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Research Output 1994 2019

2019

[F-18] BODIPY-triglyceride-containing chylomicron-like particles as an imaging agent for brown adipose tissue in vivo

Paulus, A., Drude, N., Nascimento, E. B. M., Buhl, E. M., Berbee, J. F. P., Rensen, P. C. N., Lichtenbelt, W. D. V. M., Mottaghy, F. M. & Bauwens, M., 25 Feb 2019, In : Scientific Reports. 9, p. 1-9 9 p., 2706.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Early evening light mitigates sleep compromising physiological and alerting responses to subsequent late evening light

te Kulve, M., Schlangen, L. J. M. & Lichtenbelt, W. D. V. M., 5 Nov 2019, In : Scientific Reports. 9, 12 p., 16064.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effect of l-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study

Boon, M. R., Hanssen, M. J. W., Brans, B., Hulsman, C. J. M., Hoeks, J., Nahon, K. J., Bakker, C., van Klinken, J. B., Havekes, B., Schaart, G., Jazet, I. M., Rensen, P. C. N. & Lichtenbelt, W. D. V. M., Jan 2019, In : Diabetologia. 62, 1, p. 112-122 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effect of local skin blood flow during light and medium activities on local skin temperature predictions

Vesela, S., Kingma, B. R. M., Frijns, A. J. H. & Lichtenbelt, W. D. V. M., Aug 2019, In : Journal of Thermal Biology. 84, p. 439-450 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Exploring the human thermoneutral zone - A dynamic approach

Pallubinsky, H., Schellen, L. & van Marken Lichtenbelt, W. D., Jan 2019, In : Journal of Thermal Biology. 79, p. 199-208 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Human brown adipose tissue: Underestimated target in metabolic disease?

Moonen, M. P. B., Nascimento, E. B. M. & Lichtenbelt, W. D. V. M., Jan 2019, In : Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids. 1864, 1, p. 104-112 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2018

Brown and beige adipose tissues: phenotype and metabolic potential in mice and men

Chechi, K., Lichtenbelt, W. V. M. & Richard, D., Feb 2018, In : Journal of Applied Physiology. 124, 2, p. 482-496 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Cardiovascular responses to cold and submaximal exercise in patients with coronary artery disease

Valtonen, R. I. P., Kiviniemi, A., Hintsala, H. E., Ryti, N. R. I., Kentta, T., Huikuri, H. V., Perkiomaki, J., Crandall, C., Lichtenbelt, W. V. M., Alen, M., Rintamaki, H., Mantysaari, M., Hautala, A., Jaakkola, J. J. K. & Ikaheimo, T. M., Oct 2018, In : American Journal of Physiology-regulatory Integrative and Comparative Physiology. 315, 4, p. R768-R776 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle

Wefers, J., van Moorsel, D., Hansen, J., Connell, N. J., Havekes, B., Hoeks, J., Lichtenbelt, W. D. V. M., Duez, H., Phielix, E., Kalsbeek, A., Boekschoten, M. V., Hooiveld, G. J., Hesselink, M. K. C., Kersten, S., Staels, B., Scheer, F. A. J. L. & Schrauwen, P., 24 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 30, p. 7789-7794 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Correlated colour temperature of morning light influences alertness and body temperature

te Kulve, M., Schlangen, L., Schellen, L., Souman, J. L. & Lichtenbelt, W. V. M., 1 Mar 2018, In : Physiology & Behavior. 185, p. 1-13 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Gene Expression o Endocannabinoid System Components in Skeletal Muscle and Adipose Tissue of South Asians and White Caucasians with Overweight

Nahon, K. J., Kantae, V., den Haan, R., Hanssen, M. J. W., Harms, A. C., van der Stelt, M., Hankemeier, T., Jazet, I. M., Lichtenbelt, W. D. V. M., Rensen, P. C. N. & Boon, M. R., Aug 2018, In : Obesity. 26, 8, p. 1332-1337 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Genetic Markers of Brown Adipose Tissue Identity and In Vitro Brown Adipose Tissue Activity in Humans

