20052019

Research output per year

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Research Output

2019

Biological variation of cardiac markers in patients with aortic valve stenosis

Peeters, F. E. C. M., Kietselaer, B. L. J. H., Hilderink, J., van der Linden, N., Niens, M., Crijns, H. J. G. M. & Meex, S. J. R., Jan 2019, In : Open Heart. 6, 1, 7 p., 001040.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Incidence of cardiovascular disease in familial combined hyperlipidemia: A 15-year follow-up study

Luijten, J., van Greevenbroek, M. M. J., Schaper, N. C., Meex, S. J. R., van der Steen, C., Meijer, L. J., de Boer, D., de Graaf, J., Stehouwer, C. D. A. & Brouwers, M. C. G. J., Jan 2019, In : Atherosclerosis. 280, p. 1-6 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Multi-Site Coronary Vein Sampling Study on Cardiac Troponin T Degradation in Non-ST-Segment-Elevation Myocardial Infarction: Toward a More Specific Cardiac Troponin T Assay

Damen, S. A. J., Vroemen, W. H. M., Brouwer, M. A., Mezger, S. T. P., Suryapranata, H., van Royen, N., Bekers, O., Meex, S. J. R., Wodzig, W. K. W. H., Verheugt, F. W. A., de Boer, D., Cramer, G. E. & Mingels, A. M. A., 16 Jul 2019, In : Journal of the American Heart Association. 8, 14, 26 p., 012602.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Sex-Specific Thresholds of High-Sensitivity Troponin in Patients With Suspected Acute Coronary Syndrome

Lee, K. K., Ferry, A. V., Anand, A., Strachan, F. E., Chapman, A. R., Kimenai, D. M., Meex, S. J. R., Berry, C., Findlay, I., Reid, A., Cruickshank, A., Gray, A., Collinson, P. O., Apple, F. S., McAllister, D. A., Maguire, D., Fox, K. A. A., Newby, D. E., Tuck, C., Keerie, C. & 4 others, Weir, C. J., Shah, A. S. V., Mills, N. L. & High-STEACS Investigators, 22 Oct 2019, In : Journal of the American College of Cardiology. 74, 16, p. 2032-2043 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Biological Variation of Creatinine, Cystatin C, and eGFR over 24 Hours

Hilderink, J. M., van der Linden, N., Kimenai, D. M., Litjens, E. J. R., Klinkenberg, L. J. J., Aref, B. M., Aziz, F., Kooman, J. P., Rennenberg, R. J. M. W., Bekers, O., Koopmans, R. P. & Meex, S. J. R., May 2018, In : Clinical Chemistry. 64, 5, p. 851-860 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Calcific aortic valve stenosis: hard disease in the heart

Peeters, F. E. C. M., Meex, S. J. R., Dweck, M. R., Aikawa, E., Crijns, H. J. G. M., Schurgers, L. J. & Kietselaer, B. L. J. H., 21 Jul 2018, In : European Heart Journal. 39, 28, p. 2618–2624 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction

Wildi, K., Singeisen, H., Twerenbold, R., Badertscher, P., Wussler, D., Klinkenberg, L. J. J., Meex, S. J. R., Nestelberger, T., Boeddinghaus, J., Miro, O., Martin-Sanchez, F. J., Morawiec, B., Muzyk, P., Parenica, J., Keller, D. I., Geigy, N., Potlukova, E., Sabti, Z., Kozhuharov, N., Puelacher, C. & 9 others, de Lavallaz, J. D. F., Gimenez, M. R., Shrestha, S., Marzano, G., Rentsch, K., Osswald, S., Reichlin, T., Mueller, C. & APACE Investigators, 1 Nov 2018, In : International Journal of Cardiology. 270, p. 14-20 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Combining High-Sensitivity Cardiac Troponin I and Cardiac Troponin T in the Early Diagnosis of Acute Myocardial Infarction

van der Linden, N., Wildi, K., Twerenbold, R., Pickering, J. W., Than, M., Cullen, L., Greenslade, J., Parsonage, W., Nestelberger, T., Boeddinghaus, J., Badertscher, P., Gimenez, M., Klinkenberg, L. J. J., Bekers, O., Schoni, A., Keller, D. I., Sabti, Z., Puelacher, C., Cupa, J., Schumacher, L. & 22 others, Kozhuharov, N., Grimm, K., Shrestha, S., Flores, D., Freese, M., Stelzig, C., Strebel, I., Miro, O., Rentsch, K., Morawiec, B., Kawecki, D., Kloos, W., Lohrmann, J., Richards, A. M., Troughton, R., Pemberton, C., Osswald, S., van Dieijen-Visser, M. P., Mingels, A. M., Reichlin, T., Meex, S. J. R. & Mueller, C., 4 Sep 2018, In : Circulation. 138, 10, p. 989-999 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Elevated Cardiac Troponin T in Skeletal Myopathies: Skeletal TnT Cross-Reactivity and/or Cardiac TnT Expression?

