance imaging (MRI)
KW - optical coherence tomography (OCT)
KW - retinal imaging
KW - retinal neurodegeneration
KW - white matter
KW - whole brain node degree
U2 - 10.1002/alz.13442
DO - 10.1002/alz.13442
M3 - Article
SN - 1552-5260
VL - 20
SP - 316
EP - 329
JO - Alzheimer's & Dementia
JF - Alzheimer's & Dementia
IS - 1
ER -