Nascimento, E. B. M., Sparks, L. M., Divoux, A., van Gisbergen, M. W., Broeders, E. P. M., Jorgensen, J. A., Schaart, G., Bouvy, N. D., Lichtenbelt, W. D. V. M. & Schrauwen, P., 1 Jan 2018, In : Obesity. 26, 1, p. 135-140 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Interactions between the perception of light and temperature

te Kulve, M., Schlangen, L. & Lichtenbelt, W. V. M., Nov 2018, In : Indoor Air. 28, 6, p. 881-891 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Modulation of thermogenesis and metabolic health: a built environment perspective

Lichtenbelt, W. D. V. M., Pallubinsky, H. & te Kulve, M., Dec 2018, In : Obesity Reviews. 19, p. 94-101 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2017

Brown Adipose Tissue: The Magic Bullet?

Schrauwen, P. & Lichtenbelt, W. V. M., Mar 2017, In : Obesity. 25, 3, p. 499-499 1 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Brown adipose tissue and lipid metabolism imaging

Paulus, A., Lichtenbelt, W. V. M., Mottaghy, F. M. & Bauwens, M., 1 Nov 2017, In : Methods. 130, p. 105-113 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Exploring internal body heat balance to understand thermal sensation

Kingma, B. R. M., Schweiker, M., Wagner, A. & Lichtenbelt, W. D. V. M., 2017, In : Building Research and Information. 45, 7, p. 808-818 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Healthy excursions outside the thermal comfort zone

van Marken Lichtenbelt, W., Hanssen, M., Pallubinsky, H., Kingma, B. & Schellen, L., 2017, In : Building Research and Information. 45, 7, p. 819-827 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

LysoPC-acyl C16: 0 is associated with brown adipose tissue activity in men

Boon, M. R., Bakker, L. E. H., Prehn, C., Adamski, J., Vosselman, M. J., Jazet, I. M., Arias-Bouda, L. M. P., van Lichtenbelt, W. D. M., van Dijk, K. W., Rensen, P. C. N. & Mook-Kanamori, D. O., May 2017, In : Metabolomics. 13, 5, 9 p., 48.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

South Asian men have lower expression of IFN signalling genes in white adipose tissue and skeletal muscle compared with white men

van Dam, A. D., Hanssen, M. J. W., van Eenige, R., Quinten, E., Sips, H. C., Hulsman, C. J. M., Jazet, I. M., Lichtenbelt, W. D. V. M., Ottenhoff, T. H. M., Haks, M. C., Rensen, P. C. N. & Boon, M. R., Dec 2017, In : Diabetologia. 60, 12, p. 2525-2528 4 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Synthesis, radiosynthesis and in vitro evaluation of 18F-Bodipy-C16/triglyceride as a dual modal imaging agent for brown adipose tissue

Paulus, A., Maenen, M., Drude, N., Nascimento, E. B. M., Lichtenbelt, W. D. V. M., Mottaghy, F. M. & Bauwens, M., 17 Aug 2017, In : PLOS ONE. 12, 8, 13 p., 0182297.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effect of warmth acclimation on behaviour, thermophysiology and perception

Pallubinsky, H., Kingma, B. R. M., Schellen, L., Dautzenberg, B., van Baak, M. A. & Lichtenbelt, W. D. V. M., 2017, In : Building Research and Information. 45, 7, p. 800-807 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The impact of morning light intensity and environmental temperature on body temperatures and alertness

te Kulve, M., Schlangen, L. J. M., Schellen, L., Frijns, A. J. H. & Lichtenbelt, W. D. V. M., 1 Jun 2017, In : Physiology & Behavior. 175, p. 72-81 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport

Bartelt, A., John, C., Schaltenberg, N., Berbee, J. F. P., Worthmann, A., Cherradi, M. L., Schlein, C., Piepenburg, J., Boon, M. R., Rinninger, F., Heine, M., Toedter, K., Niemeier, A., Nilsson, S. K., Fischer, M., Wijers, S. L., Lichtenbelt, W. V. M., Scheja, L., Rensen, P. C. N. & Heeren, J., 19 Apr 2017, In : Nature Communications. 8, 10 p., 15010.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Thermophysiological adaptations to passive mild heat acclimation

