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Research Output 1992 2020

2020
Open Access
2019

A Co-expression Analysis of the Placental Transcriptome in Association With Maternal Pre-pregnancy BMI and Newborn Birth Weight

Cox, B., Tsamou, M., Vrijens, K., Neven, K. Y., Winckelmans, E., de Kok, T. M., Plusquin, M. & Nawrot, T. S., 29 Apr 2019, In : Frontiers in Genetics. 10, p. 1-13 13 p., 354.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data

O'Donovan, S. D., Lenz, M., Vink, R. G., Roumans, N. J. T., de Kok, T. M. C. M., Mariman, E. C. M., Peeters, R. L. M., van Riel, N. A. W., van Baak, M. A. & Arts, I. C. W., Oct 2019, In : PLoS Computational Biology. 15, 10, 23 p., e1007400.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cell-free, circulating microRNAs reflect air pollution-induced environmental health risks

Krauskopf, J., van Veldhoven, K., Chadeau-Hyam, M., Vermeulen, R., Carrasco-Turigas, G., Nieuwenhuijsen, M., Vineis, P., de Kok, T. M. & Kleinjans, J. C. S., 15 Oct 2019, In : Toxicology Letters. 314, p. S68-S68 1 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Consumption of Nitrate-Rich Beetroot Juice with or without Vitamin C Supplementation Increases the Excretion of Urinary Nitrate, Nitrite, and N-nitroso Compounds in Humans

Berends, J. E., van den Berg, L. M. M., Guggeis, M. A., Henckens, N. F. T., Hossein, I. J., de Joode, M. E. J. R., Zamani, H., van Pelt, K. A. A. J., Beelen, N. A., Kuhnle, G. G., de Kok, T. M. C. M. & Van Breda, S. G. J., 1 May 2019, In : International Journal of Molecular Sciences. 20, 9, 15 p., 2277.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches

Rodrigues, D., Souza, T., Jennen, D. G. J., Lemmens, L., Kleinjans, J. C. S. & de Kok, T. M., Jul 2019, In : Cancer Treatment Reviews. 77, p. 57-66 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity

Jiang, J., Messner, S., Kelm, J. M., van Herwijnen, M., Jennen, D. G. J., Kleinjans, J. C. & de Kok, T. M., 15 Sep 2019, In : Toxicology Letters. 312, p. 34-44 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification of Sex-Specific Transcriptome Responses to Polychlorinated Biphenyls (PCBs)

Espin-Perez, A., Hebels, D. G. A. J., Kiviranta, H., Rantakokko, P., Georgiadis, P., Botsivali, M., Bergdahl, I. A., Palli, D., Spath, F., Johansson, A., Chadeau-Hyam, M., Kyrtopoulos, S. A., Kleinjans, J. C. S. & de Kok, T. M. C. M., 24 Jan 2019, In : Scientific Reports. 9, p. 1-12 12 p., 746.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Impact of high drinking water nitrate levels on the endogenous formation of apparent N-nitroso compounds in combination with meat intake in healthy volunteers

van Breda, S. G., Mathijs, K., Sagi-Kiss, V., Kuhnle, G. G., Van der Veer, B., Jones, R. R., Sinha, R., Ward, M. H. & de Kok, T. M., 17 Oct 2019, In : Environmental Health. 18, 1, 12 p., 87.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Integration of extracellular metabolomics and intracellular transcriptomics to unravel the mechanisms of 5-FU-induced gastrointestinal toxicity

Souza, T., Rodrigues, D. F., Schrooders, Y., Coyle, L., Vappiani, J., Sevin, D., Jennen, D., Kleinjans, J. C. S. & de Kok, T. M., 15 Oct 2019, In : Toxicology Letters. 314, p. S148-S149 2 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Optimization of a 5-Fluorouracil-induced intestinal injury model in mice to construct a multi-scale predictive model of drug-induced intestinal toxicity

Jardi, F., Van Heerden, M., Vereyken, L., Erkens, T., Rodrigues, D. F., Kleinjans, J. C. S., de Kok, T. M., Ferreria, S., Gardner, I., Fisher, C., Pritchard, M., Lynch, A., Sevin, D., Beattie, K., Pin, C., Lammens, L. & de Jonghe, S., 15 Oct 2019, In : Toxicology Letters. 314, p. S73-S74 2 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Short-term exposure to traffic-related air pollution reveals a compound-specific circulating miRNA profile indicating multiple disease risks

Krauskopf, J., van Veldhoven, K., Chadeau-Hyam, M., Vermeulen, R., Carrasco-Turigas, G., Nieuwenhuijsen, M., Vineis, P., de Kok, T. M. & Kleinjans, J. C., Jul 2019, In : Environment International. 128, p. 193-200 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The application of omics-based human liver platforms for investigating the mechanism of drug-induced hepatotoxicity in vitro