Vroemen, W. H. M., de Boer, D., Streng, A. S., Mingels, A. M. A. & Meex, S. J. R., 17 Jul 2018, In : Journal of the American College of Cardiology. 72, 3, p. 347-349 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Mass Spectrometric Identification of Cardiac Troponin T in Urine of Patients Suffering from Acute Myocardial Infarction

Streng, A., van der Linden, N., Kocken, J. M. M., Bekers, O., Bouwman, F., Mariman, E., Meex, S. & Wodzig, W., May 2018, In : The Journal of Applied Laboratory Medicine . 2, 6, p. 857-867 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Sex-Specific Versus Overall Clinical Decision Limits for Cardiac Troponin I and T for the Diagnosis of Acute Myocardial Infarction: A Systematic Review

Kimenai, D. M., Janssen, E. B. N. J., Eggers, K. M., Lindahl, B., den Ruijter, H. M., Bekers, O., Appelman, Y. & Meex, S. J. R., Jul 2018, In : Clinical Chemistry. 64, 7, p. 1034-1043 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

151 Downloads (Pure)
2017
Open Access
Open Access

Large Variation in Measured Cardiac Troponin T Concentrations after Standard Addition in Serum or Plasma of Different Individuals

van der Linden, N., Streng, A. S., Bekers, O., Wodzig, W. K. W. H., Meex, S. J. R. & de Boer, D., Jul 2017, In : Clinical Chemistry. 63, 7, p. 1300-1302 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Origin of Cardiac Troponin T Elevations in Chronic Kidney

van der Linden, N., Cornelis, T., Kimenai, D. M., Klinkenberg, L. J. J., Hilderink, J. M., Luck, S., Litjens, E. J. R., Peeters, F. E. C. M., Streng, A. S., Breidthardt, T., van Loon, L. J. C., Bekers, O., Kooman, J. P., Westermark, P. O., Mueller, C. & Meex, S. J. R., 12 Sep 2017, In : Circulation. 136, 11, p. 1073-1075 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Twenty-Four-Hour Biological Variation Profiles of Cardiac Troponin I in Individuals with or without Chronic Kidney Disease

van der Linden, N., Hilderink, J. M., Cornelisa, T., Kimenai, D. M., Klinkenbergb, L. J. J., van Doorn, W. P., Litjens, E. J. R., van Suijlen, J. D. E., van Loon, L. J. C., Bekers, O., Kooman, J. P. & Meex, S. J. R., Oct 2017, In : Clinical Chemistry. 63, 10, p. 1655-1656 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Within-day biological variation and hour-to-hour reference change values for hematological parameters

Hilderink, J. M., Klinkenberg, L. J. J., Aakre, K. M., de Wit, N. C. J., Henskens, Y. M. C., van der Linden, N., Bekers, O., Rennenberg, R. J. M. W., Koopmans, R. P. & Meex, S. J. R., Jul 2017, In : Clinical Chemistry and Laboratory Medicine. 55, 7, p. 1013-1024 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Cardiac Troponin T and I Release After a 30-km Run

Klinkenberg, L. J. J., Luyten, P., van der Linden, N., Urgel, K., Snijders, D. P. C., Knackstedt, C., Dennert, R., Kietselaer, B. L. J. H., Mingels, A., Cardinaels, E. P. M., Peeters, F. E. C. M., van Suijlen, J. D. E., ten Kate, J., Marsch, E., Theelen, T. L., Sluimer, J. C., Wouters, K., Bekers, O., Bekkers, B., van Loon, L. & 2 others, Visser - van Dieijen, M. & Meex, S. J. R., 15 Jul 2016, In : American Journal of Cardiology. 118, 2, p. 281-287

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Clinical and echocardiographic determinants in bicuspid aortic dilatation Results from a longitudinal observational study

Peeters, F. E. C. M., Van der Linden, N., Thomassen, A. L. L., Crijns, H. J. G. M., Meex, S. J. R. & Kietselaer, B. L. J. H., Dec 2016, In : Medicine. 95, 52, 6 p., e5699.

