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Research Output 2012 2018

2017

Blood-derived macrophages prone to accumulate lysosomal lipids trigger oxLDL-dependent murine hepatic inflammation

Houben, T., Oligschlaeger, Y., Bitorina, A. V., Hendrikx, T., Walenbergh, S. M. A., Lenders, M-H., Gijbels, M. J. J., Verheyen, F., Luetjohann, D., Hofker, M. H., Binder, C. J. & Shiri-Sverdlov, R., 2 Oct 2017, In : Scientific Reports. 7, 9 p., 12550.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cathepsin D regulates lipid metabolism in murine steatohepatitis

Houben, T., Oligschlaeger, Y., Hendrikx, T., Bitorina, A. V., Walenbergh, S. M. A., van Gorp, P. J., Gijbels, M. J. J., Friedrichs, S., Plat, J., Schaap, F. G., Luetjohann, D., Hofker, M. H. & Shiri-Sverdlov, R., 14 Jun 2017, In : Scientific Reports. 7, 10 p., 3494.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Malondialdehyde Epitopes Are Sterile Mediators of Hepatic Inflammation in Hypercholesterolemic Mice

Busch, C. J-L., Hendrikx, T., Weismann, D., Jaeckel, S., Walenbergh, S. M. A., Rendeiro, A. F., Weisser, J., Puhm, F., Hladik, A., Goederle, L., Papac-Milicevic, N., Haas, G., Millischer, V., Subramaniam, S., Knapp, S., Bennett, K. L., Bock, C., Reinhardt, C., Shiri-Sverdlov, R. & Binder, C. J., Apr 2017, In : Hepatology. 65, 4, p. 1181-1195 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Cholesterol and liver inflammation: from mice to human

Walenbergh, S., Hendrikx, T. & Shiri - Sverdlov, R., 2016, Protein Purification: Principles and Trends. iConcept Press, 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

1 Citation (Scopus)

Low levels of IgM antibodies recognizing oxidation-specific epitopes are associated with human non-alcoholic fatty liver disease

Hendrikx, T., Watzenboeck, M. L., Walenbergh, S. M. A., Amir, S., Gruber, S., Kozma, M. O., Grabsch, H. I., Koek, G. H., Pierik, M. J., Staufer, K., Trauner, M., Kalhan, S. C., Jonkers, D., Hofker, M. H., Binder, C. J. & Shiri-Sverdlov, R., 22 Jul 2016, In : BMC Medicine. 14, 13 p., 107.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in LdIr(-/-) Mice

Jeurissen, M. L. J., Walenbergh, S. M. A., Houben, T., Hendrikx, T., Li, J., Oligschläger, Y., van Gorp, P. J., Gijbels, M. J. J., Bitorina, A., Nessel, I., Radtke, F., Vooijs, M., Theys, J. & Shiri-Sverdlov, R., 29 Nov 2016, In : PLOS ONE. 11, 11, e0167199.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention

Walenbergh, S. M. A., Houben, T., Rensen, S. S., Bieghs, V., Hendrikx, T., van Gorp, P. J., Oligschläger, Y., Jeurissen, M. L. J., Gijbels, M. J. J., Buurman, W. A., Vreugdenhil, A. C. E., Greve, J. W. M., Plat, J., Hofker, M. H., Kalhan, S., Pihlajamaki, J., Lindsey, P., Koek, G. H. & Shiri-Sverdlov, R., 6 Dec 2016, In : Scientific Reports. 6, 38278.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr(-/-) mice

Jeurissen, M. L. J., Walenbergh, S. M. A., Houben, T., Gijbels, M. J. J., Li, J., Hendrikx, T., Oligschläger, Y., van Gorp, P. J., Binder, C. J., Donners, M. M. P. C. & Shiri-Sverdlov, R., Dec 2016, In : Atherosclerosis. 255, p. 59-65

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells

Gruber, S., Hendrikx, T., Tsiantoulas, D., Ozsvar-Kozma, M., Goederle, L., Mallat, Z., Witztum, J. L., Shiri-Sverdlov, R., Nitschke, L. & Binder, C. J., 15 Mar 2016, In : Cell Reports. 14, 10, p. 2348-2361

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015
5 Citations (Scopus)

Bone marrow-specific caspase-1/11 deficiency inhibits atherosclerosis development in Ldlr(-/-) mice

Hendrikx, T., Jeurissen, M. L. J., van Gorp, P. J., Gijbels, M. J., Walenbergh, S. M. A., Houben, T., van Gorp, R., Pottgens, C. C., Stienstra, R., Netea, M. G., Hofker, M., Donners, M. M. & Shiri-Sverdlov, R., 1 Jan 2015, In : FEBS Journal. 282, 12, p. 2327-2338

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr(-/-) mice

Hendrikx, T., Jeurissen, M. L. J., Bieghs, V., Walenbergh, S. M. A., van Gorp, P. J., Verheyen, F., Houben, T., Guichot, Y. D., Gijbels, M. J., Leitersdorf, E., Hofker, M. H., Luetjohann, D. & Shiri-Sverdlov, R., Feb 2015, In : Journal of Hepatology. 62, 2, p. 430-436 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

235 Downloads (Pure)

Intracellular traffic jam : cholesterol accumulation as cause for chronic inflammatory diseases

Hendrikx, T., 1 Jan 2015, Maastricht: Maastricht University. 182 p.

