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Tim Welting

20102019

Research output per year

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Research Output

2019

Hypomorphic mutations of TRIP11 cause odontochondrodysplasia

Wehrle, A., Witkos, T. M., Unger, S., Schneider, J., Follit, J. A., Hermann, J., Welting, T., Fano, V., Hietala, M., Vatanavicharn, N., Schoner, K., Spranger, J., Schmidts, M., Zabel, B., Pazour, G. J., Bloch-Zupan, A., Nishimura, G., Superti-Furga, A., Lowe, M. & Lausch, E., 7 Feb 2019, In : JCI INSIGHT. 4, 3, p. 1-23 23 p., 124701.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Increased TGF-β and BMP Levels and Improved Chondrocyte-Specific Marker Expression In Vitro under Cartilage-Specific Physiological Osmolarity

Timur, U. T., Caron, M., van den Akker, G., van der Windt, A., Visser, J., van Rhijn, L., Weinans, H., Welting, T., Emans, P. & Jahr, H., 2 Feb 2019, In : International journal of molecular sciences. 20, 4, 15 p., 795.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Multicentric osteolytic syndromes represent a phenotypic spectrum defined by defective collagen remodeling

de Vos, I. J. H. M., Wong, A. S. W., Welting, T. J. M., Coull, B. J. & van Steensel, M. A. M., Aug 2019, In : American Journal of Medical Genetics Part A. 179, 8, p. 1652-1664 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The antiviral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion

Steinbusch, M. M. F., Caron, M. M. J., Surtel, D. A. M., van den Akker, G. G. H., van Dijk, P. J., Friedrich, F., Zabel, B., van Rhijn, L. W., Peffers, M. J. & Welting, T. J. M., 29 Mar 2019, In : Journal of Biological Chemistry. 294, 13, p. 5121-5136 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Celecoxib-mediated reduction of prostanoid release in Hoffa's fat pad from donors with cartilage pathology results in an attenuated inflammatory phenotype

Timur, U. T., Caron, M. M. J., Bastiaansen-Jenniskens, Y. M., Welting, T. J. M., van Rhijn, L. W., van Osch, G. J. V. M. & Emans, P. J., 1 May 2018, In : Osteoarthritis and Cartilage. 26, 5, p. 697-706 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

H-1 NMR Metabolomics Identifies Underlying Inflammatory Pathology in Osteoarthritis and Rheumatoid Arthritis Synovial Joints

Anderson, J. R., Chokesuwattanaskul, S., Phelan, M. M., Welting, T. J. M., Lim, L-Y., Peffers, M. J. & Wright, H. L., 1 Nov 2018, In : Journal of Proteome Research. 17, 11, p. 3780-3790 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling

Willems, B. A., Furmanik, M., Caron, M. M. J., Chatrou, M. L. L., Kusters, D. H. M., Welting, T. J. M., Stock, M., Rafael, M. S., Viegas, C. S. B., Simes, D. C., Vermeer, C., Reutelingsperger, C. P. M. & Schurgers, L. J., 21 Mar 2018, In : Scientific Reports. 8, 11 p., 4961.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Dysplasia epiphysealis hemimelica: a histological comparative study with osteochondromas

Stevens, J., Welting, T. J. M., Witlox, A. M., van Rhijn, L. W. & Staal, H. M., Jun 2017, In : Journal of Children's Orthopaedics. 11, 3, p. 160-168 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation

Steinbusch, M. M. F., Caron, M. M. J., Surtel, D. A. M., Friedrich, F., Lausch, E., Pruijn, G. J. M., Verhesen, W., Schroen, B. L. M., van Rhijn, L. W., Zabel, B. & Welting, T. J. M., 25 Jul 2017, In : Scientific Reports. 7, 15 p., 6440.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