Research output: Contribution to journalArticleAcademicpeer-review

Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia

Marsch, E., Demandt, J. A. F., Theelen, T. L., Tullemans, B. M. E., Wouters, K., Boon, M. R., van Dijk, T. H., Gijbels, M. J., Dubois, L. J., Meex, S. J. R., Mazzone, M., Hung, G., Fisher, E. A., Biessen, E. A. L., Daemen, M. J. A. P., Rensen, P. C. N., Carmeliet, P., Groen, A. K. & Sluimer, J. C., 14 Oct 2016, In : European Heart Journal. 37, 39, p. 2993-2997

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Direct comparison of clinical decision limits for cardiac troponin T and I

Kimenai, D. M., Henry, R. M. A., van der Kallen, C. J. H., Dagnelie, P. C., Schram, M. T., Stehouwer, C. D. A., van Suijlen, J. D. E., Niens, M., Bekers, O., Sep, S. J. S., Schaper, N. C., van Dieijen-Visser, M. P. & Meex, S. J. R., Apr 2016, In : Heart. 102, 8, p. 610-616

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Diurnal Rhythm of Cardiac Troponin: Consequences for the Diagnosis of Acute Myocardial Infarction

Klinkenberg, L. J. J., Wildi, K., van der Linden, N., Kouw, I. W. K., Niens, M., Twerenbold, R., Gimenez, M. R., Puelacher, C., Neuhaus, J. D., Hillinger, P., Nestelberger, T., Boeddinghaus, J., Grimm, K., Sabti, Z., Bons, J. A. P., van Suijlen, J. D. E., Tan, F. E. S., ten Kate, J., Bekers, O., van Loon, L. & 3 others, Visser - van Dieijen, M., Mueller, C. & Meex, S. J. R., Dec 2016, In : Clinical Chemistry. 62, 12, p. 1602-1611

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Prognostic value of basal high-sensitive cardiac troponin levels on mortality in the general population A meta-analysis

van der Linden, N., Klinkenberg, L. J. J., Bekers, O., van Loon, L. J. C., van Dieijen-Visser, M. P., Zeegers, M. P. & Meex, S. J. R., Dec 2016, In : Medicine. 95, 52, e5703.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Strenuous exercise induces a hyperreactive rebalanced haemostatic state that is more pronounced in men

Huskens, D., Roest, M., Remijn, J. A., Konings, J., Kremers, R. M. W., Bloemen, S., Schurgers, E., Selmeczi, A., Kelchtermans, H., van Meel, R., Meex, S. J., Kleinegris, M-C., de Groot, P. G., Urbanus, R. T., Ninivaggi, M. & de Laat, B., Jun 2016, In : Thrombosis and Haemostasis. 115, 6, p. 1109-1119

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Strong diurnal rhythm of troponin T, but not troponin I, in a patient with renal dysfunction

van der Linden, N., Cornelis, T., Klinkenberg, L. J. J., Kimenai, D. M., Hilderink, J. M., Litjens, E. J. R., Kooman, J. P., Bekers, O., van Dieijen-Visser, M. P. & Meex, S. J. R., 15 Oct 2016, In : International Journal of Cardiology. 221, p. 287-288

Research output: Contribution to journalEditorialAcademicpeer-review

Vitamin D Status Does Not Affect Disability Progression of Patients with Multiple Sclerosis over Three Year Follow-Up

Muris, A-H., Smolders, J., Rolf, L., Klinkenberg, L. J. J., van der Linden, N., Meex, S., Damoiseaux, J. & Hupperts, R., 8 Jun 2016, In : PLOS ONE. 11, 6, e0156122.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)
2015

Calculating the probability of change between two consecutive laboratory test results

Hilderink, J. M., Koopmans, R., Rennenberg, R., van Dieijen-Visser, M. P. & Meex, S. J. R., 2015, In : BMJ (e). 351, h5552.

Research output: Contribution to journalArticleAcademicpeer-review

The effect of exercise training on the course of cardiac troponin T and I levels: three independent training studies

van der Linden, N., Klinkenberg, L. J., Leenders, M., Tieland, M., Verdijk, L., Niens, M., van Suijlen, J. D. E., de Groot, L. C., Bekers, O., van Loon, L. J., van Dieijen-Visser, M. P. & Meex, S. J. R., 16 Dec 2015, In : Scientific Reports. 5, 6 p., 18320.