Research output: ThesisDoctoral ThesisInternal

Open Access
File
9 Citations (Scopus)

Plasma cathepsin d levels: a novel tool to predict pediatric hepatic inflammation

Walenbergh, S. M., Houben, T., Hendrikx, T., Jeurissen, M. L. J., van Gorp, P. J., Vreugdenhil, A. C., Adriaanse, M., Buurman, W., Hofker, M., Mosca, A., Lindsey, P. J., Alisi, A., Liccardo, D., Panera, N., Koek, G. H., Nobili, V. & Shiri-Sverdlov, R., 1 Jan 2015, In : American Journal of Gastroenterology. 110, 3, p. 462-470

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells

Wang, Y., van der Tuin, S., Tjeerdema, N., van Dam, A. D., Rensen, S. S., Hendrikx, T., Berbée, J. F. P., Atanasovska, B., Fu, J., Hoekstra, M., Bekkering, S., Riksen, N. P., Buurman, W. A., Greve, J. W., Hofker, M. H., Shiri-Sverdlov, R., Meijer, O. C., Smit, J. W. A., Havekes, L. M., van Dijk, K. W. & 1 others, Rensen, P. C. N., Dec 2015, In : Hepatology. 62, 6, p. 1710-1722 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Plasma IL-1 receptor antagonist levels correlate with the development of non-alcoholic steatohepatitis

Hendrikx, T., Walenbergh, S. M., Jeurissen, M., Houben, T., van Gorp, P. J., Lindsey, P. J., Koek, G. H., Kalhan, S., Pihlajamaki, J., Hofker, M. H. & Shiri-Sverdlov, R., 1 Jan 2015, In : Biomarkers in Medicine. 9, 12, p. 1301-1309 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Weekly Treatment of 2-Hydroxypropyl-beta-cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice

Walenbergh, S. M., Houben, T., Hendrikx, T., Jeurissen, M. L., van Gorp, P. J. J., Vaes, N., Olde Damink, S. W. M., Verheyen, F., Koek, G. H., Lutjohann, D., Grebe, A., Latz, E. & Shiri-Sverdlov, R., Sep 2015, In : International journal of molecular sciences. 16, 9, p. 21056-21069 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014
14 Citations (Scopus)

Lysosomal cholesterol accumulation: driver on the road to inflammation during atherosclerosis and non-alcoholic steatohepatitis

Hendrikx, T., Walenbergh, S., Hofker, M. H. & Shiri-Sverdlov, R., May 2014, In : Obesity Reviews. 15, 5, p. 424-433 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Protective role of plant sterol and stanol esters in liver inflammation: insights from mice and humans

Plat, J., Hendrikx, T., Bieghs, V., Jeurissen, M. L. J., Walenbergh, S. M., van Gorp, P. J., de Smet, E., Konings, M., Vreugdenhil, A. C., Guichot, Y. D., Rensen, S. S., Buurman, W., Greve, J., Lutjohann, D., Mensink, R. P. & Shiri-Sverdlov, R., 1 Jan 2014, In : PLOS ONE. 9, 10, e110758.

Research output: Contribution to journalArticleAcademicpeer-review

2013
8 Citations (Scopus)

Macrophage Specific Caspase-1/11 Deficiency Protects against Cholesterol Crystallization and Hepatic Inflammation in Hyperlipidemic Mice

Hendrikx, T., Bieghs, V., Walenbergh, S. M., van Gorp, P. J., Verheyen, F., Jeurissen, M. L., Steinbusch, M. M., Vaes, N., Binder, C. J., Koek, G. H., Stienstra, R., Netea, M. G., Hofker, M. H. & Shiri-Sverdlov, R., 1 Jan 2013, In : PLOS ONE. 8, 12, e78792.

Research output: Contribution to journalArticleAcademicpeer-review

29 Citations (Scopus)

The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice.

Bieghs, V., Hendrikx, T., van Gorp, P. J. J., Verheyen, F., Guichot, Y. D., Walenbergh, S. M., Gijbels, M. J. J., Rensen, S. S. M., Bast, A., Plat, J., Kalhan, S. C., Leitersdorf, E., Hofker, M. H., Lutjohann, D. & Shiri-Sverdlov, R., 1 Jan 2013, In : Gastroenterology. 144, 1, p. 167-178.e1

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation.

Bieghs, V., Walenbergh, S. M., Hendrikx, T., van Gorp, P. J. J., Verheyen, F., Olde Damink, S., Masclee, A. A. M., Koek, G. H., Hofker, M., Binder, C. J. & Shiri-Sverdlov, R., Aug 2013, In : Liver International. 33, 7, p. 1056-1061 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

2012
46 Citations (Scopus)

Internalization of modified lipids by cd36 and sr-a leads to hepatic inflammation and lysosomal cholesterol storage in kupffer cells

Bieghs, V., Verheyen, F., van Gorp, P. J., Hendrikx, T., Wouters, K., Lutjohann, D., Gijbels, M. J., Febbraio, M., Binder, C. J., Hofker, M. H. & Sverdlov, R., 28 Mar 2012, In : PLOS ONE. 7, 3, 7 p., e34378.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
49 Citations (Scopus)

LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease

Bieghs, V., van Gorp, P. J., Wouters, K., Hendrikx, T., Gijbels, M. J., van Bilsen, M., de Bakker, J., Binder, C. J., Lutjohann, D., Staels, B., Hofker, M. H. & Sverdlov, R., 25 Jan 2012, In : PLOS ONE. 7, 1, e30668.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access