Jiang, J., Pieterman, C. D., Ertaylan, G., Peeters, R. L. M. & de Kok, T. M. C. M., 5 Oct 2019, In : Archives of Toxicology. 93, 11, p. 3067-3098 32 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

The Cord Blood Insulin and Mitochondrial DNA Content Related Methylome

Reimann, B., Janssen, B. G., Alfano, R., Ghantous, A., Espin-Perez, A., de Koko, T. M., Saenen, N. D., Cox, B., Robinson, O., Chadeau-Hyam, M., Penders, J., Herceg, Z., Vineis, P., Nawrot, T. S. & Plusquin, M., 12 Apr 2019, In : Frontiers in Genetics. 10, p. 1-15 15 p., 325.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Transcriptome changes in undifferentiated Caco-2 cells exposed to food-grade titanium dioxide (E171): contribution of the nano- and micro- sized particles

Proquin, H., Jonkhout, M. C. M., Jetten, M. J., van Loveren, H., de Kok, T. M. & Briede, J. J., 4 Dec 2019, In : Scientific Reports. 9, 14 p., 18287.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Transcriptomic approach to improve the understanding of 5-fluorouracil (5-FU) induced intestinal toxicity in vitro and in vivo

Rodrigues, D. F., de Souza, T., Coyle, L., Schrooders, Y., Jardi, F., de Jonghe, S., van Heerden, M., Lammens, L., Jennen, D., Kleinjans, J. C. & de Kok, T. M., 15 Oct 2019, In : Toxicology Letters. 314, p. S88-S89 2 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

2018

Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma: findings from two prospective cohorts

Berger, E., Delpierre, C., Hosnijeh, F. S., Kelly-Irving, M., Portengen, L., Bergdahl, I. A., Johansson, A-S., Krogh, V., Palli, D., Panico, S., Sacerdote, C., Tumino, R., Kyrtopoulos, S. A., Vineis, P., Chadeau-Hyam, M., Vermeulen, R., Castagne, R. & de Kok, T., 17 Jul 2018, In : Scientific Reports. 8, p. 1-9 9 p., 10805.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Blood transcriptional and microRNA responses to short-term exposure to disinfection by-products in a swimming pool

Espin-Perez, A., Font-Ribera, L., van Veldhoven, K., Krauskopf, J., Portengen, L., Chadeau-Hyam, M., Vermeulen, R., Grimalt, J. O., Villanueva, C. M., Vineis, P., Kogevinas, M., Kleinjans, J. C. & de Kok, T. M., 1 Jan 2018, In : Environment International. 110, p. 42-50 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Comparison of statistical methods and the use of quality control samples for batch effect correction in human transcriptome data

Espin-Perez, A., Portier, C., Chadeau-Hyam, M., van Veldhoven, K., Kleinjans, J. C. S. & de Kok, T. M. C. M., 30 Aug 2018, In : PLOS ONE. 13, 8, 19 p., 0202947.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Data on novel DNA methylation changes induced by valproic acid in human hepatocytes

Wolters, JJ., van Breda, SJ., Claessen, S., de Kok, TCM. & Kleinjans, JS., Feb 2018, In : Data in brief. 16, p. 161-171 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Drinking Water Nitrate and Human Health: An Updated Review

Ward, M. H., Jones, R. R., Brender, J. D., de Kok, T. M., Weyer, P. J., Nolan, B. T., Villanueva, C. M. & van Breda, S. G., 23 Jul 2018, In : International Journal of Environmental Research and Public Health. 15, 7, 31 p., 1557.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Epigenome-wide association study of adiposity and future risk of obesity-related diseases

Campanella, G., Gunter, M. J., Polidoro, S., Krogh, V., Palli, D., Panico, S., Sacerdote, C., Tumino, R., Fiorito, G., Guarrera, S., Iacoviello, L., Bergdahl, I. A., Melin, B., Lenner, P., de Kok, T. M. C. M., Georgiadis, P., Kleinjans, J. C. S., Kyrtopoulos, S. A., Bueno-de-Mesquita, H. B., Lillycrop, K. A. & 15 others, May, A. M., Onland-Moret, N. C., Murray, R., Riboli, E., Verschuren, M., Lund, E., Mode, N., Sandanger, T. M., Fiano, V., Trevisan, M., Matullo, G., Froguel, P., Elliott, P., Vineis, P. & Chadeau-Hyam, M., Dec 2018, In : International Journal of Obesity. 42, 12, p. 2022-2035 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Exploring the cellular network of metabolic flexibility in the adipose tissue