MicroRNA Profiling in Cartilage Ageing

Balaskas, P., Goljanek-Whysall, K., Clegg, P., Fang, Y., Cremers, A., Emans, P., Welting, T. & Peffers, M., 2017, In : International Journal of Genomics. 2017, 11 p., 2713725.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

PRC1 Prevents Replication Stress during Chondrogenic Transit Amplification

Spaapen, F., Eijssen, L., Adriaens, M., Welting, T., Prickaerts, P., Salvaing, J., Dahlmans, V. E. H., Surtel, D., Kruitz, F., Kuijer, R., Takihara, Y., Marks, H., Stunnenberg, H., Wouters, B., Vidal, M. & Voncken, J., Dec 2017, In : Epigenomes. 1, 3, 31 p., 22.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis

Steinbusch, M. M. F., Fang, Y., Milner, P. I., Clegg, P. D., Young, D. A., Welting, T. J. M. & Peffers, M. J., 2 Mar 2017, In : Scientific Reports. 7, 11 p., 43558.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Celecoxib-loaded PEA microspheres as an auto regulatory drug-delivery system after intra-articular injection

Janssen, M., Timur, U. T., Woike, N., Welting, T. J. M., Draaisma, G., Gijbels, M., van Rhijn, L. W., Mihov, G., Thies, J. & Emans, P. J., 28 Dec 2016, In : Journal of Controlled Release. 244, p. 30-40

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

EGR1 controls divergent cellular responses of distinctive nucleus pulposus cell types

van den Akker, G. G. H., Surtel, D. A. M., Cremers, A., Hoes, M. F. G. A., Caron, M. M., Richardson, S. M., Rodrigues-Pinto, R., van Rhijn, L. W., Hoyland, J. A., Welting, T. J. M. & Voncken, J. W., 14 Mar 2016, In : BMC Musculoskeletal Disorders. 17, 124.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Experimental models in orthopedic infection research

Odekerken, J. C., Welting, T. J., Walenkamp, G. H. & Arts, J. J., 2016, Management of Periprosthetic Joint Infections (PJIs). Arts, J. J. C. & Geurts, J. (eds.). 1 ed. Woodhead Publishing, p. 81-116

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Novel Immortal Cell Lines Support Cellular Heterogeneity in the Human Annulus Fibrosus

van den Akker, G. G. H., Surtel, D. A. M., Cremers, A., Richardson, S. M., Hoyland, J. A., van Rhijn, L. W., Voncken, J. W. & Welting, T. J. M., 21 Jan 2016, In : PLOS ONE. 11, 1, e0144497.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

The Role of Prostaglandins and COX-Enzymes in Chondrogenic Differentiation of ATDC5 Progenitor Cells

Caron, M. M. J., Emans, P. J., Sanen, K., Surtel, D., Cremers, A., Ophelders, D., van Rhijn, L. W. & Welting, T. J. M., 6 Apr 2016, In : PLOS ONE. 11, 4, e0153162.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

UHMWPE Sublaminar Wires in Posterior Spinal Instrumentation Stability and Biocompatibility Assessment in an Ovine Pilot Study

Bogie, R., Voss, L., Arts, J. J., Lataster, A., Willems, P. C., Brans, B., van Rhijn, L. W. & Welting, T. J. M., Dec 2016, In : CLINICAL SPINE SURGERY. 29, 10, p. E542-E549

Research output: Contribution to journalArticleAcademicpeer-review

2015

BAPX-1/NKX-3.2 Acts as a Chondrocyte Hypertrophy Molecular Switch in Osteoarthritis

Caron, M. M. J., Emans, P. J., Surtel, D. A. M., van der Kraan, P. M., van Rhijn, L. W. & Welting, T. J. M., Nov 2015, In : Arthritis & Rheumatology. 67, 11, p. 2944-2956 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

ELISA-based detection of gentamicin and vancomycin in protein-containing samples

Odekerken, J. C. E., Logister, D. M. W., Assabre, L., Arts, J. J. C., Walenkamp, G. H. I. M. & Welting, T. J. M., 15 Oct 2015, In : SpringerPlus. 4, 8 p., 614.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Influence of the Molecular Weight and Charge of Antibiotics on Their Release Kinetics From Gelatin Nanospheres

