1.14 Calcium Phosphates and Bone Induction ☆

H. Yuan, D. Barbieri, X. Luo, C.a. Van Blitterswijk, J.d. De Bruijn

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic


Calcium phosphates (caps) have a widespread use in bone repair and regeneration due to their osteoconductive and bioactive (bone bonding) nature. In the past decade, it has become apparent that a sub-group of caps with specific physico-chemical properties have the ability to induce bone formation in ectopic sites (ie, intramuscular or sub-cutaneously). In this chapter, we summarize the scientific evidence of cap induced bone formation, describe material properties required for bone induction and discuss possible underlying mechanisms. In addition, we also provide data on the clinical efficacy of this unique group of caps.
Original languageEnglish
Title of host publicationComprehensive Biomaterials II
Number of pages17
ISBN (Print)9780081006924
Publication statusPublished - 2017

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