Twan van den Beucken

Research output

Research output per year 2008 2011 2014 2016 2017 2019 2023

• 25 Article
• 2 (Systematic) Review article
• 1 Conference Abstract/Poster in journal
• 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• Article

  A cross-omics approach to investigate temporal gene expression regulation by 5-hydroxymethylcytosine via TBH-derived oxidative stress showed involvement of different regulatory kinases

  Briede, J. J., Deferme, L., Wolters, J. E. J., Claessen, S. M. H., van den Beucken, T., Wagner, R. J., van Breda, S. G. & Kleinjans, J. C. S., 1 Apr 2018, In: Toxicology in Vitro. 48, p. 318-328 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Cell surface profiling using high-throughput flow cytometry: a platform for biomarker discovery and analysis of cellular heterogeneity

  Gedye, C. A., Hussain, A., Paterson, J., Smrke, A., Saini, H., Sirskyj, D., Pereira, K., Lobo, N., Stewart, J., Go, C., Ho, J., Medrano, M., Hyatt, E., Yuan, J., Lauriault, S., Meyer, M., Kondratyev, M., van den Beucken, T., Jewett, M., Dirks, P., & 7 othersGuidos, C. J., Danska, J., Wang, J., Wouters, B., Neel, B., Rottapel, R. & Ailles, L. E., 2014, In: PLOS ONE. 9, 8, e105602.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Cigarette Smoke Extract Induces a Phenotypic Shift in Epithelial Cells; Involvement of HIF1α in Mesenchymal Transition

  Eurlings, I. M. J., Reynaert, N. L., van den Beucken, T., Gosker, H. R., de Theije, C. C., Verhamme, F. M., Bracke, K. R., Wouters, E. F. M. & Dentener, M. A., 16 Oct 2014, In: PLOS ONE. 9, 10, 11 p., e107757.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

  Rouschop, K. M. A., Dubois, L., Schaaf, M. B. E., van den Beucken, T., Lieuwes, N., Keulers, T. G. H., Savelkouls, K. G. M., Bussink, J., van der Kogel, A. J., Koritzinsky, M. & Wouters, B. G., Jun 2011, In: Radiotherapy and Oncology. 99, 3, p. 385-391

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  42 Downloads (Pure)

• Dynamic Interplay between the Transcriptome and Methylome in Response to Oxidative and Alkylating Stress

  Deferme, L., Wolters, J. E. J., Claessen, S. M. H., Theunissen, D., van den Beucken, T., Wagner, J. R., van Breda, S. G., Kleinjans, J. C. S. & Briede, J. J., Sept 2016, In: Chemical Research in Toxicology. 29, 9, p. 1428-1438

  Research output: Contribution to journal › Article › Academic › peer-review

• Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T

  Ramaekers, C. H. M. A., van den Beucken, T., Meng, A., Kassam, S., Thoms, J., Bristow, R. G. & Wouters, B. G., Oct 2011, In: Radiotherapy and Oncology. 101, 1, p. 190-197

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3

  Prickaerts, P., Adriaens, M. E., van den Beucken, T., Koch, E., Dubois, L., Dahlmans, V. E. H., Gits, C., Evelo, C. T. A., Chan-Seng-Yue, M., Wouters, B. G. & Voncken, J. W., 26 Oct 2016, In: Epigenetics & Chromatin. 9, 19 p., 46.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

  Rupaimoole, R., Wu, S. Y., Pradeep, S., Ivan, C., Pecot, C. V., Gharpure, K. M., Nagaraja, A. S., Armaiz-Pena, G. N., McGuire, M., Zand, B., Dalton, H. J., Filant, J., Miller, J. B., Lu, C., Sadaoui, N. C., Mangala, L. S., Taylor, M., van den Beucken, T., Koch, E., Rodriguez-Aguayo, C., & 9 othersHuang, L., Bar-Eli, M., Wouters, B. G., Radovich, M., Ivan, M., Calin, G. A., Zhang, W., Lopez-Berestein, G. & Sood, A. K., 2014, In: Nature Communications. 5, 5202.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

  van den Beucken, T., Koch, E., Chu, K., Rupaimoole, R., Prickaerts, P., Adriaens, M., Voncken, J. W., Harris, A. L., Buffa, F. M., Haider, S., Starmans, M. H., Yao, C. Q., Ivan, M., Ivan, C., Pecot, C. V., Boutros, P. C., Sood, A. K., Koritzinsky, M. & Wouters, B. G., 2014, In: Nature Communications. 5, p. 5203 1 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Identification of essential transcription factors for adequate DNA damage response after benzo(a)pyrene and aflatoxin B1 exposure by combining transcriptomics with functional genomics

  Smit, E., Souza, T., Jennen, D. G. J., Kleinjans, J. C. S. & van den Beucken, T., 1 Sept 2017, In: Toxicology. 390, p. 74-82 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Inferring transcription factor activity from microarray data reveals novel targets for toxicological investigations

