20082019
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Research Output 2008 2019

  • 23 Article
  • 1 Conference Abstract/Poster in journal
  • 1 Doctoral Thesis
2019

Identification of key transcription factor networks mediating valproic acid-induced mitochondrial dysfunctioning in primary human hepatocytes

Caiment, F., Wolters, J., Smit, E., Schrooders, Y., Kleinjans, J. C. S. & van den Beucken, T., 15 Oct 2019, In : Toxicology Letters. 314, p. S162-S162 1 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Phosphorylation of eIF2 alpha promotes cell survival in response to benzo[a]pyrene exposure

Smit, E., Kleinjans, J. C. S. & van den Beucken, T., Feb 2019, In : Toxicology in Vitro. 54, p. 330-337 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Translational regulation is a key determinant of the cellular response to benzo[a]pyrene

Smit, E., Caiment, F., Piepers, J., Kleinjans, J. C. S. & van den Beucken, T., 1 Oct 2018, In : Toxicology Letters. 295, p. 144-152 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Inferring transcription factor activity from microarray data reveals novel targets for toxicological investigations

Souza, T. M., van den Beucken, T., Kleinjans, J. C. S. & Jennen, D. G. J., 15 Aug 2017, In : Toxicology. 389, p. 101-107 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016
1 Citation (Scopus)
3 Citations (Scopus)

Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3

Adriaens, M. E., Prickaerts, P., Beucken, T. V. D., Koch, E., Dubois, L., Dahlmans, V. E. H., Gits, C., Evelo, C. T. A., Chan-Seng-Yue, M., Wouters, B. G. & Voncken, W., 26 Oct 2016, In : Epigenetics & Chromatin. 9, p. 46 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

In vivo optical imaging of MMP2 immuno protein antibody: tumor uptake is associated with MMP2 activity

Panth, K. M., van den Beucken, T., Biemans, R., Lieuwes, N. G., Weber, M., Losen, M., Yaromina, A., Dubois, L. J. & Lambin, P., 29 Feb 2016, In : Scientific Reports. 6, 22198.

Research output: Contribution to journalArticleAcademicpeer-review

Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia

Adriaens, M. E., Prickaerts, P., Chan-Seng-Yue, M., van den Beucken, T., Dahlmans, V. E. H., Eijssen, L. M., Beck, T., Wouters, B. G., Voncken, W. & Evelo, C. T. A., 1 Nov 2016, In : Epigenetics & Chromatin. 9, 48.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2014
5 Citations (Scopus)

Cell surface profiling using high-throughput flow cytometry: a platform for biomarker discovery and analysis of cellular heterogeneity

Gedye, C. A., Hussain, A., Paterson, J., Smrke, A., Saini, H., Sirskyj, D., Pereira, K., Lobo, N., Stewart, J., Go, C., Ho, J., Medrano, M., Hyatt, E., Yuan, J., Lauriault, S., Meyer, M., Kondratyev, M., van den Beucken, T., Jewett, M., Dirks, P. & 7 others, Guidos, C. J., Danska, J., Wang, J., Wouters, B., Neel, B., Rottapel, R. & Ailles, L. E., 2014, In : PLOS ONE. 9, 8, e105602.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Cigarette Smoke Extract Induces a Phenotypic Shift in Epithelial Cells; Involvement of HIF1α in Mesenchymal Transition

Eurlings, I. M. J., Reynaert, N. L., van den Beucken, T., Gosker, H. R., de Theije, C. C., Verhamme, F. M., Bracke, K. R., Wouters, E. F. M. & Dentener, M. A., 16 Oct 2014, In : PLOS ONE. 9, 10, 11 p., e107757.

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

Rupaimoole, R., Wu, S. Y., Pradeep, S., Ivan, C., Pecot, C. V., Gharpure, K. M., Nagaraja, A. S., Armaiz-Pena, G. N., McGuire, M., Zand, B., Dalton, H. J., Filant, J., Miller, J. B., Lu, C., Sadaoui, N. C., Mangala, L. S., Taylor, M., van den Beucken, T., Koch, E., Rodriguez-Aguayo, C. & 9 others, Huang, L., Bar-Eli, M., Wouters, B. G., Radovich, M., Ivan, M., Calin, G. A., Zhang, W., Lopez-Berestein, G. & Sood, A. K., 2014, In : Nature Communications. 5, 5202.