Song, J., Odekerken, J. C. E., Löwik, D. W. P. M., López-Pérez, P. M., Welting, T. J. M., Yang, F., Jansen, J. A. & Leeuwenburgh, S. C. G., 1 Jan 2015, In : Macromolecular Bioscience. 15, 7, p. 901-911

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Mechanics and biology in intervertebral disc degeneration: a vicious circle

Vergroesen, P. -P. A., Kingma, I., Emanuel, K. S., Hoogendoorn, R. J. W., Welting, T. J., van Royen, B. J., van Dieen, J. H. & Smit, T. H., Jul 2015, In : Osteoarthritis and Cartilage. 23, 7, p. 1057-1070

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)

The Microarchitecture of Bone in Osteochondromas, A Pilot Study With Micro Computed Tomography Imaging

Staal, H., Nijhuis, W., Witlox, M. A., Boom, K. R. J., Paffen, G., Ham, S. J., Welting, T., van Rietbergen, B. & van Rhijn, L., 2015, In : Journal of Bone Reports & Recommendations. 1, 2, 10.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2014

(18)F-FDG microPET imaging differentiates between septic and aseptic wound healing after orthopedic implant placement: a longitudinal study of an implant osteomyelitis in the rabbit tibia

Odekerken, J. C. E., Brans, B. T., Welting, T. J. M. & Walenkamp, G. H. I. M., Jun 2014, In : Acta Orthopaedica. 85, 3, p. 305-313 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Calcium Phosphate Based Three-Dimensional Cold Plotted Bone Scaffolds for Critical Size Bone Defects

Bergmann, C. J. D., Odekerken, J. C. E., Welting, T. J. M., Jungwirth, F., Devine, D., Bouré, L., Zeiter, S., van Rhijn, L. W., Telle, R., Fischer, H. & Emans, P. J., 1 Jan 2014, In : BioMed Research International. 2014, 10 p., 852610.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Characterization of an Ovine Bilateral Critical Sized Bone Defect Iliac Wing Model to Examine Treatment Modalities Based on Bone Tissue Engineering

Lansdowne, J. L., Devine, D., Eberli, U., Emans, P., Welting, T. J. M., Odekerken, J. C. E., Schiuma, D., Thalhauser, M., Bouré, L. & Zeiter, S., 1 Jan 2014, In : BioMed Research International. 2014, 250958.

Research output: Contribution to journalArticleAcademicpeer-review

Current Knowledge on Exostoses Formation in Hereditary Multiple Exostoses: Where do Exostoses Originate and in What Way is their Growth Regulated

Staal, H. M., Witlox, A. M. A., Mooij, D. T., Emans, P. J., Ham, J. S. J., van Rhijn, L. W. & Welting, T. J. M., 1 Jan 2014, In : Hereditary Genetics. 3, 3, 134.

Research output: Contribution to journalArticleAcademicpeer-review

Drugs and Polymers for Delivery Systems in OA Joints: Clinical Needs and Opportunities

Janssen, M., Mihov, G., Welting, T., Thies, J. & Emans, P., Mar 2014, In : Polymers. 6, 3, p. 799-819 21 p.

