17-Hydroxyprogesterone caproate in triplet pregnancy: an individual patient data meta-analysis

C. A. Combs; E. Schuit; S. N. Caritis; A. C. Lim; T. J. Garite; K. Maurel; D. Rouse; E. Thom; A. T. Tita; B. W. J. Mol

doi:10.1111/1471-0528.13779

17-Hydroxyprogesterone caproate in triplet pregnancy: an individual patient data meta-analysis

C. A. Combs^*, E. Schuit, S. N. Caritis, A. C. Lim, T. J. Garite, K. Maurel, D. Rouse, E. Thom, A. T. Tita, B. W. J. Mol

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Preterm birth complicates almost all triplet pregnancies and no preventive strategy has proven effective.To determine, using individual patient data (IPD) meta-analysis, whether the outcome of triplet pregnancy is affected by prophylactic administration of 17-hydroxyprogesterone caproate (17OHPc).We searched literature databases, trial registries and references in published articles.Randomised controlled trials (RCTs) of progestogens versus control that included women with triplet pregnancies.Investigators from identified RCTs collaborated on the protocol and contributed their IPD. The primary outcome was a composite measure of adverse perinatal outcome. The secondary outcome was the rate of birth before 32?weeks of gestation. Other pre-specified outcomes included randomisation-to-delivery interval and rates of birth at

Original language	English
Pages (from-to)	682-690
Journal	Bjog-an International Journal of Obstetrics and Gynaecology
Volume	123
Issue number	5
DOIs	https://doi.org/10.1111/1471-0528.13779
Publication status	Published - Apr 2016

Keywords

17-Hydroxyprogesterone caproate
multiple gestation
preterm birth prevention
progestogens
triplet pregnancy

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10.1111/1471-0528.13779

Cite this

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abstract = "Preterm birth complicates almost all triplet pregnancies and no preventive strategy has proven effective.To determine, using individual patient data (IPD) meta-analysis, whether the outcome of triplet pregnancy is affected by prophylactic administration of 17-hydroxyprogesterone caproate (17OHPc).We searched literature databases, trial registries and references in published articles.Randomised controlled trials (RCTs) of progestogens versus control that included women with triplet pregnancies.Investigators from identified RCTs collaborated on the protocol and contributed their IPD. The primary outcome was a composite measure of adverse perinatal outcome. The secondary outcome was the rate of birth before 32?weeks of gestation. Other pre-specified outcomes included randomisation-to-delivery interval and rates of birth at ",

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AU - Combs, C. A.

AU - Schuit, E.

AU - Caritis, S. N.

AU - Lim, A. C.

AU - Garite, T. J.

AU - Maurel, K.

AU - Rouse, D.

AU - Thom, E.

AU - Tita, A. T.

AU - Mol, B. W. J.

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KW - 17-Hydroxyprogesterone caproate

KW - multiple gestation

KW - preterm birth prevention

KW - progestogens

KW - triplet pregnancy

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17-Hydroxyprogesterone caproate in triplet pregnancy: an individual patient data meta-analysis

Abstract

Keywords

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