Research output: Contribution to journalArticleAcademicpeer-review

2014

Cardiac troponin in ischemic cardiomyocytes: Intracellular decrease before onset of cell death

Streng, A. S., Jacobs, L. H. J., Schwenk, R. W., Cardinaels, E. P. M., Meex, S. J. R., Glatz, J. F. C., Wodzig, W. K. W. H. & van Dieijen-Visser, M. P., Jun 2014, In : Experimental and Molecular Pathology. 96, 3, p. 339-345

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Circulating Cardiac Troponin T Exhibits a Diurnal Rhythm

Klinkenberg, L. J. J., van Dijk, J. W., Tan, F. E. S., van Loon, L. J. C., van Dieijen-Visser, M. P. & Meex, S. J. R., 1 Jan 2014, In : Journal of the American College of Cardiology. 63, 17, p. 1788-1795

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Immature platelet fraction measured on the Sysmex XN hemocytometer predicts thrombopoietic recovery after autologous stem cell transplantation

van der Linden, N., Klinkenberg, L. J. J., Meex, S. J. R., Beckers, E. A. M., de Wit, N. C. J. & Prinzen, L., Aug 2014, In : European Journal of Haematology. 93, 2, p. 150-156

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Reversal of hypoxia in murine atherosclerosis prevents necrotic core expansion by enhancing efferocytosis

Marsch, E., Theelen, T. L., Demandt, J. A., Jeurissen, M., van Gink, M., Verjans, R., Janssen, A., Cleutjens, J. P., Meex, S. J., Donners, M. M., Haenen, G., Schalkwijk, C. G., Dubois, L. J., Lambin, P., Mallat, Z., Gijbels, M. J., Heemskerk, J. W., Fisher, E. A., Biessen, E. A., Janssen, B. J. & 2 others, Daemen, M. J. & Sluimer, J. C., 1 Jan 2014, In : Arteriosclerosis Thrombosis and Vascular Biology. 34, 12, p. 2545-2553

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)
2012

A comprehensive review of upper reference limits reported for (high-)sensitivity cardiac troponin assays: The challenges that lie ahead

Cardinaels, E. P., Mingels, A. M., Jacobs, L. H., Meex, S. J., Bekers, O. & van Dieijen-Visser, M. P., May 2012, In : Clinical Chemistry and Laboratory Medicine. 50, 5, p. 791-806 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Strong link between basal and exercise-induced cardiac troponin T levels: Do both reflect risk?

Klinkenberg, L. J., Res, P. T., van Loon, L. J. C., van Dieijen-Visser, M. P. & Meex, S. J. R., 28 Jun 2012, In : International Journal of Cardiology. 158, 1, p. 129-131 4 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

5 Citations (Scopus)

Troponin, the best there is!

van Dieijen-Visser, M. P., Mingels, A. M., Jacobs, L. H., Cardinaels, E. P., Wodzig, K. W. H., Bekers, O., Klinkenberg, L. J. & Meex, S. J. R., 1 Jan 2012, In : Nederlands tijdschrift voor klinische chemie en laboratoriumgeneeskunde. 37, p. 15-18

Research output: Contribution to journalArticleAcademic

2011

Huh-7 or HepG2 cells: which is the better model for studying human apolipoprotein-B100 assembly and secretion?

Meex, S. J. R., Andreo, U., Sparks, J. D. & Fisher, E. A., Jan 2011, In : Journal of Lipid Research. 52, 1, p. 152-158

Research output: Contribution to journalArticleAcademicpeer-review

2008

Novel insights in the pathophysiology of insulin resistance : a molecular genetic approach

Meex, S. J. R., 1 Jan 2008, Maastricht: Universiteit Maastricht. 147 p.

Research output: ThesisDoctoral ThesisInternal

Open Access
File
276 Downloads (Pure)

Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: Association study in 2000 Dutch Caucasians

Meex, S. J., van Vliet-Ostaptchouk, J. V., van der Kallen, C. J. H., van Greevenbroek, M. M. J., Schalkwijk, C. G., Feskens, E. J. M., Blaak, E. E., Wijmenga, C., Hofker, M. H., Stehouwer, C. D. & de Bruin, T. W., 1 Jan 2008, In : Molecular Genetics and Metabolism. 94, 3, p. 352-355

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)
2007

Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians

Meex, S. J., van Greevenbroek, M. M. J., Ayoubi, T. A., Vlietinck, R., van Vliet-Ostaptchouk, J. V., Hofker, M. H., Vermeulen, V. M., Schalkwijk, C. G., Feskens, E. J., Boer, J. M., Stehouwer, C. D., van der Kallen, C. J. H. & de Bruin, T. W., 1 Jan 2007, In : Journal of Clinical Endocrinology & Metabolism. 92, 7, p. 2720-2725

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)
2005

Up-regulation of CD36/FAT in preadipocytes in familial combined hyperlipidemia

Meex, S. J. R., van der Kallen, C. J. H., van Greevenbroek, M. M., Eurlings, P. M., El Hasnaoui, M. M., Evelo, C. T., Lindsey, P. J., Luiken, J. J. F. P., Glatz, J. F. & de Bruin, T. W., 1 Jan 2005, In : Faseb Journal. 19, 14, p. 2063-2065

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)