Pallubinsky, H., Schellen, L., Kingma, B. R. M., Dautzenberg, B., van Baak, M. A. & van Marken Lichtenbelt, W. D., Mar 2017, In : Temperature. 4, 2, p. 176-186 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016
6 Citations (Scopus)

Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans

Chen, K. Y., Cypess, A. M., Laughlin, M. R., Haft, C. R., Hu, H. H., Bredella, M. A., Enerback, S., Kinahan, P. E., Lichtenbelt, W. V. M., Lin, F. I., Sunderland, J. J., Virtanen, K. A. & Wahl, R. L., 9 Aug 2016, In : Cell Metabolism. 24, 2, p. 210-222

Research output: Contribution to journalArticleAcademicpeer-review

Brown Adipose Tissue: A Human Perspective

Boon, M. R. & van Marken Lichtenbelt, W. D., 1 Jan 2016, Handbook of Experimental Pharmacology. Springer, Vol. 233. p. 301-319

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

1 Citation (Scopus)

Combatting type 2 diabetes by turning up the heat

Schrauwen, P. & van Marken Lichtenbelt, W., Nov 2016, In : Diabetologia. 59, 11, p. 2269-2279

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity

Chen, Y., Buyel, J. J., Hanssen, M. J. W., Siegel, F., Pan, R., Naumann, J., Schell, M., van der Lans, A., Schlein, C., Froehlich, H., Heeren, J., Virtanen, K. A., Lichtenbelt, W. V. M. & Pfeifer, A., Apr 2016, In : Nature Communications. 7, 11420.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Human whole body cold adaptation

Daanen, H. A. & van Marken Lichtenbelt, W., 2016, In : Temperature. 3, 1, p. 104-118

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)

Local cooling in a warm environment

Pallubinsky, H., Schellen, L., Rieswijk, T. A., Breukel, C. M. G. A. M., Kingma, B. R. M. & Lichtenbelt, W. D. V. M., 1 Feb 2016, In : Energy and Buildings. 113, p. 15-22

Research output: Contribution to journalArticleAcademicpeer-review

Thyroid Hormone Activates Brown Adipose Tissue and Increases Non-Shivering Thermogenesis - A Cohort Study in a Group of Thyroid Carcinoma Patients

Broeders, E., Vijgen, G., Havekes, B., Bouvy, N. D., Mottaghy, F. M., Kars, M., Schaper, N. C., Schrauwen, P., Brans, B. & van Marken Lichtenbelt, W., 19 Jan 2016, In : PLOS ONE. 11, 1, 15 p., e0145049.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015
15 Citations (Scopus)

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

Dijk, W., Heine, M., Vergnes, L., Boon, M. R., Schaart, G., Hesselink, M., Reue, K., van Marken Lichtenbelt, W., Olivecrona, G., Rensen, P. C., Heeren, J. & Kersten, S., 17 Oct 2015, In : Elife. 4, 23 p., e08428.

Research output: Contribution to journalArticleAcademicpeer-review

Cold acclimation affects immune composition in skeletal muscle of healthy lean subjects

van der Lans, A. A. J., Boon, M. R., Haks, M. C., Quinten, E., Schaart, G., Ottenhoff, T. H. & van Marken Lichtenbelt, W., 1 Jan 2015, In : Physiological Reports. 3, 7, e12394.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Endogenous ways to stimulate brown adipose tissue in humans

Broeders, E., Bouvy, N. D. & van Marken Lichtenbelt, W. D., 1 Jan 2015, In : Annals of Medicine. 47, 2, p. 123-132

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Energy consumption in buildings and female thermal demand

Kingma, B. & van Marken Lichtenbelt, W., Dec 2015, In : Nature Climate Change. 5, 12, p. 1054-1056 5 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

16 Citations (Scopus)

Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance.

