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Research Output 2015 2019

2019

Hematopoietic Npc1 mutation shifts gut microbiota composition in Ldlr(-/-) mice on a high-fat, high-cholesterol diet

Houben, T., Penders, J., Oligschlaeger, Y., dos Reis, I. A. M., Bonder, M-J., Koonen, D. P., Fu, J., Hofker, M. H. & Shiri-Sverdlov, R., 18 Oct 2019, In : Scientific Reports. 9, 11 p., 14956.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Inflammatory Bowel Disease: A Stressed "Gut/Feeling"

Oligschlaeger, Y., Yadati, T., Houben, T., Olivan, C. M. C. & Shiri-Sverdlov, R., Jul 2019, In : Cells. 8, 7, p. 1-26 26 p., 659.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Inhibiting Extracellular Cathepsin D Reduces Hepatic Steatosis in Sprague-Dawley Rats

Khurana, P., Yadati, T., Goyal, S., Dolas, A., Houben, T., Oligschlaeger, Y., Agarwal, A. K., Kulkarni, A. & Shiri-Sverdlov, R., May 2019, In : Biomolecules. 9, 5, 12 p., 171.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pneumococcal Immunization Reduces Neurological and Hepatic Symptoms in a Mouse Model for Niemann-Pick Type C1 Disease

Houben, T., dos Reis, I. M., Oligschlaeger, Y., Steinbusch, H., Gijbels, M. J. J., Hendrikx, T., Binder, C. J., Cassiman, D., Westerterp, M., Prickaerts, J. & Shiri-Sverdlov, R., 7 Jan 2019, In : Frontiers in Immunology. 9, p. 1-13 13 p., 3089.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Comment on Tauriainen et al. Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD

Plat, J., Baumgartner, S., Houben, T., Vreugdenhil, A. C. E., Mensink, R. P., Luetjohann, D. & Shiri-Sverdlov, R., 31 Oct 2018, In : Bioscience Reports. 38, 2 p., 20180505.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Exogenously Added Oxyphytosterols Do Not Affect Macrophage-Mediated Inflammatory Responses

Oligschlaeger, Y., Houben, T., Jeurissen, M. L. J., Bitorina, A. V., Konings, M., Baumgartner, S., Plat, J. & Shiri-Sverdlov, R., Apr 2018, In : Lipids. 53, 4, p. 457-462 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
225 Downloads (Pure)

Lysosomes ‘in control’: where lipids meet Inflammation in metabolic syndrome

Houben, T., 2018, Maastricht: Maastricht University. 245 p.

Research output: ThesisDoctoral ThesisInternal

Open Access
File
2017

Blood-derived macrophages prone to accumulate lysosomal lipids trigger oxLDL-dependent murine hepatic inflammation

Houben, T., Oligschlaeger, Y., Bitorina, A. V., Hendrikx, T., Walenbergh, S. M. A., Lenders, M-H., Gijbels, M. J. J., Verheyen, F., Luetjohann, D., Hofker, M. H., Binder, C. J. & Shiri-Sverdlov, R., 2 Oct 2017, In : Scientific Reports. 7, 9 p., 12550.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cathepsin D regulates lipid metabolism in murine steatohepatitis

Houben, T., Oligschlaeger, Y., Hendrikx, T., Bitorina, A. V., Walenbergh, S. M. A., van Gorp, P. J., Gijbels, M. J. J., Friedrichs, S., Plat, J., Schaap, F. G., Luetjohann, D., Hofker, M. H. & Shiri-Sverdlov, R., 14 Jun 2017, In : Scientific Reports. 7, 10 p., 3494.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids

Janssen, A. W. F., Houben, T., Katiraei, S., Dijk, W., Boutens, L., van der Bolt, N., Wang, Z., Brown, J. M., Hazen, S. L., Mandard, S., Shiri-Sverdlov, R., Kuipers, F., van Dijk, K. W., Vervoort, J., Stienstra, R., Hooiveld, G. J. E. J. & Kersten, S., Jul 2017, In : Journal of Lipid Research. 58, 7, p. 1399-1416 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Oxidized LDL at the crossroads of immunity in non-alcoholic steatohepatitis

Houben, T., Brandsma, E., Walenbergh, S. M. A., Hofker, M. H. & Shiri-Sverdlov, R., Apr 2017, In : Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids. 1862, 4, p. 416-429 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2016
2 Citations (Scopus)

Macrophage Stimulating Protein Enhances Hepatic Inflammation in alpha NASH Model

Li, J., Chanda, D., van Gorp, P., Jeurissen, M. L. J., Houben, T., Walenbergh, S. M. A., Debets, J., Oligschläger, Y., Gijbels, M. J. J., Neumann, D. & Shiri-Sverdlov, R., 29 Sep 2016, In : PLOS ONE. 11, 9, e0163843.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis

Chanda, D., Li, J., Oligschläger, Y., Jeurissen, M. L. J., Houben, T., Walenbergh, S. M. A., Shiri-Sverdlov, R. & Neumann, D., Sep 2016, In : Experimental and Molecular Medicine. 48, e258.

