17 O relaxation times in the rat brain at 16.4 tesla

H.M. Wiesner, D.Z. Balla, G. Shajan, K. Scheffler, K. Ugurbil, W. Chen, K. Uludag, R. Pohmann

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Abstract

PURPOSE: Measurement of the cerebral metabolic rate of oxygen (CMRO2 ) by means of direct imaging of the 17 O signal can be a valuable tool in neuroscientific research. However, knowledge of the longitudinal and transverse relaxation times of different brain tissue types is required, which is difficult to obtain because of the low sensitivity of natural abundance H2 17 O measurements. METHODS: Using the improved sensitivity at a field strength of 16.4 Tesla, relaxation time measurements in the rat brain were performed in vivo and postmortem with relatively high spatial resolutions, using a chemical shift imaging sequence. RESULTS: In vivo relaxation times of rat brain were found to be T1 = 6.84 +/- 0.67 ms and T2 * = 1.77 +/- 0.04 ms. Postmortem H2 17 O relaxometry at enriched concentrations after inhalation of 17 O2 showed similar T2 * values for gray matter (1.87 +/- 0.04 ms) and white matter, significantly longer than muscle (1.27 +/- 0.05 ms) and shorter than cerebrospinal fluid (2.30 +/- 0.16 ms). CONCLUSION: Relaxation times of brain H2 17 O were measured for the first time in vivo in different types of tissues with high spatial resolution. Because the relaxation times of H2 17 O are expected to be independent of field strength, our results should help in optimizing the acquisition parameters for experiments also at other MRI field strengths. Magn Reson Med, 2015. (c) 2015 Wiley Periodicals, Inc.
Original languageEnglish
Pages (from-to)1886–1893
Number of pages8
JournalMagnetic Resonance in Medicine
Volume75
Issue number5
Early online date22 Jun 2015
DOIs
Publication statusPublished - May 2016

Keywords

  • relaxation times
  • brain water distribution
  • natural abundance oxygen-17
  • (H2O)-O-17
  • quadrupolar relaxation
  • X-Nuclei
  • quantification
  • spectroscopic imaging
  • MRSI
  • ultra-high field
  • NUCLEAR-MAGNETIC-RESONANCE
  • CEREBRAL OXYGEN-CONSUMPTION
  • SPIN-SPIN RELAXATION
  • IN-VIVO
  • BLOOD-FLOW
  • NATURAL-ABUNDANCE
  • NMR SENSITIVITY
  • WATER
  • SPECTROSCOPY
  • METABOLISM

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