Calcium phosphates (caps) have a widespread use in bone repair and regeneration due to their osteoconductive and bioactive (bone bonding) nature. In the past decade, it has become apparent that a sub-group of caps with specific physico-chemical properties have the ability to induce bone formation in ectopic sites (ie, intramuscular or sub-cutaneously). In this chapter, we summarize the scientific evidence of cap induced bone formation, describe material properties required for bone induction and discuss possible underlying mechanisms. In addition, we also provide data on the clinical efficacy of this unique group of caps.
|Title of host publication||Comprehensive Biomaterials II|
|Number of pages||17|
|Publication status||Published - 2017|
Yuan, H., Barbieri, D., Luo, X., Van Blitterswijk, C. A., & De Bruijn, J. D. (2017). 1.14 Calcium Phosphates and Bone Induction ☆. In Comprehensive Biomaterials II (pp. 333-349). Elsevier. https://doi.org/10.1016/B978-0-12-803581-8.10241-3