  Souza, T. M., van den Beucken, T., Kleinjans, J. C. S. & Jennen, D. G. J., 15 Aug 2017, In: Toxicology. 389, p. 101-107 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• In vivo optical imaging of MMP2 immuno protein antibody: tumor uptake is associated with MMP2 activity

  Panth, K. M., van den Beucken, T., Biemans, R., Lieuwes, N. G., Weber, M., Losen, M., Yaromina, A., Dubois, L. J. & Lambin, P., 29 Feb 2016, In: Scientific Reports. 6, 22198.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• IsoTools: a flexible workflow for long-read transcriptome sequencing analysis

  Lienhard, M., van den Beucken, T., Timmermann, B., Hochradel, M., Boerno, S., Caiment, F., Vingron, M. & Herwig, R., 1 Jun 2023, In: Bioinformatics. 39, 6, 10 p., btad364.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• PERK/eIF2 alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

  Rouschop, K. M., Dubois, L. J., Keulers, T. G., van den Beucken, T., Lambin, P., Bussink, J., van der Kogel, A. J., Koritzinsky, M. & Wouters, B. G., 19 Mar 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 12, p. 4622-4627

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  37 Downloads (Pure)

• Persistent transcriptional responses show the involvement of feed-forward control in a repeated dose toxicity study

  de Souza, T., Rieswijk, L., van den Beucken, T., Kleinjans, J. & Jennen, D., 15 Jan 2017, In: Toxicology. 375, p. 58-63

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  55 Downloads (Pure)

• Phosphorylation of eIF2α promotes cell survival in response to benzo[a]pyrene exposure

  Smit, E., Kleinjans, J. C. S. & van den Beucken, T., Feb 2019, In: Toxicology in Vitro. 54, p. 330-337 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia

  Adriaens, M. E., Prickaerts, P., Chan-Seng-Yue, M., van den Beucken, T., Dahlmans, V. E. H., Eijssen, L. M., Beck, T., Wouters, B. G., Voncken, W. & Evelo, C. T. A., 1 Nov 2016, In: Epigenetics & Chromatin. 9, 48.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Radioprotective effects of ATP in human blood ex vivo.

  Swennen, E. L., Dagnelie, P. C., van den Beucken, A. M. & Bast, A., 1 Jan 2008, In: Biochemical and Biophysical Research Communications. 367, 2, p. 383-387

  Research output: Contribution to journal › Article › Academic › peer-review

• Regulation of TRIB3 mRNA and Protein in Breast Cancer

  Wennemers, M., Bussink, J., van den Beucken, T., Sweep, F. C. G. J. & Span, P. N., 20 Nov 2012, In: PLOS ONE. 7, 11, e49439.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• RNF8-Independent Lys63 Poly-Ubiquitylation Prevents Genomic Instability in Response to Replication-Associated DNA Damage

  Ramaekers, C. H. M. A., van den Beucken, T., Bristow, R. G., Chiu, R. K., Durocher, D. & Wouters, B. G., 28 Feb 2014, In: PLOS ONE. 9, 2, e89997.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

  Rouschop, K. M. A., van den Beucken, T., Dubois, L., Niessen, H., Bussink, J., Savelkouls, K., Keulers, T., Mujcic, H., Landuyt, W., Voncken, J. W., Lambin, P., van der Kogel, A. J., Koritzinsky, M. & Wouters, B. G., Jan 2010, In: Journal of Clinical Investigation. 120, 1, p. 127-141

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  35 Downloads (Pure)

• Translational control is a major contributor to hypoxia induced gene expression

  van den Beucken, T., Magagnin, M. G., Jutten, B., Seigneuric, R., Lambin, P., Koritzinsky, M. & Wouters, B. G., Jun 2011, In: Radiotherapy and Oncology. 99, 3, p. 379-384

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  38 Downloads (Pure)

• Translational regulation is a key determinant of the cellular response to benzo[a]pyrene

  Smit, E., Caiment, F., Piepers, J., Kleinjans, J. C. S. & van den Beucken, T., 1 Oct 2018, In: Toxicology Letters. 295, p. 144-152 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Two phases of disulfide bond formation have differing requirements for oxygen

  Koritzinsky, M., Levitin, F., van den Beucken, T., Rumantir, R. A., Harding, N. J., Chu, K. C., Boutros, P. C., Braakman, I. & Wouters, B. G., 25 Nov 2013, In: Journal of Cell Biology. 203, 4, p. 615-627

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Valproic acid promotes mitochondrial dysfunction in primary human hepatocytes in vitro; impact of C/EBPα-controlled gene expression

  Caiment, F., Wolters, J., Smit, E., Schrooders, Y., Kleinjans, J. & van den Beucken, T., 1 Oct 2020, In: Archives of Toxicology. 94, 10, p. 3463-3473 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access