Tareen, S. H. K., Kutmon, M., Adriaens, M., Mariman, E., de Kok, T., Arts, I. & Evelo, C., 5 Jul 2018, In : Genes and nutrition. 13, 8 p., 17.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Gene expression profiling in colon of mice exposed to food additive titanium dioxide (E171)

Proquin, H., Jetten, M. J., Jonkhout, M. C. M., Garduno-Balderas, L. G., Briede, J. J., de Kok, T. M., Chirino, Y. I. & van Loveren, H., 1 Jan 2018, In : Food and Chemical Toxicology. 111, p. 153-165 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Health effects of red meat products containing phytochemicals and reduced levels of nitrite: the PHYTOME project

10 Oct 2018, In : Toxicology Letters. 295, p. S141-S142 2 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Ophthalmic acid as a read-out for hepatic glutathione metabolism in humans

Kim Mc van, M., Dello, S. A., de Jong, M. C., van Eijk, H. M., de Kok, T. M., Briedé, J. J., Schaap, F. G., Damink, S. W. O. & Dejong, C. H., 30 Jul 2018, In : Journal of clinical and translational research. 3, Suppl 2, p. 366-374 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens

Limonciel, A., van Breda, S. G., Jiang, X., Tredwell, G. D., Wilmes, A., Aschauer, L., Siskos, A. P., Sachinidis, A., Keun, H. C., Kopp-Schneider, A., de Kok, T. M., Kleinjans, J. C. S. & Jennings, P., 3 Dec 2018, In : Frontiers in Genetics. 9, 15 p., 558.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pre-diagnostic blood immune markers, incidence and progression of B-cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses

Vermeulen, R., Hosnijeh, F. S., Bodinier, B., Portengen, L., Liquet, B., Garrido-Manriquez, J., Lokhorst, H., Bergdahl, I. A., Kyrtopoulos, S. A., Johansson, A-S., Georgiadis, P., Melin, B., Palli, D., Krogh, V., Panico, S., Sacerdote, C., Tumino, R., Vineis, P., Castagne, R., Chadeau-Hyam, M. & 30 others, Botsivali, M., Chatziioannou, A., Valavanis, I., Kleinjans, J. C. S., de Kok, T. M. C. M., Keun, H. C., Athersuch, T. J., Kelly, R., Lenner, P., Hallmans, G., Stephanou, E. G., Myridakis, A., Kogevinas, M., Fazzo, L., De Santis, M., Comba, P., Bendinelli, B., Kiviranta, H., Rantakokko, P., Airaksinen, R., Ruokojarvi, P., Gilthorpe, M., Fleming, S., Fleming, T., Tu, Y-K., Lundh, T., Chien, K-L., Chen, W. J., Lee, W-C. & Hsiao, C. K., 15 Sep 2018, In : International Journal of Cancer. 143, 6, p. 1335-1347 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Profiling cellular processes in adipose tissue during weight loss using time series gene expression

Tareen, S. H. K., Adriaens, M. E., Arts, I. C. W., de Kok, T. M., Vink, R. G., Roumans, N. J. T., van Baak, M. A., Mariman, E. C. M., Evelo, C. T. & Kutmon, M., Nov 2018, In : Genes. 9, 11, 16 p., 525.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Short-term exposure to ambient motor vehicle emissions perturb the human circulating miRNA genome

Krauskopf, J., Caiment, F., van Veldhoven, K., Chadeau-Hyam, M., Sinharay, R., Chung, K. F., Cullinan, P., Collins, P., Barratt, B., Kelly, F. J., Vermeulen, R., de Kok, T. M. & Kleinjans, J. C. S., 10 Oct 2018, In : Toxicology Letters. 295, p. S85-S85 1 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Short-term transcriptome and microRNAs responses to exposure to different air pollutants in two population studies

Espin-Perez, A., Krauskopf, J., Chadeau-Hyam, M., van Veldhoven, K., Chung, F., Cullinan, P., Piepers, J., van Herwijnen, M., Kubesch, N., Carrasco-Turigas, G., Nieuwenhuijsen, M., Vineis, P., Kleinjans, J. C. S. & de Kok, T. M. C. M., Nov 2018, In : Environmental Pollution. 242, p. 182-190 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity

Scupakova, K., Soons, Z., Ertaylan, G., Pierzchalski, K. A., Eijkel, G. B., Ellis, S. R., Greve, J. W., Driessen, A., Verheij, J., De Kok, T. M., Damink, S. W. M. O., Rensen, S. S. & Heeren, R. M. A., 17 Apr 2018, In : Analytical Chemistry. 90, 8, p. 5130-5138 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The human circulating miRNome reflects multiple organ disease risks in association with short-term exposure to traffic-related air pollution