Research output: Contribution to journalArticleAcademicpeer-review

50 Citations (Scopus)

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

van den Beucken, T., Koch, E., Chu, K., Rupaimoole, R., Prickaerts, P., Adriaens, M., Voncken, J. W., Harris, A. L., Buffa, F. M., Haider, S., Starmans, M. H., Yao, C. Q., Ivan, M., Ivan, C., Pecot, C. V., Boutros, P. C., Sood, A. K., Koritzinsky, M. & Wouters, B. G., 2014, In : Nature Communications. 5, p. 5203 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

RNF8-Independent Lys63 Poly-Ubiquitylation Prevents Genomic Instability in Response to Replication-Associated DNA Damage

Ramaekers, C. H. M. A., van den Beucken, T., Bristow, R. G., Chiu, R. K., Durocher, D. & Wouters, B. G., 28 Feb 2014, In : PLOS ONE. 9, 2, e89997.

Research output: Contribution to journalArticleAcademicpeer-review

2013
51 Citations (Scopus)
23 Citations (Scopus)

Two phases of disulfide bond formation have differing requirements for oxygen

Koritzinsky, M., Levitin, F., van den Beucken, T., Rumantir, R. A., Harding, N. J., Chu, K. C., Boutros, P. C., Braakman, I. & Wouters, B. G., 25 Nov 2013, In : Journal of Cell Biology. 203, 4, p. 615-627

Research output: Contribution to journalArticleAcademicpeer-review

2012

Regulation of TRIB3 mRNA and Protein in Breast Cancer

Wennemers, M., Bussink, J., van den Beucken, T., Sweep, F. C. G. J. & Span, P. N., 20 Nov 2012, In : PLOS ONE. 7, 11, e49439.

Research output: Contribution to journalArticleAcademicpeer-review

2011

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

Rouschop, K. M. A., Dubois, L., Schaaf, M. B. E., van den Beucken, T., Lieuwes, N., Keulers, T. G. H., Savelkouls, K. G. M., Bussink, J., van der Kogel, A. J., Koritzinsky, M. & Wouters, B. G., Jun 2011, In : Radiotherapy and Oncology. 99, 3, p. 385-391

Research output: Contribution to journalArticleAcademicpeer-review

Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T

Ramaekers, C. H. M. A., van den Beucken, T., Meng, A., Kassam, S., Thoms, J., Bristow, R. G. & Wouters, B. G., Oct 2011, In : Radiotherapy and Oncology. 101, 1, p. 190-197

Research output: Contribution to journalArticleAcademicpeer-review

Translational control is a major contributor to hypoxia induced gene expression

van den Beucken, T., Magagnin, M. G., Jutten, B., Seigneuric, R., Lambin, P., Koritzinsky, M. & Wouters, B. G., Jun 2011, In : Radiotherapy and Oncology. 99, 3, p. 379-384

Research output: Contribution to journalArticleAcademicpeer-review

2010

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

Rouschop, K. M. A., van den Beucken, T., Dubois, L., Niessen, H., Bussink, J., Savelkouls, K., Keulers, T., Mujcic, H., Landuyt, W., Voncken, J. W., Lambin, P., van der Kogel, A. J., Koritzinsky, M. & Wouters, B. G., Jan 2010, In : Journal of Clinical Investigation. 120, 1, p. 127-141

Research output: Contribution to journalArticleAcademicpeer-review

2008
14 Citations (Scopus)

Radioprotective effects of ATP in human blood ex vivo.

Swennen, E. L., Dagnelie, P. C., van den Beucken, A. M. & Bast, A., 1 Jan 2008, In : Biochemical and Biophysical Research Communications. 367, 2, p. 383-387

Research output: Contribution to journalArticleAcademicpeer-review

184 Downloads (Pure)
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