Hanssen, M. J., Wierts, R., Hoeks, J., Gemmink, A., Brans, B., Mottaghy, F. M., Schrauwen, P. & van Marken Lichtenbelt, W. D., Mar 2015, In : Diabetologia. 58, 3, p. 586-595 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Impact of bariatric surgery on carotid artery inflammation and the metabolic activity in different adipose tissues

Bucerius, J., Vijgen, G. H., Brans, B., Bouvy, N. D., Bauwens, M., Rudd, J. H., Havekes, B., Fayad, Z. A., van Marken Lichtenbelt, W. D. & Mottaghy, F. M., May 2015, In : Medicine. 94, 20, 9 p., e725.

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Low brown adipose tissue activity in endurance-trained compared with lean sedentary men

Vosselman, M. J., Hoeks, J., Brans, B., Pallubinsky, H., Nascimento, E. B. M., van der Lans, A. A. J., Broeders, E. P., Mottaghy, F. M., Schrauwen, P. & van Marken Lichtenbelt, W. D., Dec 2015, In : International Journal of Obesity. 39, 12, p. 1696-1702 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Serum FGF21 levels are associated with brown adipose tissue activity in humans

Hanssen, M., Broeders, E., Samms, R. J., Vosselman, M. J., van der Lans, A. A., Cheng, C. C., Adams, A. C., van Marken Lichtenbelt, W. D. & Schrauwen, P., 1 Jan 2015, In : Scientific Reports. 5, 10275.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
40 Citations (Scopus)

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

Hanssen, M. J., Hoeks, J., Brans, B., van der Lans, A. A., Schaart, G., van den Driessche, J. J., Jorgensen, J. A., Boekschoten, M. V., Hesselink, M. K., Havekes, B., Kersten, S., Mottaghy, F. M., van Marken Lichtenbelt, W. D. & Schrauwen, P., Aug 2015, In : Nature Medicine. 21, 8, p. 863-865 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

Broeders, E. P., Nascimento, E. B. M., Havekes, B., Brans, B., Roumans, K. H. M., Tailleux, A., Schaart, G., Kouach, M., Charton, J., Deprez, B., Bouvy, N. D., Mottaghy, F., Staels, B., van Marken Lichtenbelt, W. & Schrauwen, P., 1 Sep 2015, In : Cell Metabolism. 22, 3, p. 418-426 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

The future of brown adipose tissues in the treatment of type 2 diabetes

Schrauwen, P., van Marken Lichtenbelt, W. D. & Spiegelman, B. M., Aug 2015, In : Diabetologia. 58, 8, p. 1704-1707 4 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

2014

Beyond the classic thermoneutral zone

Kingma, B. R. M., Frijns, A. J. H., Schellen, L. & van Marken Lichtenbelt, W. D., 1 Jan 2014, In : Temperature. 1, 2, p. 142-149

Research output: Contribution to journalArticleAcademic

39 Citations (Scopus)

Brown adipose tissue volume in healthy lean south Asian adults compared with white Caucasians: a prospective, case-controlled observational study

Bakker, L. E., Boon, M. R., van der Linden, R. A., Arias-Bouda, L. P., van Klinken, J. B., Smit, F., Verberne, H. J., Jukema, J. W., Tamsma, J. T., Havekes, L. M., van Marken Lichtenbelt, W. D., Jazet, I. M. & Rensen, P. C., 1 Jan 2014, In : The Lancet Diabetes & Endocrinology. 2, 3, p. 210-217

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)

Cold-activated brown adipose tissue in human adults: methodological issues

van der Lans, A. A., Wierts, R., Vosselman, M. J., Schrauwen, P., Brans, B. & van Marken Lichtenbelt, W. D., 15 Jul 2014, In : American Journal of Physiology-regulatory Integrative and Comparative Physiology. 307, 2, p. R103-R113 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fat cells gain new identities

Nascimento, E. B. M., Boon, M. R. & van Marken Lichtenbelt, W. D., 30 Jul 2014, In : Science Translational Medicine. 6, 247, 3 p., 247fs229.

Research output: Contribution to journalEditorialAcademicpeer-review