Krauskopf, J., Caiment, F., van Veldhoven, K., Chadeau-Hyam, M., Sinharay, R., Chung, K. F., Cullinan, P., Collins, P., Barratt, B., Kelly, F. J., Vermeulen, R., Vineis, P., de Kok, T. M. & Kleinjans, J. C., 1 Apr 2018, In : Environment International. 113, p. 26-34 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Time course gene expression data in colon of mice after exposure to food-grade E171

Proquin, H., Jetten, M. J., Jonkhout, M. C. M., Garduño-Balderas, L. G., Briedé, J. J., de Kok, T. M., Chirino, Y. I. & van Loveren, H., Feb 2018, In : Data in brief. 16, p. 531-600 70 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions

Proquin, H., Rodríguez-Ibarra, C., Moonen, C., Urrutia Ortega, I. M., Briedé, J. J., de Kok, T. M., van Loveren, H. & Irasema Chirino, Y., 17 Sep 2018, In : Mutagenesis. 33, 3, p. 267-268 2 p.

Research output: Contribution to journalErratum / corrigendumAcademic

Transcriptome responses in Caco-2 cells to micro- and nanoparticles in food-grade titanium dioxide (El 71) and potential impact on colon cancer development

Briede, J., Proquin, H., de Kok, T. M. & van Loveren, H., 10 Oct 2018, In : Toxicology Letters. 295, p. S142-S143 2 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Transcriptomics analysis reveals new insights in E171-induced molecular alterations in a mouse model of colon cancer

Proquin, H., Jetten, M. J., Jonkhout, M. C. M., Garduno-Balderas, L., Briede, J. J., de Kok, T. M., van Loveren, H. & Chirino, Y. I., 27 Jun 2018, In : Scientific Reports. 8, 16 p., 9738.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A Comparative Study on the WCRF International/University of Bristol Methodology for Systematic Reviews of Mechanisms Underpinning Exposure-Cancer Associations

Ertaylan, G., Le Cornet, C., van Roekel, E. H., Jung, A. Y., Bours, M. J. L., Damms-Machado, A., van den Brandt, P. A., Schock, H., de Kok, T. M., Theys, J., Arts, I. C. W., Kaaks, R., Weijenberg, M. P. & Fortner, R. T., Nov 2017, In : Cancer Epidemiology Biomarkers & Prevention. 26, 11, p. 1583-1594 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

Chatziioannou, A., Georgiadis, P., Hebels, D. G., Liampa, I., Valavanis, I., Bergdahl, I. A., Johansson, A., Palli, D., Chadeau-Hyam, M., Siskos, A. P., Keun, H., Botsivali, M., de Kok, T. M. C. M., Perez, A. E., Kleinjans, J. C. S., Vineis, P. & Kyrtopoulos, S. A., 22 Feb 2017, In : Scientific Reports. 7, 13 p., 42870.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis

Georgiadis, P., Liampa, I., Hebels, D. G., Krauskopf, J., Chatziioannou, A., Valavanis, I., de Kok, T. M. C. M., Kleinjans, J. C. S., Bergdahl, I. A., Melin, B., Spaeth, F., Palli, D., Vermeulen, R. C. H., Vlaanderen, J., Chadeau-Hyam, M., Vineis, P. & Kyrtopoulos, S. A., 13 Sep 2017, In : BMC Genomics. 18, 15 p., 728.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Exploring the nature of prediagnostic blood transcriptome markers of chronic lymphocytic leukemia by assessing their overlap with the transcriptome at the clinical stage

Vlaanderen, J., Leenders, M., Chadeau-Hyam, M., Portengen, L., Kyrtopoulos, S. A., Bergdahl, I. A., Johansson, A-S., Hebels, D. D. G. A. J., de Kok, T. M. C. M., Vineis, P. & Vermeulen, R. C. H., 20 Mar 2017, In : BMC Genomics. 18, 8 p., 239.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery

Krauskopf, J., de Kok, T. M., Hebels, D. G., Bergdahl, I. A., Johansson, A., Spaeth, F., Kiviranta, H., Rantakokko, P., Kyrtopoulos, S. A. & Kleinjans, J. C., 23 Aug 2017, In : Scientific Reports. 7, 9 p., 9262.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth cohort

Winckelmans, E., Vrijens, K., Tsamou, M., Janssen, B. G., Saenen, N. D., Roels, H. A., Kleinjans, J., Lefebvre, W., Vanpoucke, C., de Kok, T. M. & Nawrot, T. S., 5 Jun 2017, In : Environmental Health. 16, 17 p., 52.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access