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Endochondral ossification in a case of progressive osseous heteroplasia in a young female child

Schrander, D. E., Welting, T. J., Caron, M. M. J., Schrander, J. J. P., van Rhijn, L. W., Körver-Keularts, I. & Schrander-Stumpel, C. T. R. M., Sep 2014, In : Journal of Pediatric Orthopaedics-Part B. 23, 5, p. 477-484 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Novel immortal human cell lines reveal subpopulations in the nucleus pulposus

van den Akker, G. G. H., Surtel, D. A. M., Cremers, A., Rodrigues-Pinto, R., Richardson, S. M., Hoyland, J. A., van Rhijn, L. W., Welting, T. J. M. & Voncken, J. W., 1 Jan 2014, In : Arthritis Research & Therapy. 16, 3, R135.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)
3 Citations (Scopus)

Targeting Inflammatory Processes for Optimization of Cartilage Homeostasis and Repair Techniques

Caron, M. M. J., Welting, T. J. M., van Rhijn, L. W. & Emans, P. J., 1 Jan 2014, Developing Insights in Cartilage Repair. Emans, P. J. & Peterson, L. (eds.). London: Springer, p. 43-63

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

The Longitudinal Assessment of Osteomyelitis Development by Molecular Imaging in a Rabbit Model

Odekerken, J. C. E., Walenkamp, G. H. I. M., Brans, B. T., Welting, T. J. M. & Arts, J. J. C., 1 Jan 2014, In : BioMed Research International. 2014, 10 p., 424652.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
2013

A rabbit osteomyelitis model for the longitudinal assessment of early post-operative implant infections

Odekerken, J. C. E., Arts, J. J. C., Surtel, D. A. M., Walenkamp, G. H. I. M. & Welting, T. J. M., 4 Nov 2013, In : Journal of Orthopaedic Surgery and Research. 8, 38.

Research output: Contribution to journalArticleAcademicpeer-review

Osmolarity determines the in vitro chondrogenic differentiation capacity of progenitor cells via nuclear factor of activated T-cells 5

Caron, M. M. J., van der Windt, A. E., Emans, P. J., van Rhijn, L. W., Jahr, H. & Welting, T. J. M., Mar 2013, In : Bone. 53, 1, p. 94-102

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

The Immediate Early Gene Product EGR1 and Polycomb Group Proteins Interact in Epigenetic Programming during Chondrogenesis

Saapen, F., van den Akker, G. G. H., Caron, M. M. J., Prickaerts, P., Rofel, C., Dahlmans, V. E. H., Surtel, D. A. M., Paulis, Y., Schweizer, F., Welting, T. J. M., Eijssen, L. M. & Voncken, J. W., 6 Mar 2013, In : PLOS ONE. 8, 3, 16 p., 58083.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
9 Citations (Scopus)

Tissue-engineered constructs: the effect of scaffold architecture in osteochondral repair

Emans, P. J., Jansen, E. J. P., van Iersel, D., Welting, T. J. M., Woodfield, T. B. F., Bulstra, S. K., Riesle, J., van Rhijn, L. W. & Kuijer, R., Sep 2013, In : Journal of Tissue Engineering and Regenerative Medicine. 7, 9, p. 751-756

Research output: Contribution to journalArticleAcademicpeer-review

2012

Activation of NF-kappa B/p65 Facilitates Early Chondrogenic Differentiation during Endochondral Ossification

Caron, M. M. J., Emans, P. J., Surtel, D. A. M., Cremers, A., Voncken, J. W., Welting, T. J. M. & van Rhijn, L. W., 12 Mar 2012, In : PLOS ONE. 7, 3, e33467.

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)
87 Citations (Scopus)
2010

Autologous engineering of cartilage

Emans, P. J., van Rhijn, L. W., Welting, T. J. M., Cremers, A., Wijnands, N., Spaapen, F., Voncken, J. W. & Shastri, V. P., 23 Feb 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 8, p. 3418-3423

Research output: Contribution to journalArticleAcademicpeer-review

Physiological tonicity improves human chondrogenic marker expression through nuclear factor of activated T-cells 5 in vitro

van der Windt, A. E., Haak, E., Das, R. H. J., Kops, N., Welting, T. J. M., Caron, M. M. J., van Til, N. P., Verhaar, J. A. N., Weinans, H. & Jahr, H., 2010, In : Arthritis Research & Therapy. 12, 3, p. R100

Research output: Contribution to journalArticleAcademicpeer-review