Research output: Contribution to journalArticleAcademicpeer-review

Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in LdIr(-/-) Mice

Jeurissen, M. L. J., Walenbergh, S. M. A., Houben, T., Hendrikx, T., Li, J., Oligschläger, Y., van Gorp, P. J., Gijbels, M. J. J., Bitorina, A., Nessel, I., Radtke, F., Vooijs, M., Theys, J. & Shiri-Sverdlov, R., 29 Nov 2016, In : PLOS ONE. 11, 11, e0167199.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention

Walenbergh, S. M. A., Houben, T., Rensen, S. S., Bieghs, V., Hendrikx, T., van Gorp, P. J., Oligschläger, Y., Jeurissen, M. L. J., Gijbels, M. J. J., Buurman, W. A., Vreugdenhil, A. C. E., Greve, J. W. M., Plat, J., Hofker, M. H., Kalhan, S., Pihlajamaki, J., Lindsey, P., Koek, G. H. & Shiri-Sverdlov, R., 6 Dec 2016, In : Scientific Reports. 6, 38278.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr(-/-) mice

Jeurissen, M. L. J., Walenbergh, S. M. A., Houben, T., Gijbels, M. J. J., Li, J., Hendrikx, T., Oligschläger, Y., van Gorp, P. J., Binder, C. J., Donners, M. M. P. C. & Shiri-Sverdlov, R., Dec 2016, In : Atherosclerosis. 255, p. 59-65

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015
5 Citations (Scopus)

Bone marrow-specific caspase-1/11 deficiency inhibits atherosclerosis development in Ldlr(-/-) mice

Hendrikx, T., Jeurissen, M. L. J., van Gorp, P. J., Gijbels, M. J., Walenbergh, S. M. A., Houben, T., van Gorp, R., Pottgens, C. C., Stienstra, R., Netea, M. G., Hofker, M., Donners, M. M. & Shiri-Sverdlov, R., 1 Jan 2015, In : FEBS Journal. 282, 12, p. 2327-2338

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr(-/-) mice

Hendrikx, T., Jeurissen, M. L. J., Bieghs, V., Walenbergh, S. M. A., van Gorp, P. J., Verheyen, F., Houben, T., Guichot, Y. D., Gijbels, M. J., Leitersdorf, E., Hofker, M. H., Luetjohann, D. & Shiri-Sverdlov, R., Feb 2015, In : Journal of Hepatology. 62, 2, p. 430-436 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Plasma cathepsin d levels: a novel tool to predict pediatric hepatic inflammation

Walenbergh, S. M., Houben, T., Hendrikx, T., Jeurissen, M. L. J., van Gorp, P. J., Vreugdenhil, A. C., Adriaanse, M., Buurman, W., Hofker, M., Mosca, A., Lindsey, P. J., Alisi, A., Liccardo, D., Panera, N., Koek, G. H., Nobili, V. & Shiri-Sverdlov, R., 1 Jan 2015, In : American Journal of Gastroenterology. 110, 3, p. 462-470

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Plasma IL-1 receptor antagonist levels correlate with the development of non-alcoholic steatohepatitis

Hendrikx, T., Walenbergh, S. M., Jeurissen, M., Houben, T., van Gorp, P. J., Lindsey, P. J., Koek, G. H., Kalhan, S., Pihlajamaki, J., Hofker, M. H. & Shiri-Sverdlov, R., 1 Jan 2015, In : Biomarkers in Medicine. 9, 12, p. 1301-1309 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

The immunity-diet-microbiota axis in the development of metabolic syndrome

Brandsma, E., Houben, T., Fu, J., Shiri-Sverdlov, R. & Hofker, M., Apr 2015, In : Current Opinion in Lipidology. 26, 2, p. 73-81 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Weekly Treatment of 2-Hydroxypropyl-beta-cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice

Walenbergh, S. M., Houben, T., Hendrikx, T., Jeurissen, M. L., van Gorp, P. J. J., Vaes, N., Olde Damink, S. W. M., Verheyen, F., Koek, G. H., Lutjohann, D., Grebe, A., Latz, E. & Shiri-Sverdlov, R., Sep 2015, In : International journal of molecular sciences. 16, 9, p. 21056-21069 14 p.

Research output: Contribution to journalArticleAcademicpeer-review