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Personal profile

Research interests

Extracellular vesicles (EVs) are considered major players in promoting macrophage (MO) and VSMC-mediated calcification in vitro and in vivo. EVs can be produced by living cells (micro- and matrix vesicles, exosomes) and dying cells (apoptotic bodies) and are present in calcified arteries of CKD patients. VSMC can generate EVs in vitro that differ in composition and calcifying properties depending on environmental factors such as Ca2+ and phosphate, and phenotype. VSMC normally produce EVs that contain inhibitors of calcification such as carboxylated-MGP and Fetuin-A. Elevated Ca2+ and phosphate, inflammatory cytokines and reactive oxygen species can cause phenotypic switching and a shift of production towards EVs lacking inhibitors and exposing pro-calcifying phosphatidylserine (PS) and annexin A5. Little is known about other lipid moieties of EVs and their role in VC, e.g. phosphorylcholine (PC) and malone dialdehyde (MDA) although both are implicated in atherosclerosis.  

Education/Academic qualification

KIIT UNIVERSITY

Award Date: 12 Oct 2016

External positions

PhD Student, Marie Curie Fellow, Karolinska Institutet, Stockholm

1 Jul 2017 → …

CEO, Co-Founder , InkRUDS Biotech Pvt. Ltd

1 Jan 2017 → …

Keywords

  • R Medicine (General)